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Jyoti Mohan Gurung

I am a post-doctoral fellow in the group of Matthew S Francis. My research is focused on understanding the assembly mechanisms of the type III secretion system (T3SS).

Works at

Affiliation
Postdoctoral fellow at Department of Molecular Biology Section: PhD students, Research group Matthew Francis
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

I am a post-doctoral fellow in the group of Matthew S Francis at the Molecular Biology department. My research is focused on understanding the assembly mechanisms of the type III secretion system (T3SS), a molecular syringe that inject proteins into eukaryotic host cells. In addition, I also study how bacteria employ the T3SS to modulate host cell functions.

It all started when I was studying my Masters in Molecular Biology at Umeå University. During the programme, I undertook several degree projects; each involved the exploration of virulence mechanisms in different pathogenic bacteria. Interested by how certain bacteria evolves to become more successful pathogen, I chose to pursue my PhD on type III secretion system of Y. pseudotuberculosis, the ancestor of the notorious and much feared plague causing Y. pestis. My PhD study utilized a cross-disciplinary approach that combined bacterial genetics, carried out at Umeå University, with structural biology, carried out at University of Turku, Finland. The goal was to study the spatiotemporal assembly of the T3SS at a molecular resolution. The study explored the bacterial side of T3SS biogenesis and function.

In my current post-doctoral study, I have shifted perspective to investigate the effect of T3SS from a host’s viewpoint.  In specific, I aim to understand how the effector proteins delivered by the T3SS modulate host cell signalling, with a particular emphasis on autophagy pathway. The project is a collaborative effort with Dr. Aftab Nadeem in the Department of Molecular Biology at Umeå University. Our approach combines genetic engineering, cell biology and immunofluorescence microscopy to uncover the cellular secrets of autophagy.

Virulence, London: Taylor & Francis Group 2023, Vol. 14, (1)
Farag, Salah; Francis, Monika K.; Gurung, Jyoti M.; et al.
Scientific Reports, Springer Nature 2023, Vol. 13, (1)
Negeri, Abebe Aseffa; Mamo, Hassen; Kumar Gahlot, Dharmender; et al.
Molecular Microbiology, John Wiley & Sons 2022, Vol. 117, (4) : 886-906
Gurung, Jyoti; Amer, Ayad; Chen, Shiyun; et al.
Umeå: Umeå University 2020
Gurung, Jyoti Mohan
Virulence, Taylor & Francis Group 2019, Vol. 10, (1) : 37-57
Thanikkal, Edvin J.; Kumar Gahlot, Dharmender; Liu, Junfa; et al.
Frontiers in Cellular and Infection Microbiology, Frontiers Research Foundation 2018, Vol. 8
Gurung, Jyoti M.; Amer, Ayad; Francis, Monika; et al.
Frontiers in Cellular and Infection Microbiology, Vol. 6
Amer, Ayad; Gurung, Jyoti; Costa, Tiago; et al.
PLOS ONE, PLOS 2014, Vol. 9, (7)
Song, Tianyan; Sabharwal, Dharmesh; Gurung, Jyoti Mohan; et al.

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