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Umeå University
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Ulf Lerner

Contact

E-mail
ulf.lerner@umu.se
Phone
+46 90 785 62 90

Works at

Affiliation
Affiliated as other position at Department of Odontology Section: School of Dentistry, Molecular Periodontology
Location
5A, våning 5, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå
The novel cytotoxic polybisphosphonate osteodex decreases bone resorption by enhancing cell death of mature osteoclasts without affecting osteoclastogenesis of RANKL-stimulated mouse bone marrow macrophages
Investigational new drugs
Henning, Petra; Westerlund, Anna; Movérare-Skrtic, Sofia; et al.
Mechanical load, sex hormones, and bone modeling
Biological Mechanisms of Tooth Movement, John Wiley & Sons 2021 : 100-116
Windahl, Sara H.; Lerner, Ulf H.
Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone–induced osteoclastogenesis
The FASEB Journal, Federation Amer Soc Exp Biol 2019, Vol. 33, (12) : 14394-14409
Conaway, H. Herschel; Henning, Petra; Lie, Antia; et al.
The critical interplay between bone resorbing and bone forming cells
Journal of Clinical Periodontology, John Wiley & Sons 2019, Vol. 46 : 33-51
Lerner, Ulf H.; Kindstedt, Elin; Lundberg, Pernilla
Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor
Frontiers in Immunology, Frontiers Media S.A. 2019, Vol. 10
Persson, Emma; Souza, Pedro P. C.; Floriano-Marcelino, Thais; et al.
Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Souza, Pedro P. C.; Lundberg, Pernilla; Lundgren, Inger; et al.
Bone remodeling in relation to androgen receptor activity in prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 50-50
Bovinder Ylitalo, Erik; Nordstrand, Annika; Thysell, Elin; et al.
Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (4)
Nordstrand, Annika; Bovinder Ylitalo, Erik; Thysell, Elin; et al.
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
Clinical and Experimental Metastasis, Springer 2017, Vol. 34, (3-4) : 261-271
Nordstrand, Annika; Halin Bergström, Sofia; Thysell, Elin; et al.
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Stattin, Eva-Lena; Henning, Petra; Klar, Joakim; et al.
Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors
Journal of Leukocyte Biology, FEDERATION AMER SOC EXP BIOL 2017, Vol. 101, (5) : 1233-1243
Strålberg, Fredrik; Kassem, Ali; Kasprzykowski, Franciszek; et al.
Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity
Bone, Vol. 93 : 43-54
Conaway, H. Herschel; Henning, Petra; Lie, Anita; et al.
Toll-Like Receptor 2 Stimulation of Osteoblasts Mediates Staphylococcus Aureus Induced Bone Resorption and Osteoclastogenesis through Enhanced RANKL
PLOS ONE, Vol. 11, (6)
Kassem, Ali; Lindholm, Catharina; Lerner, Ulf H.
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study
Journal of Internal Medicine, Vol. 280, (4) : 398-406
Lewerin, C.; Johansson, H.; Karlsson, M. K.; et al.
Osteoblast differentiation is enhanced by a nano-to-micro hybrid titanium surface created by Yb:YAG laser irradiation
Clinical Oral Investigations, Springer 2016, Vol. 20, (3) : 503-511
Mariscal-Munoz, Eduardo; Costa, Carlos A. S.; Tavares, Hewerson S.; et al.
Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines
PLOS ONE, Vol. 10, (8)
Boström, Elisabeth A.; Kindstedt, Elin; Sulniute, Rima; et al.
A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures
BoneKEy Reports, Vol. 4
Gori, Francesca; Lerner, Ulf; Ohlsson, Claes; et al.
Retinoid receptors in bone and their in bone remodeling
Frontiers in Endocrinology, Vol. 6
Henning, Petra; Conaway, H. Herschel; Lerner, Ulf H.
TLR5, a novel mediator of innate immunity-induced osteoclastogenesis and bone loss
The FASEB Journal, Vol. 29, (11) : 4449-4460
Kassem, Ali; Henning, Petra; Kindlund, Bert; et al.
Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappa B Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts
Journal of Biological Chemistry, Vol. 290, (33) : 20147-20158
Kassem, Ali; Henning, Petra; Lundberg, Pernilla; et al.
The WNT system: background and its role in bone
Journal of Internal Medicine, Wiley-Blackwell 2015, Vol. 277, (6) : 630-649
Lerner, Ulf H; Ohlsson, C
High serum adiponectin is associated with low blood haemoglobin in elderly men: the Swedish MrOS study
Journal of Internal Medicine, Vol. 278, (1) : 68-76
Lewerin, C.; Johansson, H.; Lerner, Ulf H.; et al.
Mechanical load, sex hormones, and bone modeling
Biological mechanisms of tooth movement, Wiley Blackwell 2015 : 82-96
Windahl, Sara H.; Lerner, Ulf H.
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden
Osteoporosis International, Springer London 2014, Vol. 25, (1) : 131-140
Lewerin, C.; Nilsson-Ehle, H.; Jacobsson, S.; et al.
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
Nature Medicine, Nature Publishing Group 2014, Vol. 20, (11) : 1279-1288
Movérare-Skrtic, Sofia; Henning, Petra; Liu, Xianwen; et al.
Vitamin A metabolism, action, and role in skeletal homeostasis
Endocrine reviews, The Endocrine Society 2013, Vol. 34, (6) : 766-797
Conaway, H. Herschel; Henning, Petra; Lerner, Ulf H.
Low-dose prednisolone in early rheumatoid arthritis inhibits collagen type I degradation by matrix metalloproteinases as assessed by serum 1CTP--a possible mechanism for specific inhibition of radiological destruction
Rheumatology, Vol. 52, (4) : 733-742
Engvall, Inga-Lill; Svensson, Björn; Boonen, Annelies; et al.
Osteoclast progenitor cells present in significant amounts in mouse calvarial osteoblast isolations and osteoclastogenesis increased by BMP-2
Bone, Vol. 52, (1) : 83-92
Granholm, Susanne; Henning, Petra; Lindholm, Catharina; et al.
Inhibition of the insulin-like growth factor-1 receptor enhances effects of Simvastatin on prostate cancer cells in co-culture with bone
Cancer Microenvironment, Springer 2013, Vol. 6, (3) : 231-240
Nordstrand, Annika; Lundholm, Marie; Larsson, Andreas; et al.
Activation of the liver X receptor-beta potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages
Journal of Leukocyte Biology, Vol. 93, (1) : 71-82
Remen, Kirsten M. Robertson; Lerner, Ulf H.; Gustafsson, Jan-Åke; et al.
Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrowderived macrophages
Journal of Leukocyte Biology, Vol. 93, (1) : 71-82
Robertson Remen, K. M.; Lerner, Ulf H.; Gustafsson, J.; et al.
IL-4 and IL-13 inhibit IL-1 beta and TNF-alpha induced kinin B-1 and B-2 receptors through a STAT6-dependent mechanism
British Journal of Pharmacology, Vol. 169, (2) : 400-412
Souza, P. P. C.; Brechter, A. B.; Reis, R. I.; et al.
The role of cytokines in inflammatory bone loss
Immunological Investigations, Vol. 42, (7) : 555-622
Souza, Pedro P. C.; Lerner, Ulf H.
Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling
The FASEB Journal, Vol. 27, (7) : 2687-2701
Strålberg, Fredrik; Henning, Petra; Gjertsson, Inger; et al.
Estrogen Receptor-alpha is required for the Osteogenic Response to mechanical loading in a Ligand-Independent manner involving its activation function 1 but Not 2
Journal of Bone and Mineral Research, Vol. 28, (2) : 291-301
Windahl, Sara H.; Saxon, Leanne; Borjesson, Anna E.; et al.
Inhibition of osteoclast formation in human peripheral CD14+cells by vitamin A
Bone, Vol. 50, (Supplement 1) : S92-S92
Henning, P.; Kindlund, B.; Pettersson, Ulrika; et al.
Interleukin 15 mediates joint destruction in staphylococcus aureus arthritis
Journal of Infectious Diseases, Vol. 206, (5) : 687-696
Henningsson, Louise; Jirholt, Pernilla; Bogestal, Yalda Rahpeymai; et al.
High serum adiponectin predicts incident fractures in elderly men: mr os sweden
Osteoporosis International, Vol. 23, (Suppl 2) : S306-S307
Johansson, H.; Oden, A.; Lerner, Ulf H.; et al.
High serum adiponectin predicts incident fractures in elderly men: osteoporotic fractures in men (MrOS) Sweden
Journal of Bone and Mineral Research, Vol. 27, (6) : 1390-1396
Johansson, Helena; Oden, Anders; Lerner, Ulf H; et al.
Regulation of osteoclast formation by toll-like receptors 2 and 5
Bone, Vol. 50, (Supplement 1) : S67-S67
Kassem, Ali; Lunberg, Pernilla; Lindholm, C.; et al.
Regulation of osteoclast formation by toll-like receptors 2 and 5
Bone, Vol. 50, (Supplement 1) : S86-S87
Kassem, Ali; Lunberg, Pernilla; Lindholm, C.; et al.
Stimulation of bone resorption in calvarial bones by toll-like2 receptor through enhanced rankl
Annals of the Rheumatic Diseases, Vol. 71 : A68-A68
Kassem, Ali; Souza, Pedro C. C.; Lundberg, Pernilla; et al.
Endokrin reglering av benförlust och benregeneration
BestPractice Reumatologi, (13) : 14-18
Lerner, Ulf
Skelettet i käkar och annorstädes: 4. Skelettet som ett hormonproducerande organ med betydelse för energimetabolism och fosfatutsöndring
Tandläkartidningen, Vol. 104, (8) : 60-68
Lerner, Ulf H
The biology of bone remodelling in jaw bones with and without teeth
Textbook of removable prosthodontics: the Scandinavian approach, Munksgaard Forlag 2012 : 51-60
Lerner, Ulf H
Osteoblasts, Osteoclasts, and Osteocytes: Unveiling Their Intimate-Associated Responses to Applied Orthodontic Forces
Seminars in orthodontics, Elsevier 2012, Vol. 18, (4) : 237-248
Lerner, Ulf H
Behandlingsprinciper för olika läkemedel vid osteoporos: skelettet i käkar och annorstädes, del 5
Tandläkartidningen, Vol. 104, (11) : 64-79
Lerner, Ulf H; Mellström, Dan
The gut microbiota regulates bone mass in mice
Journal of Bone and Mineral Research, Vol. 27, (6) : 1357-1367
Sjögren, Klara; Engdahl, Cecilia; Henning, Petra; et al.
Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts
Molecular Immunology, Elsevier 2012, Vol. 49, (4) : 601-610
Souza, Pedro P. C.; Palmqvist, Py; Lundberg, Pernilla; et al.
Cysteine proteinase inhibitors decrease rankl and lps induced differentiation of human and mouse osteoclast progenitor cells
Annals of the Rheumatic Diseases, Vol. 71 : A70-A70
Strålberg, Fredrik; Henning, P.; Gjertson, I; et al.
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