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Mingde Wang
Research qualifications:
Docent
Contact
E-mail
mingde.wang@umu.se
Phone
+46 90 785 33 23
Works at
Affiliation
Affiliated as other position at
Department of Clinical Sciences
Section: Obstetrics and Gynecology
Location
by 5B, 5 tr, NUS
Umeå universitet, Kinisk vetenskap, Obstetrik och gynekologi, 90185 Umeå
Publications
Publications
2020
GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?
Neurobiology of stress
, Elsevier 2020, Vol. 12
Bengtsson, Sara; Bäckström, Torbjörn; Brinton, R.; et al.
2016
The author's reply: Blood allopregnanolone levels in women with polycystic ovary syndrome
Clinical Endocrinology
, Vol. 85, (1) : 152-154
Turkmen, Sahruh; Bixo, Marie; Hedström, Helena; et al.
2015
Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABA
A
receptor sensitivity to allopregnanolone
Clinical Endocrinology
, John Wiley & Sons 2015, Vol. 83, (5) : 643-650
Hedström, Helena; Bäckström, Torbjörn; Bixo, Marie; et al.
2013
Brief but Chronic Increase in Allopregnanolone Cause Accelerated ADPathology Differently in Two Mouse Models
Current Alzheimer Research
, Bentham Science Publishers 2013, Vol. 10, (1) : 38-47
Bengtsson, Sara; Johansson, Maja; Bäckström, Torbjörn; et al.
2013
Brief but Chronic Increase in Allopregnanolone Cause Accelerated AD Pathology Differently in Two Mouse Models
Current Alzheimer Research
, Bentham Science Publishers 2013, Vol. 10, (1) : 38-47
Bengtsson, Sara K.; Johansson, Maja; Bäckström, Torbjörn; et al.
2013
Neurosteroids and brain aging
Minerva Ginecologica
, Edizioni Minerva Medica 2013, Vol. 65, (6) : 587-605
Wang, Mingde
2012
Chronic Allopregnanolone Treatment Accelerates Alzheimer's Disease Development in A beta PP(Swe)PSEN1(Delta E9) Mice
Journal of Alzheimer's Disease
, Vol. 31, (1) : 71-84
Bengtsson, Sara K.; Johansson, Maja; Bäckström, Torbjörn; et al.
2011
Neurosteroids and GABA-A receptor function
Frontiers in Neuroendocrine science
, Vol. 2, (44) : 1-23
Wang, Mingde
2010
Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit
Clinical and experimental pharmacology & physiology
, Blackwell Publishing 2010, Vol. 37, (7) : 662-669
Wang, Ming-De; Rahman, Mozibur; Johansson, Inga-Maj; et al.
2009
The effect of the neuroactive steroid 5β-pregnane-3β, 20(R)-diol on the time course of GABA evoked currents is different to that of pregnenolone sulphate
European Journal of Pharmacology
, Vol. 605, (1-3) : 78-86
Strömberg, Jessica; Lundgren, Per; Taube, Magdalena; et al.
2008
A comparison of the pharmacological properties of recombinant human and rat α
1
β
2
γ
2L
GABA
A
receptors in Xenopus oocytes
Clinical and experimental pharmacology & physiology
, Vol. 35, (9) : 1002-1011
Rahman, Mozibur; Borra, Vijaya B; Isaksson, Monica; et al.
2008
Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA(A) receptor.
Eur J Pharmacol
, Vol. 586, (1-3) : 67-73
Wang, Ming-De; Borra, Vijaya Bhaskar; Strömberg, Jessica; et al.
2007
3Beta-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABA(A) receptor through different channel property.
European Journal of Pharmacology
, Vol. 557, (2-3) : 124-131
Wang, Ming-De; Rahman, Mozibur; Zhu, Di; et al.
2006
Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems.
Brain Research Reviews
, Vol. 51, (2) : 212-239
Birzniece, Vita; Bäckström, Torbjörn; Johansson, Inga-Maj; et al.
2006
GABA-site antagonism and pentobarbital actions do not depend on the α-subunit type in the recombinant rat GABA-A receptor
Acta Physiologica
, Vol. 187, (4) : 479-488
Mozibur, Rahman; Zhu, Di; Lindblad, Charlotte; et al.
2006
Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.
Eur J Pharmacol
, Vol. 547, (1-3) : 37-44
Rahman, Mozibur; Lindblad, Charlotte; Johansson, Inga-Maj; et al.
2006
Pregnenolone sulfate and zinc inhibit recombinant rat GABAA receptor through different channel property
Acta Physiologica
, Vol. 188, (3/4) : 153-163
Wang, Ming-De; Rahman, Mozibur; Zhu, Di; et al.
2005
Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats
European Journal of Pharmacology
, Amsterdam: North-Holland 2005, Vol. 512, (1) : 15-21
Bäckström, Torbjörn; Wahlström, Göran; Wahlström, Kerstin; et al.
2005
Protons inhibit Cl- conductance by direct or allosteric interaction with the GABA-binding site in the rat recombinant alpha(1)beta(2)gamma(2L) and alpha(1)beta(2) GABA(A) receptor
European Journal of Pharmacology
, Amsterdam: Elsevier 2005, Vol. 528, (1-3) : 1-6
Wang, Ming-De; Rahman, Mozibur; Zhu, Di
2004
Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors
Molecular Pharmacology
, Vol. 65, (5) : 1191-1197
Mennerick, Steven; He, Yejun; Jiang, Xin; et al.
2003
Pathogenesis in menstrual cycle-linked CNS disorders.
Annals of the New York Academy of Sciences
, Vol. 1007 : 42-53
Bäckström, Torbjörn; Andersson, Agneta; Andreén, Lotta; et al.
2003
The role of hormones and hormonal treatments in premenstrual syndrome
CNS Drugs
, Vol. 17, (5) : 325-342
Bäckström, Torbjörn; Andreen, Lotta; Birzniece, Vita; et al.
2003
Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnane-20-one (isoallopregnanolone)
Brain Research
, Vol. 982, (1) : 45-53
Lundgren, Per; Strömberg, Jessica; Bäckström, Torbjörn; et al.
2002
Ovarian hormone effects on 5-hydroxytryptamine (2A) and 5-hydroxytryptamine (2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats.
Neuroscience Letters
, Vol. 319, (3) : 157-161
Birzniece, Vita; Johansson, I-M; Wang, MD; et al.
2002
3beta-hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists
Journal of Neuroscience
, Vol. 22, (9) : 3366-3375
Wang, Mingde; He, Yejun; Eisenman, Lawrence N; et al.
2001
Serotonin 5-HT(1A) receptor mRNA expression in dorsal hippocampus and raphe nuclei after gonadal hormone manipulation in female rats.
Neuroendocrinology
, Vol. 74, (2) : 135-142
Birzniece, Vita; Johansson, I-M; Wang, MD; et al.
Chronic allopregnanolone elevation cause altered plaque production in Swe/PS1 mice
Bengtsson, Sara; Lundgren, Per; Gouissem, Samira; et al.
Does chronic endogenous exposure to neuroactive steroids change receptor sensitivity to allopregnanolone in humans?
Hedström, Helena; Bäckström, Torbjörn; Bixo, Marie; et al.
Allopregnanolone, a GABA-A receptor agonist, decreases gonadotropin levels in healthy fertile women but not in women with polycystic ovary syndrome
Hedström, Helena; Bäckström, Torbjörn; Wang, Mingde; et al.
Functional difference between recombinant human and rat α1β2γ2L GABAA receptors
Rahman, Mozibur; Isaksson, Monica; Johansson, Inga-Maj; et al.
The neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol alters the kinetic properties of the GABA-A receptor differently from pregnenolone-sulfate
Strömberg, Jessica; Lundgren, Per; Taube, Magdalena; et al.
S100A9-driven amyloid-neuroinflammatory cascade in traumatic brain injury as a risk factor for Alzheimer’s disease
Wang, Chao; Iashchishyn, Igor; Nyström, Sofie; et al.
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