Pernilla Lundberg

DDS. PhD

Professor in Molecular Periodontology

Senior Consultant in Periodontology.

Contact

pernilla.lundberg@umu.se

+46 90 785 62 94

Works at

Professor, senior consultant dentist at Department of Odontology Section: School of Dentistry, Molecular Periodontology

1A, våning 6, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

LIGHT protein: a novel gingival crevicular fluid biomarker associated with increased probing depth after periodontal surgery

Journal of Clinical Periodontology

Esberg, Anders; Kindstedt, Elin; Isehed, Catrine; et al.

Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction

Journal of Clinical Medicine, MDPI 2022, Vol. 11, (4)

de Vries, Charlotte; Ruacho, Guillermo; Kindstedt, Elin; et al.

Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

Journal of Dental Research, Sage Publications 2022, Vol. 101, (11) : 1408-1416

Divaris, K.; Haworth, S.; Shaffer, J.R.; et al.

Oral characteristics in adult individuals with periodontal Ehlers-Danlos syndrome

Journal of Clinical Periodontology, John Wiley & Sons 2022, Vol. 49, (12) : 1244-1252

Lepperdinger, Ulrike; Angwin, Chloe; Milnes, Di; et al.

Enamel matrix derivative does not affect osteoclast formation or bone resorption in cultures of mouse bone marrow macrophages or human monocytes

Acta Odontologica Scandinavica, Taylor & Francis 2022, Vol. 80, (7) : 487-493

Lindquist, Susanne; Isehed, Catrine; Lie, Anita; et al.

Lack of CCR3 leads to a skeletal phenotype only in male mice

Biochemical and Biophysical Research Communications - BBRC, Vol. 620 : 98-104

Rosendahl, Sara; Sulniute, Rima; Persson, Julia; et al.

Serum proteins associated with periodontitis relapse post-surgery: A pilot study

Journal of Periodontology, John Wiley & Sons 2021, Vol. 92, (12) : 1805-1814

Esberg, Anders; Isehed, Catrine; Holmlund, Anders; et al.

Using national register data to estimate the heritability of periodontitis

Journal of Clinical Periodontology, John Wiley & Sons 2021, Vol. 48, (6) : 756-764

Haworth, Simon; Esberg, Anders; Kuja-Halkola, Ralf; et al.

CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2021, Vol. 296

Rosendahl, Sara; Sulniute, Rima; Eklund, Michaela; et al.

Peri-implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri-implantitis

Journal of Clinical Periodontology, John Wiley & Sons 2019, Vol. 46, (6) : 669-677

Esberg, Anders; Isehed, Catrine; Holmlund, Anders; et al.

Biological factors involved in alveolar bone regeneration Consensus report of Working Group 1 of the 15(th) European Workshop on Periodontology on Bone Regeneration

Journal of Clinical Periodontology, John Wiley & Sons 2019, Vol. 46 : 6-11

Giannobile, William V.; Berglundh, Tord; Al-Nawas, Bilal; et al.

Innate lymphoid cells are present in gingivitis and periodontitis

Journal of Periodontology, Wiley-Blackwell 2019, Vol. 90, (2) : 200-207

Kindstedt, Elin; Holm, Cecilia Koskinen; Palmqvist, Py; et al.

The critical interplay between bone resorbing and bone forming cells

Journal of Clinical Periodontology, John Wiley & Sons 2019, Vol. 46 : 33-51

Lerner, Ulf H.; Kindstedt, Elin; Lundberg, Pernilla

Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva

Scientific Reports, Nature Publishing Group 2019, Vol. 9

Souza, Pedro P. C.; Lundberg, Pernilla; Lundgren, Inger; et al.

Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3-and 5-year follow-up

Journal of Clinical Periodontology, John Wiley & Sons 2018, Vol. 45, (6) : 744-753

Isehed, Catrine; Svenson, Björn; Lundberg, Pernilla; et al.

Association between marginal jawbone loss and the onset of rheumatoid arhtritis and relationship to plasma levels of RANKL

Arthritis & Rheumatology, Wiley-Blackwell 2018, Vol. 70, (4) : 508-515

Kindstedt, Elin; Johansson, Linda; Palmqvist, Py; et al.

Periodontal manifestations of Ehlers-Danlos syndromes: a systematic review

Journal of Clinical Periodontology, John Wiley & Sons 2017, Vol. 44, (11) : 1088-1100

Kapferer-Seebacher, Ines; Lundberg, Pernilla; Malfait, Franziska; et al.

Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and Marginal Jawbone Loss Predates the Onset of Rheumatoid Arthritis

Arthritis & Rheumatology, Wiley-Blackwell 2017, Vol. 69

Kindstedt, Elin; Johansson, Linda; Palmqvist, Py; et al.

CCL11, a novel mediator of inflammatory bone resorption

Scientific Reports, Nature Publishing Group 2017, Vol. 7, (1)

Kindstedt, Elin; Koskinen Holm, Cecilia; Sulniute, Rima; et al.

Lack of SIRP alpha phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation

Biochemical and Biophysical Research Communications - BBRC, Vol. 478, (1) : 268-273

Holm, Cecilia Koskinen; Engman, Sara; Sulniute, Rima; et al.

Effectiveness of enamel matrix derivative on the clinical and microbiological outcomes following surgical regenerative treatment of peri-implantitis: A randomized controlled trial

Journal of Clinical Periodontology, John Wiley & Sons 2016, Vol. 43, (10) : 863-873

Isehed, Catrine; Holmlund, Anders; Renvert, Stefan; et al.

Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines

PLOS ONE, Vol. 10, (8)

Boström, Elisabeth A.; Kindstedt, Elin; Sulniute, Rima; et al.

Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappa B Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts

Journal of Biological Chemistry, Vol. 290, (33) : 20147-20158

Kassem, Ali; Henning, Petra; Lundberg, Pernilla; et al.

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen

PLoS One, plos one 2015, Vol. 10, (7)

Kolan, Shrikant; Lejon, Kristina; Koskinen Holm, Cecilia; et al.

Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

International Journal of Epidemiology, Vol. 44, (2) : 638-650

Shungin, Dmitry; Cornelis, Marilyn C.; Divaris, Kimon; et al.

The Newly Discovered Cytokine IL-34 Is Expressed in Gingival Fibroblasts, Shows Enhanced Expression by Pro-Inflammatory Cytokines, and Stimulates Osteoclast Differentiation

PLOS ONE, Public Library of Science 2013, Vol. 8, (12) : e81665-

Boström, Elisabeth A.; Lundberg, Pernilla

Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling

Journal of Biological Chemistry, Vol. 288, (41) : 29333-29344

Koskinen, Cecilia; Persson, Emelie; Baldock, Paul; et al.

IL-4 and IL-13 inhibit IL-1 beta and TNF-alpha induced kinin B-1 and B-2 receptors through a STAT6-dependent mechanism

British Journal of Pharmacology, Vol. 169, (2) : 400-412

Souza, P. P. C.; Brechter, A. B.; Reis, R. I.; et al.

Regulation of osteoclast formation by toll-like receptors 2 and 5

Bone, Vol. 50, (Supplement 1) : S67-S67

Kassem, Ali; Lunberg, Pernilla; Lindholm, C.; et al.

Regulation of osteoclast formation by toll-like receptors 2 and 5

Bone, Vol. 50, (Supplement 1) : S86-S87

Kassem, Ali; Lunberg, Pernilla; Lindholm, C.; et al.

Stimulation of bone resorption in calvarial bones by toll-like2 receptor through enhanced rankl

Annals of the Rheumatic Diseases, Vol. 71 : A68-A68

Kassem, Ali; Souza, Pedro C. C.; Lundberg, Pernilla; et al.

Lack of CD47 leads to impaired bone cell differentiation and results in an osteopenic bone phenotype

Bone, Vol. 50, (Supplement 1) : S42-S43

Koskinen, Cecilia; Persson, Emma; Baldock, P.; et al.

Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts

Molecular Immunology, Elsevier 2012, Vol. 49, (4) : 601-610

Souza, Pedro P. C.; Palmqvist, Py; Lundberg, Pernilla; et al.

Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2

Journal of Dental Research, Vol. 89, (8) : 802-807

Souza, PPC; Palmqvist, Py; Lundgren, Inger; et al.

Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation.

Journal of cellular biochemistry, Vol. 104, (3) : 920-933

Granholm, Susanne; Lundberg, Pernilla; Lerner, Ulf H

Skelettet vid hälsa och sjukdom

Tandläkartidningen, Vol. 100, (5) : 84-90

Lerner, Ulf H; Lundberg, Pernilla; Brechter, Anna; et al.

Kinins and Neuro-osteogenic Factors

Principles of Bone Biology 3rd Edition, Amsterdam: Elsevier 2008 : 1025-1057

Lerner, Ulf H; Persson, Emma; Lundberg, Pernilla

IL-1beta and TNF-alpha regulate IL-6-type cytokines in gingival fibroblasts.

Journal of Dental Research, Vol. 87, (6) : 558-563

Palmqvist, Py; Lundberg, Pernilla; Lundgren, Inger; et al.

Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients.

Arthritis Research & Therapy, Vol. 9, (1) : R18-

Andersson, MK; Lundberg, Pernilla; Ohlin, A; et al.

Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis.

Journal of Biological Chemistry, Vol. 282, (26) : 19092-19102

Baldock, PA; Allison, SJ; Lundberg, Pernilla; et al.

Calcitonin inhibits osteoclast formation in mouse haematopoetic cells independently of transcriptional regulation by receptor activator of NF-{kappa}B and c-Fms

The Journal of Endocrinology, Vol. 195, (3) : 415-427

Granholm, Susanne; Lundberg, Pernilla; Lerner, Ulf

Calcitonin inhibits osteoclast formation in mouse hematopoetic cells independently of transcriptional regulation by RANK and c-Fms

Journal of endocrinology, Vol. 195, (3) : 415-427

Granholm, Susanne; Lundberg, Pernilla; Lerner, Ulf H

Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression.

Journal of Biological Chemistry, Vol. 282, (26) : 19082-19091

Lundberg, Pernilla; Allison, SJ; Lee, NJ; et al.

Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction

Biochemical and Biophysical Research Communications - BBRC, Vol. 352, (2) : 444-448

Lundberg, Pernilla; Koskinen, Cecilia; Baldock, Paul A; et al.

Mutans streptococci colonization and longitudinal caries detection with laser fluorescence in fissures of newly erupted 1st permanent molars.

Acta Odontologica Scandinavica, Vol. 65, (4) : 189-193

Lundberg, Pernilla; Morhed-Hultvall, ML; Twetman, Svante

Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway

Journal of Biological Chemistry, Vol. 281, (5) : 2414-2429

Palmqvist, Py; Lundberg, Pernilla; Persson, Emma; et al.

Toll-like receptor induced inflammation causes local bone formation

ALi, Kassem; Henning, Petra; Lundberg, Pernilla; et al.

PICF proteome before and after adjunctive EMD treatment of peri-implantitis

Esberg, Anders; Isehed, Catrine; Holmlund, Anders; et al.

Discovery of Innate Lymphoid Cells in Gingivitis and Periodontitis

Kindstedt, Elin; Koskinen Holm, Cecilia; Palmqvist, Py; et al.

Reduced SIRPα phosphorylation and concommitant SHP-2–PI3K–Akt2 signaling decrease osteoblast differentiation

Koskinen, Cecilia; Engman, Sara; Sulniute, Rima; et al.

View publications in DiVA

Research projects

1 January 2020 until 1 January 2025

The tissue-destroying inflammation- Who is susceptible and how do we prevent or slow it down?

Published: 28 Jun, 2023

Odontological research is financed with TUA funds