https://www.umu.se/MIMS kalenderevenemangen-usSun, 20 Sep 2026 23:57:31 +0200https://www.umu.se/en/events/ssibs-seminar-shohei-hori_12180846/Shohei Hori, Tokyo University in Japan, lectures within the Integrated Biomedical Sciences Seminars.Fri, 25 Sep 2026 13:00:00 +0200<h2><strong>13-14: Control of CD8 T cell responses and memory homeostasis by MHC class II molecules</strong></h2><p>Speaker: Ruka Setoguchi, Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo</p><p>Host: Ryo Morimoto, Department of Molecular Biology, MIMS</p><h2>About the lecture:</h2><p>The mechanisms that regulate CD8 T cell responses and maintain memory CD8 T cell homeostasis remain incompletely understood. Previous observations that adoptively transferred memory CD8 T cells persist poorly in MHC class II (MHCII)-deficient mice suggested that CD4 T cell help is required for their maintenance. Here, we demonstrate that chronic interferon-&gamma; (IFN-&gamma;) signaling, rather than CD4 T cell deficiency, is responsible for the attrition of memory CD8 T cells in MHCII-deficient environments. Neutralization of IFN-&gamma; restores memory CD8 T cell numbers in MHCII-deficient mice, whereas repeated IFN-&gamma; administration or transduction with a gain-of-function STAT1 mutant reduces their numbers in wild-type mice.</p><p>We further show that excessive IFN-&gamma; is produced predominantly by endogenous colonic CD8 T cells and promotes colonic inflammation in MHCII-deficient mice. Moreover, the combined absence of CD4 T cells and MHCII&ndash;LAG-3 interactions drives aberrant CD8 T cell activation and excessive IFN-&gamma; production, primarily in the colon. These findings indicate that the loss of MHCII-dependent regulation leads to dysregulated CD8 T cell responses in the colon and secondary depletion of memory CD8 T cells, thereby revealing an unappreciated mechanism controlling CD8 T cell responses and memory CD8 T cell homeostasis.</p><h2><strong>14-15: Control of regulatory T cell development and function by the transcription factor Foxp3</strong></h2><p>Speaker: Shohei Hori, Tokyo University, Japan</p><p>Host: Ryo Morimoto, Department of Molecular Biology, MIMS</p><h2>About the lecture:</h2><p>Regulatory T (Treg) cells are central guardians of immune tolerance and tissue homeostasis. This notion is firmly supported by the finding that defective Treg development and function, caused by mutations in the Foxp3 gene, lead to devastating autoimmune diseases in both mice and humans. However, the molecular mechanisms that establish the epigenetic, transcriptional, and functional identity of Treg cells remain incompletely understood. Although Foxp3 has long been regarded as the master transcription factor of Treg cells, earlier studies suggested that its role in shaping their heterogeneous epigenetic and transcriptional landscapes might be limited or indirect. Our recent findings challenge this view. Using complementary gain- and loss-of-function approaches, we demonstrate that Foxp3 plays a more fundamental and direct role than previously appreciated, integrating cell-intrinsic states and environmental contexts to drive epigenetic and transcriptional programs that define Treg cell identity and function. Acting as a master yet context-dependent regulator, Foxp3 cooperates with signal-dependent transcription factors, including BATF, to coordinate the epigenetic and transcriptional programs underlying Treg cell identity and function.</p><h2><strong>About IBSS</strong></h2><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major grooveSeminarhttps://www.umu.se/en/events/ssibs-seminar-shohei-hori_12180846/2026-09-25T13:00:00+02:002026-09-25T15:00:00+02:00https://www.umu.se/en/events/basic-course-em-september-2026_12179287/The course combines fundamental theory with hands-on demonstrations to provide a solid understanding of Electron Microscopy in the biological scienceMon, 28 Sep 2026 09:00:00 +0200<p>This course combines fundamental theory with hands-on demonstrations to provide a solid understanding of electron microscopy in biological science. The contents include principles of electron microscopy, specimen preparation, cryo-electron microscopy, correlative light-electron microscopy, and 3D EM methods. The course also covers an introduction to popular software used during EM work.</p><p>Registration deadline: <strong>19 September 2026</strong></p><p>More information and the registration link are on the <strong><a href="/link/323364d8a6674d759890987ec079a25d.aspx?epslanguage=en" target="_blank" rel="noopener">course homepage</a>.</strong></p><p>Organiser: <a href="/link/fb48be8ddb6347308d7622d64012b103.aspx"><strong>Ume&aring; Centre for Electron Microscopy (UCEM)</strong></a></p>Glasburen and UCEM, KBC and EM buildingsCoursehttps://www.umu.se/en/events/basic-course-em-september-2026_12179287/2026-09-28T09:00:00+02:002026-09-30T16:00:00+02:00https://www.umu.se/en/events/ucmr-seminar-simon-muriu_12192033/Within the UCMR Visiting Scientist Programme, Simon Muriu gives a lecture.Mon, 28 Sep 2026 15:00:00 +0200<h2>Challenges and opportunities in the management of emerging and re-merging vector-borne diseases in Kenya</h2><p>Speaker: Simon Muriu, Professor, Department of Biological Sciences, Pwani University, Kilifi, Kenya. Chairperson, Pan-African Mosquito Control Association (PAMCA) in Kenya</p><p>Host: Olivia Wesula Lwande, UCMR, Department of Clinical Microbiology</p><p><em>The seminar is open to everyone interested.</em></p><h2>About the seminar:</h2><p>Tropical environments provide ideal conditions for the development of disease vectors and transmission of associated vector-borne pathogens. In the sub-Saharan Africa, Kenya included, human and animal health is threatened by the emergence and re-emergence of vector-borne diseases in the recent past with devastating consequences to the regional economies and human-wellbeing.&nbsp; Several factors associated with the transmission ecology of these pathogens have greatly contributed to the increasing burden of these vector&ndash;borne diseases particularly the expansion behavior of human and animal populations, habitat degradation, changing land-use patterns, climate change, international travel and trade, urbanization, poverty and cultural practices.&nbsp; The challenges of managing emerging and re-emerging vector-borne infections in Kenya is further exacerbated by her geographical location, growing human population, porous borders and close livestock-wildlife-human interactions. Occurrence of invasive vector species in the country combined with adaptive behavioral patterns of the local vector populations threatens to circumvent efforts being employed against the emergence and re-emergence of vector-borne infections.&nbsp;&nbsp;</p><p>However, opportunities exist in deployment of One Health approach with primary focus on establishing active collaborations at the animal-human-ecosystem interface, for better prevention and control of emerging and re-emerging vector-borne diseases. The multi-sectoral and transdisciplinary collaborative efforts are instrumental in research infrastructural development and capacity building among local populations in various fields. Furthermore, such undertakings have resulted in development of novel strategies and technologies interspersed with indigenous knowledge inputs necessary for successful implementation of mitigating efforts against emerging and re-emerging vector-borne diseases.</p>Stora hörsalen KBC (Carl Kempe salen)Seminarhttps://www.umu.se/en/events/ucmr-seminar-simon-muriu_12192033/2026-09-28T15:00:00+02:002026-09-28T16:00:00+02:00https://www.umu.se/en/events/ibss-seminar-conceicao-bettencour_12180850/Conceição Bettencourt from the University College London, UK, lectures within the Integrated Biomedical Sciences Seminars.Fri, 02 Oct 2026 14:00:00 +0200<h2><strong>Could dysregulation of oligodendrocyte and myelin-related genes be an early sign of neurodegenerative diseases?</strong></h2><p>Speaker: Concei&ccedil;&atilde;o Bettencourt, University College London, UK&nbsp;&nbsp;&nbsp;&nbsp;</p><p>Host: Vivien Horv&aacute;th, WCMM</p><h2><strong>About the lecture:</strong></h2><p>Much research into the aetiology of neurodegenerative diseases has focused on neuronal dysfunction, while studies on the contribution of glial cells, particularly oligodendrocytes, which produce the myelin sheath insulating neuronal axons, are only starting to emerge. Altered DNA methylation, an epigenetic modification that regulates gene expression, is well documented in Alzheimer&rsquo;s disease, and other neurodegenerative diseases, as well as in ageing. Yet, investigations on the contributions of DNA methylation to dysregulation of specific brain cell types remain limited. In recent years, the Bettencourt lab has been investigating the role of DNA methylation on the dysregulation of oligodendrocyte and myelin-related genes across neurodegenerative diseases, and how these changes may impact gene expression. Our DNA methylomic studies cover a range of neurodegenerative diseases, including Alzheimer&rsquo;s disease, frontotemporal dementias, Parkinson&rsquo;s disease and multiples system atrophy. Our findings suggest that oligodendrocyte-associated DNA methylation changes occur early across neurodegenerative diseases.</p><p><strong>About IBSS:</strong></p><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ibss-seminar-conceicao-bettencour_12180850/2026-10-02T14:00:00+02:002026-10-02T15:00:00+02:00https://www.umu.se/en/events/medchem-seminar-soham-gupta_12183210/Title: TBATue, 06 Oct 2026 15:15:00 +0200<p>Speaker:&nbsp;</p><h3>Soham Gupta</h3><p>Department of Laboratory Medicine, KI</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-soham-gupta_12183210/2026-10-06T15:15:00+02:002026-10-06T16:00:00+02:00https://www.umu.se/en/events/ibbs-seminar-hjm-harmsen-_12180854/HJM Harmsen (Hermie) from the University of Groningen, Netherlands, lectures within the Integrated Biomedical Sciences Seminars.Fri, 09 Oct 2026 14:00:00 +0200<h2><strong>Structural variations in bacterial genomes determine carbohydrate metabolism and link to human genetics and health</strong></h2><p>Speaker: Hermie J.M. Harmsen, University Medical Center Groningen</p><p>Host: Chinmay Dwibedi, Department of Clinical microbiology, MIMS</p><p><em>The lecture is open to everyone interested.</em></p><h2><strong>About the lecture:</strong></h2><p>The human gut microbiome is increasingly being recognized to play an important role in maintaining health. The bacterial families Lachnospiraceae and Oscillospiraceae in particular, are often reduced in disease states but are relatively poorly represented in culture collections. Cultured representatives are required to investigate the physiology and host interactions of gut microbes.</p><p>After establishing a culturomics platform combining a single basal culture medium with MALDI-TOF MS, we built-up a strain bank of more than a thousand gut isolates from healthy and inflammatory bowel disease cohorts. This strain library was used to validate various bioinformatic studies, such as a meta-analysis of associations between human genetic variation and gut microbial structural variation in different population cohorts.</p><p>First, strikingly, the presence rate of a structural variation segment in Faecalibacterium strains that harbours an N-acetylgalactosamine (GalNAc) utilization gene cluster is higher in individuals who secrete the type A oligosaccharide antigen terminating in GalNAc, a feature that is jointly determined by human ABO and FUT2 genotypes. In vitro experiments with Faecalibacterium strains demonstrated that GalNAc can be used as the sole carbohydrate source for F. prausnitzii strains that carry the GalNAc-metabolizing pathway. The GalNAc utilization genes are also associated with the host's cardiometabolic health, particularly in individuals with mucosal A-antigen.</p><p>Furthermore, structural variation in Anaerostipes hadrus genomes were detected that are linked to the BMI of the individuals. Further validation with strains showed it was related to variation a inositol degradation pathway and propionate production. Additional research on fiber utilization from chicory root showed an enrichment of beneficial bacteria such as the butyrate producing A. hadrus. This shows the potential of such food interventions to improve gut health.</p><p>Structural variations in bacterial genomes indicate adaptations of bacteria to both host genetics as well as to the diet of the host and give input to personalized intervention and biotherapeutics for human health.</p><p><strong>About IBBS:</strong></p><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ibbs-seminar-hjm-harmsen-_12180854/2026-10-09T14:00:00+02:002026-10-09T15:00:00+02:00https://www.umu.se/en/events/ssibs-seminar---benjamin-nilsson-payant_12184937/Benjamin Nilsson-Payant, Karolinska Institute, lectures within the Integrated Biomedical Sciences Seminars.Thu, 15 Oct 2026 14:00:00 +0200<h2>Of mice (&hellip; and bank voles &hellip;) and men: dissecting hantavirus-host species interactions to understand viral replication dynamics and pathogenicity</h2><p>Spekare: Benjamin Nilsson-Payant, Karolinska Institute, Sweden&nbsp;&nbsp;&nbsp;</p><p>Host: Max Renner, Department of Chemistry, UCMR</p><h2>About the leccture:</h2><p>Hantaviruses are zoonotic segmented negative-sense RNA viruses that asymptomatically circulate in rodents, shrews and bats. While most hantaviruses do not infect or cause disease in humans, some can cause highly pathogenic respiratory and renal disease characterized by a so-called &lsquo;cytokine storm&rsquo; resulting in high mortality rates. The mechanisms underlying why some hantaviruses remain asymptomatic while others can cause severe disease are still unknown. Recently, the accumulation of defective viral genomes has been implicated in viral pathogenesis for other RNA viruses, including influenza A virus and respiratory syncytial virus.</p><p>In our lab, we are taking a systematic and comprehensive approach to compare and contrast the host response to a wide range of pathogenic and non-pathogenic Old World and New World hantaviruses in human and natural host species backgrounds using multi-OMICS methodologies. We can link the transcriptional host response to the full viral replication landscape of hantaviruses using a combination of short-read and long-read RNA sequencing methods and have identified several distinct defective viral genome populations that are correlated with the antiviral response. In order to understand the molecular details of viral replication and DVG production in the context of the host cell, we are investigating the replication environment and identifying protein interaction partners of the hantavirus polymerase. Our aim is to identify critical host factors for viral replication and host adaptation that can serve as potential antiviral drug targets.</p><p>Our data helps to shed new light on the intricate processes that govern virus-host interactions during hantavirus replication and might help explain the underlying mechanisms of disease. These insights will aid our quest to further understand viral pathogenesis and to develop novel treatment strategies.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ssibs-seminar---benjamin-nilsson-payant_12184937/2026-10-15T14:00:00+02:002026-10-15T15:00:00+02:00https://www.umu.se/en/events/medchem-seminar-clement-cabanetos_12182714/Title: TBATue, 20 Oct 2026 15:15:00 +0200<p>Speaker:&nbsp;</p><h3>Clement Cabanetos</h3><p>The MOLTECH-Anjou laboratory, CNRS, University of Angers, France</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-clement-cabanetos_12182714/2026-10-20T15:15:00+02:002026-10-20T16:00:00+02:00https://www.umu.se/en/events/ssibs-seminar-karin-forsberg-_12180856/Karin Forsberg Nilsson, Uppsala University, Sweden, lectures within the Integrated Biomedical Sciences Seminars.Fri, 23 Oct 2026 14:00:00 +0200<h2><strong>Leveraging non-coding mutations with evolutionary constraint to discover novel driver genes in solid tumors</strong></h2><p>Speaker: Karin Forsberg Nilsson, Uppsala University, Sweden&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p><p>Host: &nbsp;Silvia Remeseiro, WCMM</p><h2>About the lecture:</h2><p>Cancer genomics has been biased against non-coding mutations (98% of all mutations), and driver mutations outside exons remain underrepresented. We hypothesized that a position under evolutionary constraint in the genome could be used to identify functional cancer mutations. In our previous work, we have successfully detected functionally active non-coding constraint mutations (NCCMs) in glioblastoma. The Zoonomia Consortium has since published single base (phyloP) constraint scores from whole genome alignments of 240 mammals. Based on a comparison to previous large-scale genome annotations, and data sets such as ClinVar we provide proof-of-concept that evolutionary constrained positions are enriched for variants behind human disease, e.g. medulloblastoma.</p><p>Next, we examined if NCCMs and their associated enriched genes exert functional effects across multiple tumor types. To investigate this, we annotated evolutionary constraint and mapped to somatic single‑nucleotide variants (SNVs) and indels across &gt;2,500 tumors representing 19 tumor types in the ICGC‑PCAWG dataset. This identified 56 pan-cancer and 132 cancer-type-specific putative driver genes enriched for NCCMs. Notably, genes with a high NCCM load rarely harbor protein-coding mutations, suggesting that distinct selective pressures preserve protein integrity while altering expression regulation.</p><h2><strong>About IBBS:</strong></h2><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ssibs-seminar-karin-forsberg-_12180856/2026-10-23T14:00:00+02:002026-10-23T15:00:00+02:00https://www.umu.se/en/events/medchem-seminar-sara-palma-tortosa_12183211/Title: TBATue, 03 Nov 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3><strong>Sara Palma Tortosa</strong></h3><p>Lund University</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-sara-palma-tortosa_12183211/2026-11-03T15:15:00+01:002026-11-03T16:00:00+01:00https://www.umu.se/en/events/kbc-days-2026_12170283/Annual interdisciplinary conference fostering collaboration across departments and research centres at the Chemical Biological Centre (KBC).Tue, 10 Nov 2026 09:00:00 +0100<p>Welcome to <strong>KBC DAYS 2026</strong>, the annual interdisciplinary conference of the <strong>Chemical Biological Centre (KBC)</strong>, taking place on <strong>10-11 November 2026</strong> at KBC, Ume&aring; University.</p><p>This year's theme,<em> "Dynamic Worlds: Responses and Transformations from Molecules to Landscapes",</em> explores how systems at every level, from atoms and molecules to ecosystems and landscapes, respond to and are transformed by internal and external influences.</p><p>The conference brings together researchers, students, research infrastructures, research support services, and external partners from across the KBC environment and beyond. The programme includes keynote lectures, presentations from newly recruited faculty members, award and grant recipients, postdocs, PhD students, Forskaraspirant Programme students, and research infrastructures.</p><p>KBC DAYS offers an excellent opportunity to discover new research, explore infrastructure and support services, exchange ideas, and build interdisciplinary collaborations!</p><p><em>Participation is free of charge, but registration is required.</em><br />Registration deadline: <strong>27 October 2026</strong>.</p><p>Read more and register:<br /><strong><a href="/link/b48d44a3ea4547ea9c7a7bae651d2f97.aspx">https://www.umu.se/en/kbc-days-2026/</a>&nbsp;</strong></p><p>&nbsp;</p><p><strong>Contact:</strong> <a href="mailto:info.kbc@umu.se">info.kbc@umu.se</a></p><p><strong>M</strong><strong>ore information:</strong></p><p>Find out more about the <a href="/link/69e360b5484d4a789f2b785e0ddb09c2.aspx">Chemical Biological Centre</a> and <a href="/link/5ca72b356e434b259edad4384bc4563b.aspx">former KBC DAYS conferences</a></p><p>Organiser: Chemical Biological Centre (KBC)</p>Carl Kempe salen, KBC buildingConferencehttps://www.umu.se/en/events/kbc-days-2026_12170283/2026-11-10T09:00:00+01:002026-11-11T17:00:00+01:00https://www.umu.se/en/events/ssibs-seminar-mirjam-munch_12180857/Mirjam Münch, Psychiatric Hospital of the University of Basel, Switzerland, lectures within the Integrated Biomedical Sciences Seminars.Fri, 13 Nov 2026 14:00:00 +0100<h2><strong>What do we know about the effects of light on human health?</strong></h2><p>Speaker: Mirjam M&uuml;nch, Psychiatric Hospital of the University of Basel, Switzerland</p><p>Host: Katharina Wulff, Department of Molecular Biology</p><h2><strong>About the lecture:</strong></h2><p>There is growing evidence that light is essential for human health and well-being. Beyond vision, light influences a wide range of physiological and behavioural processes through non-visual pathways via the eye, including sleep&ndash;wake regulation, circadian rhythms, cognitive performance, mood, and metabolic function. However, many fundamental questions remain unanswered. We still do not know the optimal dose, timing, duration, or spectral composition of light exposure required to promote different health outcomes, nor do we fully understand the mechanisms linking acute and chronic light exposure to physical and mental health beyond circadian regulation.<br />A major challenge is to account for the substantial inter-individual variability in responses to light. Factors such as age, sex, chronotype, genetics, skin pigmentation, pre-existing health conditions, occupation, and geographical location all influence how individuals respond to light exposure.<br />This presentation will summarize some aspects of the current state of knowledge, highlight key research gaps, and provide examples of how emerging evidence is being translated into practical applications.</p><p><strong>About IBSS</strong></p><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ssibs-seminar-mirjam-munch_12180857/2026-11-13T14:00:00+01:002026-11-13T15:00:00+01:00https://www.umu.se/en/events/medchem-seminar-edith-houben_12182719/Title: TBATue, 17 Nov 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3>Edith Houben</h3><p>Vrije Universiteit Amsterdam, The Netherlands</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-edith-houben_12182719/2026-11-17T15:15:00+01:002026-11-17T16:00:00+01:00https://www.umu.se/en/events/ssibs-seminar-marco-marcia_12180861/Marco Marcia, Uppsala University, Sweden, lectures within the Integrated Biomedical Sciences Seminars.Fri, 20 Nov 2026 14:00:00 +0100<h2>Dissecting biological mechanisms and folding dynamics of medically-relevant large non-coding RNAs</h2><p>Host: Xisca, Department of Molecular Biology</p><h2><strong>About the lecture:</strong></h2><p>We are experiencing an &ldquo;RNA revolution&rdquo;. Genomes are pervasively transcribed into more non-coding RNAs (ncRNAs) than protein-coding RNAs. Moreover, new pharmacological opportunities are emerging to treat human diseases via modulation of ncRNA functions, either by targeting ncRNAs with small molecules or by using ncRNAs as drug vectors. But while we have a deep knowledge of protein structure, function, and dynamics and can accurately predict protein 3D structures from sequence using artificial intelligence, our mechanistic understanding of ncRNAs is still critically limited. My group contributes to fill this knowledge gap by applying RNA biochemistry, structural, cellular and molecular biology to the characterization of catalytic and regulatory bacterial and eukaryotic ncRNAs. In my talk, I will first show how we have elucidated the molecular mechanism of splicing through enzymatic, crystallographic and computational studies on a bacterial spliceosome ancestor, called the group II intron. I will then explain the implications of our group II intron work on understanding eukaryotic splicing and on developing gene-specific and RNA-directed drugs to treat cancer, congenital syndromes and infections. Finally, I will conclude by describing how our studies of splicing machineries enabled us to develop the experimental toolkit for pioneering the characterization of a newly-discovered class of regulatory ncRNAs, the so-called long non-coding RNAs. These latter molecules are key regulators of eukaryotic gene expression, and we have succeeded in dissecting the structure-functional complexity of prototypical lncRNAs through an interdisciplinary evolutionary, cellular, and structural approach, including by imaging them in 3D for the first time. In summary, our work connects the 3D structure and dynamics of large ncRNAs to their vital biological functions and opens still-unexplored research perspectives to understand ncRNA biology and to exploit the translational potential of ncRNAs in RNA-based therapies.</p><p><strong>About IBBS:</strong></p><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ssibs-seminar-marco-marcia_12180861/2026-11-20T14:00:00+01:002026-11-20T15:00:00+01:00https://www.umu.se/en/events/medchem-seminar-silja-wessler_12182734/Title: TBATue, 24 Nov 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3><strong>Silja Wessler</strong></h3><p>Department Biosciences and Medical Biology, Microbial Infection and Cancer, Paris-Lodron University Salzburg, Austria</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-silja-wessler_12182734/2026-11-24T15:15:00+01:002026-11-24T16:00:00+01:00https://www.umu.se/en/events/ssibs-seminar-shahriar-mobashery_12180862/Shahriar Mobashery, Notre Damme University, US, lectures within the Integrated Biomedical Sciences Seminars.Fri, 27 Nov 2026 14:00:00 +0100<h2><strong>Repair Mechanism of Damaged Cell Wall as Target in Antibacterial Strategies</strong></h2><p>Speaker: Shahriar Mobashery, Notre Damme University, US&nbsp;</p><p>Host: Felipe Cava, Department of Molecular Biology, MIMS</p><h2><strong>About the lecture:</strong></h2><p>Members of <em>Enterobacteriaceae</em> and <em>Pseudomonas</em> <em>aeruginosa</em> have the ability to sense damage inflicted to their cell wall. The process involves chemical signaling, which will be a subject of my presentation.</p><p>A primary mechanism for this sensing and signalling involves the events of cell-wall recycling. The cell wall is degraded for recycling and then the cell wall is synthesized de novo for the repair function. The recycling events get initiated by the functions of a family of 11 lytic transglycosylases in <em>P. aeruginosa</em>, which generate the signalling factors that influence transcriptional events in the cytoplasm. The mechanisms of these processes and those of the early cytoplasmic steps of recycling have been the subject of study&nbsp;in my lab, which I will disclose in my presentation.</p><h2>About IBSS:</h2><p>Integrated Biomedical Science Seminars is a broad, open seminar series within life science.</p>Major GrooveSeminarhttps://www.umu.se/en/events/ssibs-seminar-shahriar-mobashery_12180862/2026-11-27T14:00:00+01:002026-11-27T15:00:00+01:00https://www.umu.se/en/events/medchem-seminar-mikhail-kudryashev_12182744/Title: TBATue, 01 Dec 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3><strong>Mikhail Kudryashev</strong></h3><p>Max Delbr&uuml;ck Center, Berlin, Germany</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-mikhail-kudryashev_12182744/2026-12-01T15:15:00+01:002026-12-01T16:00:00+01:00https://www.umu.se/en/events/medchem-seminar-martin-cohn_12182754/Title: TBATue, 08 Dec 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3><strong>Martin Cohn</strong></h3><p>Department of Molecular Biology, Ume&aring; University</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-martin-cohn_12182754/2026-12-08T15:15:00+01:002026-12-08T16:00:00+01:00https://www.umu.se/en/events/medchem-seminar-yolanda-camara_12182762/Title: TBATue, 15 Dec 2026 15:15:00 +0100<p>Speaker:&nbsp;</p><h3><strong>Yolanda C&aacute;mara</strong></h3><p>Vall d&rsquo;Hebron Research Institute, Barcelona, Spain</p><p>Title:</p><h3><strong>TBA</strong></h3><p>&nbsp;</p><p>More information about the <strong>MedChem Seminar Series</strong> and the schedule is <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=en"><strong>here</strong></a>.&nbsp;&nbsp;</p>KB.E3.01 (Lilla hörsalen), KBCSeminarhttps://www.umu.se/en/events/medchem-seminar-yolanda-camara_12182762/2026-12-15T15:15:00+01:002026-12-15T16:00:00+01:00