Biophysical Chemistry with Applications in Pharmaceutical Chemistry
7.5 credits
About the course
The course is divided into two parts: Theory (5.5 credits) and lab (2 credits). The course covers the following areas: • Thermodynamics and chemical equilibrium, with a focus on pH, and the role of these for drug solubility in various media. • Liquids and solutions: diffusion, viscosity, electrolyte solutions and colligative properties. • Physical theories of mixtures and phase diagrams for two and three component systems. Gibbs phase rule. • Polymers and physical properties of proteins. General characteristics, stability, good and less good solvents. • Intermolecular interactions (electrostatic, induced, dispersion and hydrogen bonding) and hydrophobic effect with examples of protein-ligand interactions. • Reaction and transport kinetics (reaction rate, reaction order, diffusion, temperature dependence) with application to dissolution and diffusion through membranes. • Surface and Colloid Chemistry: colloid systems, wetting of surfaces, surface tension, surface activity, micelles, bilayers, colloidal forces and the DLVO theory.
The course will be given in english if foreign studens participate.
This course contains occasions that are included in a degree programme at Umeå university and applies only to those of you who are admitted to the programme. You will receive information about application times and what applies to you from your institution.
