N-Acylethanolamines (NAE) are a family of lipids found in the body. Our research concerns whether NAE turnover is dysfunctional in illness, and whether it can be targeted for drug development
N-Acylethanolamines (NAE) are a family of lipids in the body that can act as a defense mechanism to combat inflammation and other pathological events. My research seeks answers to two main questions: 1) is the "NAE defense" system substandard in chronic inflammatory disease states such that it contributes to disease development, and 2) can the effects of NAE molecules be optimally enhanced by blocking multiple pathways for their degradation. We are also interested in how the signalling mediated by NAEs and related lipids is involved in cancer development. The overall goal of the research is to identify novel targets for drug development.