Emma Persson

Contact

emma.e.persson@umu.se

Works at

Affiliated as other position at Department of Diagnostics and Intervention Section: Oncology

Målpunkt M31, Byggnad 6M, plan 3, Norrlands universitetssjukhus, Translationellt forskningscentrum (TRC) Umeå universitet, 901 85 Umeå

Senior researcher in the field of cancer, with research projects focusing on two cancer stages that are major clinical challenges; metastatic disease and acquired treatment resistance.
My group is primarily working on projects involving cancer types that form metastases in the skeleton (prostate/breast/lung cancer) and primary bone cancers (focus on osteosarcoma).
The projects are translational, including both preclinical model systems as well as analysis of cancer patient samples

Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo

The Prostate, John Wiley & Sons 2021, Vol. 81, (8) : 452-462

Hagberg Thulin, Malin; Määttä, Jorma; Linder, Anna; et al.

Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor

Frontiers in Immunology, Frontiers Media S.A. 2019, Vol. 10

Persson, Emma; Souza, Pedro P. C.; Floriano-Marcelino, Thais; et al.

Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor β (TGFβ) signaling

The Prostate, Vol. 78, (6) : 446-456

Karlsson, Terese; Sundar, Reshma; Widmark, Anders; et al.

Oncostatin M induces tumorigenic properties in non-transformed human prostate epithelial cells, in part through activation of signal transducer and activator of transcription 3 (STAT3)

Biochemical and Biophysical Research Communications - BBRC, Vol. 498, (4) : 769-774

Sterbova, Simona; Karlsson, Terese; Persson, Emma

Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation

PLOS ONE, Vol. 11, (11)

Karlsson, Terese; Lundholm, Marie; Widmark, Anders; et al.

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study

PLOS ONE, PLoS ONE 2014, Vol. 9, (7) : e103479-

Björklund, Emmelie; Blomqvist, Anders; Joel, Hedlin; et al.

The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells.

BMC Research Notes, BioMed Central 2014, Vol. 7 : 441-447

Cipriano, Mariateresa; Gouveia-Figueira, Sandra; Persson, Emma; et al.

Potential upstream regulators of cannabinoid receptor 1 signaling in prostate cancer: A Bayesian network analysis of data from a tissue microarray

The Prostate, Vol. 74, (11) : 1107-1117

Häggström, Jenny; Cipriano, Mariateresa; Plym Forshell, Linus; et al.

Cell-line-specific stimulation of tumor cell aggressiveness by wound healing factors - a central role for STAT3

BMC Cancer, Vol. 13 : 33-

Ekblad, Lars; Lindgren, Gustaf; Persson, Emma; et al.

Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling

The FASEB Journal, Vol. 27, (7) : 2687-2701

Strålberg, Fredrik; Henning, Petra; Gjertsson, Inger; et al.

Lack of CD47 leads to impaired bone cell differentiation and results in an osteopenic bone phenotype

Bone, Vol. 50, (Supplement 1) : S42-S43

Koskinen, Cecilia; Persson, Emma; Baldock, P.; et al.

Retinoids Stimulate Periosteal Bone Resorption by Enhancing the Protein RANKL: a Response Inhibited by Monomeric Glucocorticoid Receptor

Journal of Biological Chemistry, Vol. 286 : 31425-31436

Conaway, H. Herschel; Pirhayati, Amir; Persson, Emma; et al.

The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts

Journal of Cellular Biochemistry, Wiley 2011, Vol. 112, (12) : 3732-3741

Persson, Emma; Lerner, Ulf H

Targeting the endocannabinoid system for the treatment of cancer: a practical view

Current Topics in Medicinal Chemistry, Bentham Science Publishers 2010, Vol. 10, (8) : 814-827

Fowler, Christopher J; Gustafsson, Sofia B; Chung, Sui Chu; et al.

Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4

PLOS ONE, Public Library of Science 2010, Vol. 5, (8) : e12275-

Thors, Lina; Bergh, Anders; Persson, Emma; et al.

Retinoids inhibit differentiation of hematopoietic osteoclast progenitors

The FASEB Journal, Bethesda, Md.: Federation of American Societies for Experimental Biolog 2009, Vol. 23, (10) : 3526-3538

Conaway, H Herschel; Persson, Emma; Halén, Marie; et al.

Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases.

Bone, Vol. 43, (1) : 72-83

Brechter, Anna Bernhold; Persson, Emma; Lundgren, Inger; et al.

Skelettet vid hälsa och sjukdom

Tandläkartidningen, Vol. 100, (5) : 84-90

Lerner, Ulf H; Lundberg, Pernilla; Brechter, Anna; et al.

Kinins and Neuro-osteogenic Factors

Principles of Bone Biology 3rd Edition, Amsterdam: Elsevier 2008 : 1025-1057

Lerner, Ulf H; Persson, Emma; Lundberg, Pernilla

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro.

Br J Pharmacol, Vol. 150, (2) : 186-91

Vandevoorde, S; Jonsson, K-O; Labar, G; et al.

Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway

Journal of Biological Chemistry, Vol. 281, (5) : 2414-2429

Palmqvist, Py; Lundberg, Pernilla; Persson, Emma; et al.

The neuropeptide VIP potentiates IL-6 production induced by proinflammatory osteotropic cytokines in calvarial osteoblasts and the osteoblastic cell line MC3T3-E1.

Biochemical and Biophysical Research Communications - BBRC, Vol. 335, (3) : 705-711

Persson, Emma; Lerner, Ulf

Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts.

Bone, Vol. 37, (4) : 513-529

Persson, Emma; Voznesensky, OS; Huang, YF; et al.

Stimulation of resorption in cultured mouse calvarial bones by thiazolidinediones.

Endocrinology, Vol. 146, (10) : 4349-4361

Schwab, AM; Granholm, S; Persson, Emma; et al.

IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kB ligand, osteoprotegerin, and receptor activator of NF-kB in mouse calvariae

Journal of Immunology, Vol. 169, (6) : 3353-3362

Palmqvist, Py; Persson, Emma; Conaway, HH; et al.

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