What are the mechanisms behind scar-formation and degeneration in collagen-rich tissues?
Scar-formation and degeneration of the cornea in the eye and of muscle tendons often lead to deteriorated vision and decreased mobility, respectively. The purpose of this project is to unravel the pathophysiological mechanisms behind such processes.
The picture shows the similarity between cornea (A) and muscle tendons (B). Both are dependent on the parallel organization of collagen, and the collagen-producing cells (arrows) in between. Collagen degradation and fiber malalignment, as well as apoptosis, angiogenesis, and pain, characterize several pathological conditions of collagen-rich tissues, but the underlying mechanisms are poorly understood. We aim to define intra- and intercellular signaling pathways that regulate the functional states of the collagen-synthesizing cells in muscle tendons and the cornea. One of our hypotheses is that locally produced neuromodulators contribute to excessive scaring by inhibiting apoptosis. The goal is to identify key processes that can be targeted in future intervention techniques preventing or reversing scar-formation.
Title of Project
Mechanisms of scar-formation and degeneration in collagen-rich tissues
with focus on the corneal stroma and muscle tendons
07/01/2009 - 12/31/2018
Neurobiology, Anatomy, Biomaterials, Histology
Head of research
Patrik Danielson, Department of Integrative Medical Biology (IMB)