Nelson Ongondo Gekara

Contact

nelson.gekara@umu.se

+46 90 785 08 17

Works at

Affiliated as other position at Department of Clinical Microbiology Units: Immunology

6, Universitetssjukhuset, Immunologi, plan 1 Umeå universitet, 901 85 Umeå

Publications Publications

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

Immunity, Cell Press 2022, Vol. 55, (5) : 847-861

Erttmann, Saskia F.; Swacha, Patrycja; Aung, Kyaw Min; et al.

Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity

Nature Communications, Nature Publishing Group 2019, Vol. 10

Erttmann, Saskia F.; Gekara, Nelson O.

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

Science Signaling, Washington: American Association for the Advancement of Science 2019, Vol. 12, (581)

Gekara, Nelson O.; Jiang, Hui

Comet and micronucleus assays for analyzing DNA damage and genome integrity

DNA SENSORS AND INFLAMMASOMES, ELSEVIER ACADEMIC PRESS INC 2019 : 299-307

Jiang, Hui; Panda, Swarupa; Gekara, Nelson O.

Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

EMBO Journal, EMBOpress 2019, Vol. 38, (21)

Jiang, Hui; Xue, Xiaoyu; Panda, Swarupa; et al.

TUBE and UbiCRest assays for elucidating polyubiquitin modifications in protein complexes

DNA SENSORS AND INFLAMMASOMES, ELSEVIER ACADEMIC PRESS INC 2019 : 339-350

Panda, Swarupa; Jiang, Hui; Gekara, Nelson O.

Biochemical and microscopic analysis of inflammasome complex formation

DNA Sensors and Inflammasomes, Elsevier 2019 : 287-298

Swacha, Patrycja; Gekara, Nelson O.; Erttmann, Saskia F.

DNA damage-induced immune response: Micronuclei provide key platform

Journal of Cell Biology, ROCKEFELLER UNIV PRESS 2017, Vol. 216, (10) : 2999-3001

Gekara, Nelson O.

Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes

Cellular Microbiology, Hoboken: Wiley-Blackwell 2017, Vol. 19, (11)

Putzova, Daniela; Panda, Swarupa; Härtlova, Anetta; et al.

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

PLoS Pathogens, Public Library Science 2017, Vol. 13, (6)

Webster, Steve J.; Brode, Sven; Ellis, Lou; et al.

Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity

Immunity, Vol. 45, (1) : 106-118

Erttmann, Saskia F.; Härtlova, Anetta; Sloniecka, Marta; et al.

Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1

Journal of Neuroinflammation, Vol. 13

Kurhade, Chaitanya; Zegenhagen, Loreen; Weber, Elvira; et al.

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

Journal of Neuroinflammation, Vol. 13

Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; et al.

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

Immunity, Vol. 42, (2) : 332-343

Härtlova, Anetta; Erttmann, Saskia F.; Raffi, Faizal A. M.; et al.

Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes

Immunity, Elsevier 2015, Vol. 43, (4) : 647-659

Panda, Swarupa; Nilsson, Jonas A.; Gekara, Nelson O.

Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism

PLOS ONE, Vol. 9, (1) : e87859-

Erttmann, Saskia F.; Gekara, Nelson O.; Fällman, Maria

Quantitative proteomics analysis of macrophage-derived lipid rafts reveals induction of autophagy pathway at the early time of Francisella tularensis LVS infection

Journal of Proteome Research, Vol. 13, (2) : 796-804

Härtlova, Anetta; Link, Marek; Balounova, Jana; et al.

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses

Journal of Virology, American Society for Microbiology 2014, Vol. 89, (21) : 12202-12212

Weber, Elvira; Finsterbusch, Katja; Lindquist, Richard; et al.

SIGN-R1+MHC II+ cells of the splenic marginal zone: a novel type of resident dendritic cells

Journal of Leukocyte Biology, Vol. 89, (4) : 607-615

Łyszkiewicz, Marcin; Zietara, Natalia; Rohde, Manfred; et al.

Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments.

PloS one, Vol. 5, (4) : e10250-

Dietrich, Nicole; Lienenklaus, Stefan; Weiss, Siegfried; et al.

Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, (19) : 8748-8753

Dietrich, Nicole; Rohde, Manfred; Geffers, Robert; et al.

Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O

Journal of Infectious Diseases, Oxford University Press 2010, Vol. 202, (11) : 1698-1707

Gekara, Nelson O.; Zietara, Natalia; Geffers, Robert; et al.

Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition.

Journal of Infectious Diseases, Vol. 199, (1) : 124-33

Gekara, Nelson O; Dietrich, Nicole; Lyszkiewicz, Marcin; et al.

Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha.

PloS one, Vol. 4, (8) : e6692-

Leschner, Sara; Westphal, Kathrin; Dietrich, Nicole; et al.

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo.

Journal of Immunology, Vol. 183, (5) : 3229-3236

Lienenklaus, Stefan; Cornitescu, Marius; Zietara, Natalia; et al.

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Journal of Immunology, Vol. 183, (2) : 1099-1109

Zietara, Natalia; Łyszkiewicz, Marcin; Gekara, Nelson; et al.

Listeria monocytogenes desensitizes immune cells to subsequent Ca2+ signaling via listeriolysin O-induced depletion of intracellular Ca2+ stores.

Infection and Immunity, Vol. 76, (2) : 857-862

Gekara, Nelson O; Groebe, Lothar; Viegas, Nuno; et al.

Mast cells initiate early anti-Listeria host defences.

Cellular Microbiology, Vol. 10, (1) : 225-236

Gekara, Nelson O; Weiss, Siegfried

Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O.

Biochemistry, Vol. 46, (14) : 4425-4437

Bavdek, Andrej; Gekara, Nelson O; Priselac, Dragan; et al.

The multiple mechanisms of Ca2+ signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes.

Cellular Microbiology, Vol. 9, (8) : 2008-2021

Gekara, Nelson O; Westphal, Kathrin; Ma, Bin; et al.

The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization.

Cellular Microbiology, Vol. 7, (9) : 1345-1356

Gekara, Nelson O; Jacobs, Thomas; Chakraborty, Trinad; et al.

Lipid rafts clustering and signalling by listeriolysin O.

Biochemical Society Transactions, Vol. 32, (Pt 5) : 712-714

Gekara, N O; Weiss, S

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