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Umeå University
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Jonas Barandun

As a structural biologist, I am fascinated by how evolution has shaped important molecular mechanisms and how pathogens use these for infection. I am a SciLifeLab National Fellow.

Contact

E-mail
jonas.barandun@umu.se
Phone
+46 90 785 67 56

Works at

Affiliation
Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS) Section: Research groups
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå
Affiliation
Affiliated as other position at Department of Molecular Biology Section: Group Jonas Barandun
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

In my research group, we are using a combination of in vivo assays, biochemistry and cryo-electron microscopy to study macromolecular complexes of specialized pathogenic organisms. We would like to understand the molecular basis of essential pathways in pathogens and uncover unique structural determinants that could serve as novel targets for antibiotics.

Publications

Scientific publications

Read more about my reserach:

The Barandun lab

Barandun lab, MIMS

Barandun lab, Integrated Structural Biology (ISB)

 

 

A conserved ribosomal protein has entirely dissimilar structures in different organisms
Molecular biology and evolution, Oxford University Press 2024, Vol. 41, (1)
Schierholz, Léon; Brown, Charlotte R.; Helena-Bueno, Karla; et al.
Ultrastructural insights into the microsporidian infection apparatus reveal the kinetics and morphological transitions of polar tube and cargo during host cell invasion
PLoS biology, Public Library of Science (PLoS) 2024, Vol. 22, (2)
Sharma, Himanshu; Jespersen, Nathan; Ehrenbolger, Kai; et al.
Functional annotation of a divergent genome using sequence and structure-based similarity
BMC Genomics, BioMed Central (BMC) 2024, Vol. 25, (1)
Svedberg, Dennis; Winiger, Rahel R.; Berg, Alexandra; et al.
Deep mutational scan of a drug efflux pump reveals its structure–function landscape
Nature Chemical Biology, Nature Publishing Group 2023, Vol. 19 : 440-450
Meier, Gianmarco; Thavarasah, Sujani; Ehrenbolger, Kai; et al.
Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores
Nature Communications, Nature Publishing Group 2022, Vol. 13, (1)
Jespersen, Nathan; Ehrenbolger, Kai; Winiger, Rahel; et al.
Impact of genome reduction in microsporidia
Microsporidia: current advances in biology, Cham: Springer 2022 : 1-42
Jespersen, Nathan; Monrroy, Leonardo; Barandun, Jonas
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11
Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.
Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome
PLoS biology, Public Library of Science 2020, Vol. 18, (10)
Ehrenbolger, Kai; Jespersen, Nathan; Sharma, Himanshu; et al.
Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome
Nature Microbiology, Nature Publishing Group 2019, Vol. 4, (11) : 1798-1804
Barandun, Jonas; Hunziker, Mirjam; Vossbrinck, Charles R.; et al.
Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus
Sharma, Himanshu; Jespersen, Nathan; Ehrenbolger, Kai; et al.
View publications in DiVA

Research groups

Head of research
Jonas Barandun Lab