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Umeå University
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Håkan Hedman

PhD

Adjunct Professor of Molecular Oncology

Director of Research Laboratory at the Department of Diagnostics and Intervention

Research qualifications: Docent

Contact

E-mail
hakan.hedman@umu.se
Phone
+46 90 785 28 81

Works at

Affiliation
Adjunct professor at Department of Diagnostics and Intervention Section: Oncology
Location
Målpunkt M31, Byggnad 6M, plan 3, Norrlands universitetssjukhus, Translationellt forskningscentrum (TRC) Umeå universitet, 901 85 Umeå
Ligand-specific regulation of transforming growth factor beta superfamily factors by leucine-rich repeats and immunoglobulin-like domains proteins
PLOS ONE, Public Library of Science (PLoS) 2023, Vol. 18, (8)
Abdullah Nasir, Ahmad; Herdenberg, Carl; Hedman, Håkan
Hypothesis: Do LRIG proteins regulate stem cell quiescence by promoting BMP signaling?
Stem Cell Reviews and Reports, Springer 2023, Vol. 19, (1) : 59-66
Herdenberg, Carl; Hedman, Håkan
Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines
Scientific Reports, Springer Nature 2023, Vol. 13
Rosenbaum, Adam; Dahlin, Anna M.; Andersson, Ulrika; et al.
Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma
Acta Oncologica, Taylor & Francis 2022, Vol. 61, (11) : 1425-1433
Lorenzzi Löfgren de Melo, Alexandra; Linder, Anna; Sundfeldt, Karin; et al.
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Abdullah Nasir, Ahmad; Herdenberg, Carl; Hedman, Håkan
LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance
Oncogene, Springer Nature 2021, Vol. 40 : 3707-3718
Billing, Ola; Holmgren, Ylva; Nosek, Daniel; et al.
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation
Development, The Dompany of Biologists 2021, Vol. 148, (16)
De Vincenti, Ana Paula; Alsina, Fernando C.; Ferrero Restelli, Facundo; et al.
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
Communications Biology, Springer Nature 2021, Vol. 4, (1)
Herdenberg, Carl; Mutie, Pascal; Billing, Ola; et al.
LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer
BMC Cancer, BioMed Central 2020, Vol. 20, (1)
Faraz, Mahmood; Tellström, Andreas; Edwinsdotter Ardnor, Christina; et al.
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder
Kidney International, ELSEVIER SCIENCE INC 2019, Vol. 95, (5) : 1138-1152
Roberts, Neil A.; Hilton, Emma N.; Lopes, Filipa M.; et al.
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: association with prognosis in relation to HPV‑DNA and p16INK4a status
Oncology Reports, Spandidos Publications 2019, Vol. 42, (1) : 142-150
Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.
A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (9) : 3421-3435
Faraz, Mahmood; Herdenberg, Carl; Holmlund, Camilla; et al.
LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease
Lung Cancer, Elsevier 2018, Vol. 125 : 174-184
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer
International journal of oncology, Vol. 52, (4) : 1189-1197
Lindquist, David; Alsina, Fernando C.; Herdenberg, Carl; et al.
Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
Oncogenesis, Nature Publishing Group 2018, Vol. 7
Mao, Feng; Holmlund, Camilla; Faraz, Mahmood; et al.
LRIG1 Was Down-Regulated in Medullary Thyroid Cancer but No Significant Effect of LRIG1 Was Found in RET2B Transgenic Mice and Human Differentiated Thyroid Cancer
Neuroendocrinology, S. Karger 2017, Vol. 105 : 152-152
Lindquist, David; Henriksson, Roger; Hedman, Håkan
Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
Biochimica et Biophysica Acta, Elsevier 2017, Vol. 1868, (1) : 109-116
Neirinckx, Virginie; Hedman, Håkan; Niclou, Simone P.
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
PLOS ONE, Vol. 12, (8)
Ranhem, Cecilia; Larsson, Gabriella Lillsunde; Hedman, Håkan; et al.
Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling
EMBO Reports, Vol. 17, (4) : 601-616
Cruz Alsina, Fernando; Javier Hita, Francisco; Aldana Fontanet, Paula; et al.
Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, Vol. 310, (11) : R1045-R1052
Hellström, Martin; Ericsson, Madelene; Johansson, Bengt; et al.
LRIG1 is a prognostic biomarker in non-small cell lung cancer
Acta Oncologica, Taylor & Francis 2015, Vol. 54, (8) : 1113-1119
Kvarnbrink, Samuel; Karlsson, Terese; Edlund, Karolina; et al.
LRIG protein expression and HPV prevalence in vulvar cancer patients in northern Sweden
International Journal of Gynecological Cancer, Vol. 25, (9) : 684-684
Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
Developmental Cell, Vol. 35, (5) : 537-552
van Erp, Susan; van den Heuvel, Dianne M. A.; Fujita, Yuki; et al.
LRIG and cancer prognosis
Acta Oncologica, Informa Healthcare 2014, Vol. 53, (9) : 1135-1142
Lindquist, David; Kvarnbrink, Samuel; Henriksson, Roger; et al.
Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer
British Journal of Cancer, Nature Publishing Group 2014, Vol. 110, (7) : 1793-1800
Lindquist, David; Näsman, A.; Tarján, M.; et al.
Loss of LRIG1 Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer
Cancer Research, Vol. 74, (11) : 2928-2935
Thompson, Patricia A.; Ljuslinder, Ingrid; Tsavachidis, Spyros; et al.
The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
Neuro-Oncology, Vol. 15, (9) : 1200-1211
Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.
Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer.
Cancer Research, Vol. 73, (8: suppl 1) : 5315-
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma
International Journal of Oncology, Spandidos Publications 2013, Vol. 42, (1) : 247-252
Muller, Susanne; Lindquist, David; Kanter, Lena; et al.
Local delivery of the soluble form of the tumor suppressor and stem cell regulator LRIG1 potently inhibits in vivo growth of glioblastomas with either wildtype or mutant EGFR expression
European Journal of Cancer, Elsevier 2013, Vol. 49, (Supplement 2) : S777-S777, Meeting Abstract: 3307
Niclou, S. P.; Johansson, M.; Tiemann, K.; et al.
Lrig2-deficient mice are protected against PDGFB-induced glioma
PLOS ONE, Vol. 8, (9) : e73635-
Rondahl, Veronica; Holmlund, Camilla; Karlsson, Terese; et al.
ELUCIDATING THE MECHANISM OF RECEPTOR TYROSINE KINASE INHIBITION BY SOLUBLE LRIG1 IN GLIOBLASTOMA
Neuro-Oncology, Oxford University Press 2013, Vol. 15, (Supplement: 3) : 28-29
Tiemann, Katja; Hedman, Håkan; Niclou, Simone P.
Synergistic killing of Glioblastoma Stem-like cells by Bortezomib and HDAC Inhibitors
Anticancer Research, International Institute of Anticancer Research 2012, Vol. 32, (7 ; Special Issue) : 2407-2413
Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
Synergistic Killing of Glioblastoma Stem-like Cells by Bortezomib and HADC Inhibitors.
Anticancer Research, Vol. 32, (7) : 2407-2413
Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69
Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Journal of Neuro-Oncology, Vol. 108, (3) : 435-441
Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.
The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 15-16
Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.
Expression of the human LRIG genes and proteins as prognostic markers in human cancer
International Journal of Molecular Medicine, Spandidos publications 2012, Vol. 30, (Suppl 1) : S42-S42
Lindquist, David; Henriksson, Roger; Hedman, Hakan
Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
BMC Research Notes, Vol. 5, (216) : 1-5
Thomasson, Marcus; Hedman, Håkan; Ljungberg, Börje; et al.
Endogenous Inhibitors of Tyrosine Kinase Receptors: a Therapeutic Role for Soluble LRIG1 in Malignant Glioma?
European Journal of Cancer, Elsevier 2012, Vol. 48 : S152-S152
Tiemann, K.; Bernard, A.; Fack, F.; et al.
Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity.
Acta Oncologica, Informa Healthcare 2012, Vol. 51, (1) : 69-76
Wu, Xuping; Hedman, Håkan; Bergqvist, Michael; et al.
LRIG1 and the liar paradox in prostate cancer: A study of the expression and clinical significance of LRIG1 in prostate cancer.
International Journal of Cancer, Wiley 2011, Vol. 128, (12) : 2843-2852
Thomasson, Marcus; Wang, Baofeng; Hammarsten, Peter; et al.
Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1
Experimental Cell Research, New York: Academic Press 2011, Vol. 317, (4) : 504-512
Yi, Wei; Holmlund, Camilla; Nilsson, Jonas; et al.
LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix
Acta Oncologica, Informa Healthcare 2010, Vol. 49, (6) : 812-815
Hedman, Håkan; Lindström, Annika K; Tot, Tibor; et al.
Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.
Neuropathology (Kyoto. 1993), Vol. 29, (3) : 242-247
Holmlund, Camilla; Haapasalo, Hannu; Yi, Wei; et al.
Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer
Breast Cancer Research, Vol. 11, (3) : 403-
Ljuslinder, Ingrid; Golovleva, Irina; Henriksson, Roger; et al.
Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age
Clinical Neuropathology, Vol. 28, (1) : 21-27
Yi, W; Haapasalo, H; Holmlund, Camilla; et al.
Redistribution of LRIG proteins in psoriasis
Journal of Investigative Dermatology, Vol. 128, (5) : 1192-1195
Karlsson, Terese; Mark, Elisabeth B; Henriksson, Roger; et al.
LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking
International Journal of Gynecological Cancer, Vol. 18, (2) : 312-317
Lindström, Annika; Ekman, K; Stendahl, Ulf; et al.
Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.
Anticancer Research, Vol. 28, (3A) : 1493-1498
Sjödin, Anna; Ljuslinder, Ingrid; Henriksson, Roger; et al.
View publications in DiVA

Research groups

Head of research
Håkan Hedman Lab
TRC Board
Translational Research Centre