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Postdoctoral fellowship (2 years) in structural biology with focus on bacterial surface proteins and toxins

We now offer a postdoctoral fellowship within a project focusing on structural biology. Last day to apply is October 9, 2020.

Project description

The research issues in which the postdoctoral fellow will be engaged involve structure and function of bacterial proteins. The research is divided into two parts: 1) studies on surface proteins, adhesins and pili from both gram-positive and gram-negative bacteria, and 2) studies on a toxin that is secreted from a gram-negative pathogen. Selected protein will be studied from bacteria representing different phyla such as proteobacteriera, bacteroidetes och actinobacteria. In both projects structure biology methods have important roles, mainly X-ray crystallography and cryo-EM.  In relation to these projects we have previously solved crystal structures of both streptococcal adhesins as well as pili, and associated proteins from Actinomyces oris and Porphyromonas gingivalis. We have also solved structures of cytotoxins from Vibrio cholera. The present study will be performed using a blend of X-ray crystallography, cryo-EM, molecular biology, as well as biochemical and biophysical approaches.

The goal is to develop these projects further. For more details regarding the project topic, see:

https://www.biostruct.umu.se/principal-investigators/karina-persson/

The fellowship, financed by The Kempe Foundations, is for two years starting at the earliest possible time point as agreed. The stipend is 288 000 SEK per year tax-exempt.

Qualifications

The required qualification is a doctoral degree or a foreign degree that is deemed equivalent in structural biology, biochemistry or in an equivalent field, relevant for structural and functional characterization of proteins. Priority should be given to candidates who have completed their doctoral degree no more than three years before the closing date of the application. A candidate who has completed their degree prior to this may be considered if special circumstances exist. Special circumstances include absence due to illness, parental leave or clinical practice, appointments of trust in trade unions or similar circumstances.

The candidate must be able to carry out and plan scientific research independently but also in close collaboration with other members of the team, independence and good ability to collaborate is therefore a requirement. A good knowledge of English, both written and spoken is also a requirement. The candidate must also have knowledge in protein biochemistry and extensive laboratory experience of molecular and biochemical methods. Experience in cryo-electron microscopy is a strong merit.

Application

A complete application should include:

  1. a cover letter summarizing your qualifications, research interests and motivation for applying (maximum 2 pages),
  2. a Curriculum Vitae with a publication list,
  3. copies of doctoral degree certificate and other relevant degree certificates and grades,
  4. a copy of doctoral thesis,
  5. names and contact details of two reference persons,
  6. other relevant documents.

Submit your application as a PDF marked with the reference number FS 2.1.7-1660-20, both in the file name and in the subject field of the email, to medel@diarie.umu.se. The application can be written in English or Swedish. Application deadline is 9 October 2020.

Further information

For more information, please contact Associate professor Karina Persson (phone: +46-90-7865926, email: karina.persson@umu.se).