Biofysikalisk kemi med läkemedelsinriktning; Teori, 5.5 hp

Om kursen

The course covers the following areas: • Thermodynamics and chemical equilibrium, with a focus on pH, and the role of these for drug solubility in various media. • Liquids and solutions: diffusion, viscosity, electrolyte solutions and colligative properties. • Physical theories of mixtures and phase diagrams for two and three component systems. Gibbs phase rule. • Polymers and physical properties of proteins. General characteristics, stability, good and less good solvents. • Intermolecular interactions (electrostatic, induced, dispersion and hydrogen bonding) and hydrophobic effect with examples of protein-ligand interactions. • Reaction and transport kinetics (reaction rate, reaction order, diffusion, temperature dependence) with application to dissolution and diffusion through membranes. • Surface and Colloid Chemistry: colloid systems, wetting of surfaces, surface tension, surface activity, micelles, bilayers, colloidal forces and the DLVO theory.

Utbildningsnivå: Avancerad nivå

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2013-01-28