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Jhon Alexander Rodriguez Buitrago

I am postdoc in Magnus Wolf-Watz group specializing in structural biology, with a focus on molecular mechanisms behind the aggressiveness and metastasis of prostate cancer. 

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Affiliation
Postdoctoral fellow at Department of Medical Biosciences
Location
By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå
Affiliation
Affiliated as postdoctoral position at Department of Chemistry
Location
KBC-huset (KB), Linnaeus väg 10 Umeå universitet, 901 87 Umeå

I am a highly skilled researcher specializing in structural biology, with a strong focus on elucidating the molecular mechanisms behind the aggressiveness and metastasis of prostate cancer and kidney cancer cells.

My work centers around unraveling how growth factors, specifically Transforming Growth Factor β (TGF-β), trigger these mechanisms in vitro models. My research leverages advanced techniques in structural biology, including X-ray crystallography, Cryo-Electron Microscopy (Cryo-EM), and Nuclear Magnetic Resonance (NMR) spectroscopy.I am adept at protein expression and purification, biophysical characterization, and protein-protein interaction analysis using Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), and thermofluor assays.

My research aims to contribute to the development of novel cancer therapies by deciphering the structural aspects of key proteins involved in cancer progression. Moreover, I am actively engaged in the search for predictive biomarkers, which could identify patients at risk of developing aggressive forms of cancer.

Currently, I am working as a postdoctoral researcher at Umea University in Magnus Wolf-Watz lab. My dedication to advancing structural biology techniques and their application to cancer research underscores my commitment to developing more effective and targeted cancer treatments, ultimately improving patient outcomes in the fight against cancer.

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