Institutionen för molekylärbiologi

Institutionen för molekylärbiologihttps://www.umu.se/A RSS feed provided by Umeå Universityen-usWed, 02 Sep 2026 09:42:21 +0200https://www.umu.se/kalender/ssibs-seminar-qiuwei-abdullah-pan_12180636/SSIBS seminar: Qiuwei Abdullah PanInom ramen för Integrated Biomedical Sciences Seminars föreläser Qiuwei Abdullah Pan, Erasmus MC-University Medical CentreFri, 04 Sep 2026 14:00:00 +0200<h2>Organoids as translational platforms for emerging viral diseases</h2>Talare: Qiuwei Abdullah Pan, Erasmus MC-University Medical Center, NetherlandsVärd: Aftab Nadeem, Department of Molecular Biology, UCMRFöreläsningen är på engelska<h2>Om föreläsningen:</h2>Emerging viral diseases pose major public health, economic and societal challenges. To advance our understanding of the pathophysiology and develop effective interventions, experimental models are required that closely mimic human biology. In particular, organoid platforms have begun to address key limitations of 2D cell line cultures and animal models in infectious disease research. In this talk, Dr. Pan will present the diverse applications of human organoids in investigating organ-specific infections and disease manifestations across major physiological systems, as well as the applications for antiviral drug discovery. This talk will focus on representative pathogens, including hepatitis E virus, monkeypox virus, Oropouche virus and measles virus. Finally, Dr. Pan will further discuss the innovation of immune-augmented organoids for modelling complex virus-host interactions, better understanding pathophysiology, and developing multi-target therapeutics.Major GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-qiuwei-abdullah-pan_12180636/2026-09-04T14:00:00+02:002026-09-04T15:00:00+02:00https://www.umu.se/kalender/publishing-workshop-for-junior-researchers-2026_12174474/Publishing Workshop for Junior Researchers 2026Workshop i livsvetenskapliga artiklar av AAAScience/SciLifeLab för doktorander och postdoktorer om publicering i ledande tidskrifter.Tue, 08 Sep 2026 08:30:00 +0200Utformat för doktorander och postdoktorer utforskar denna interaktiva workshop vetenskaplig publicering, peer review, AI i forskningskommunikation och strategier för publicering i ledande tidskrifter. Värd är SciLifeLab i samarbete med Science AAAS Magazine, och programmet kombinerar expertsessioner med praktiska diskussioner ledda av Science-redaktörer.<h3>Workshopledare</h3>Valda Vinson (Executive Editor, Science Magazine) och Sacha Vignieri (Deputy Editor, Research, Science Magazine) reser hela vägen från USA för att ge dig exklusiva insikter inifrån hela publiceringsprocessen – från att skriva och strukturera din artikel till peer review och påverkan efter publicering.<h3>Workshopprogram</h3>Vänligen besök den engelska sidan för mer information<h3>Praktisk information</h3>Workshopen är uppdelad i två sessioner: Morgonsession (hybrid) – En Zoom-länk kommer att skickas till online-deltagare en dag före workshopen. Eftermiddagssession (på plats) – Fokuserad på preprints inom livsvetenskapliga ämnen.<h3>Deltagarinformation</h3><ul><li>Doktorander och postdoktorer inom livsvetenskap prioriteras för den fysiska sessionen.</li><li>Förberedelser före workshopen krävs för alla deltagare på plats.</li><li>Alla är välkomna att delta online.</li></ul>Deltagande på plats inkluderar lunch och kaffepauser med Science-redaktörerna.<h2>Deltagande på plats är begränsat till 40 platser.</h2>Deltagare till den fysiska workshopen kommer att väljas efter sista ansökningsdag baserat på:<ul><li>Tillhörighet (för att säkerställa en rättvis fördelning mellan forskargrupper).</li><li>Först till kvarn-principen.</li></ul>Sista ansökningsdag för plats: 7 augusti Sista anmälningsdag för online-registrering: 3 septemberKBF301Workshophttps://www.umu.se/kalender/publishing-workshop-for-junior-researchers-2026_12174474/2026-09-08T08:30:00+02:002026-09-08T16:00:00+02:00https://www.umu.se/kalender/medkem-seminarserie-hanna-wacklin-knecht_12182712/Medkem seminarserie - Hanna Wacklin-KnechtTitel: ”Neutron scattering facilities at ESS for biomedical science and recent applications in cell membrane research”Tue, 08 Sep 2026 15:15:00 +0200* Seminarium kommer att vara på engelska.Talare:<h3>Hanna Wacklin-Knecht</h3>Head of Scientific Support Division, European Spallation Source ERIC, LundTitel:<h3>Neutron scattering facilities at ESS for biomedical science and recent applications in cell membrane research</h3> Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-hanna-wacklin-knecht_12182712/2026-09-08T15:15:00+02:002026-09-08T16:00:00+02:00https://www.umu.se/kalender/ssibs-seminar-bo-dong_12180842/SSIBS seminar: Bo DongInom ramen för Integrated Biomedical Sciences Seminars föreläser Bo Dong, Ocean University of China.Fri, 18 Sep 2026 14:00:00 +0200<h2>Identification of endogenous TH synthesis precursor and environmentally chemical attractant molecule for marine ascidian larvae settlement and metamorphosis</h2>Talare: Bo Dong, Ocean University of China, ChinaVärd: Sun Nyunt Wai, Institutionen för molekylärbiologi, UCMRFöreläsningen är på engelska<h2>Om föreläsningen:</h2>Marine ascidians belong to the tunicates and sit at a key evolutionary node between invertebrates and vertebrates, making them as living fossils for studying evolutionary developmental biology. The tadpole larvae of ascidian show distinct vertebrate-like morphological features, however, they lose important vertebrate organs like the brain, CNS, and notochord after metamorphosis. In this talk, I will introduce our recent findings on identification of the protein precursor for thyroid hormone synthesis in ascidian. This protein is a first-identified TH precursor outside vertebrates, playing essential roles on larvae metamorphosis. Except this endogenous regulatory molecule, we also identified an external environmental factor that trigger marine ascidian larvae settlement and metamorphogesis. I will discuss the implications of our studies in the emerging field of marine Eco-Evo-Devo research by establishing a model system for understanding developmental mechanisms in the context of marine ecosystems and aquaculture. Of interest is the potential development of antifouling strategies by targeting specific chemosensation.Major GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-bo-dong_12180842/2026-09-18T14:00:00+02:002026-09-18T15:00:00+02:00https://www.umu.se/kalender/ssibs-seminar-shohei-hori_12180846/SSIBS seminar: Shohei HoriInom ramen för Integrated Biomedical Sciences Seminars föreläser Shohei Hori, Tokyo University, japan.Fri, 25 Sep 2026 14:00:00 +0200<h2>Control of regulatory T cell development and function by the transcription factor Foxp3</h2>Talare: Shohei Hori, Tokyo University, JapanVärd: Ryo Morimoto, Institutionen för molekylärbiologi, MIMSFöreläsningen är på engelska<h2>Om föreläsningen:</h2>Regulatory T (Treg) cells are central guardians of immune tolerance and tissue homeostasis. This notion is firmly supported by the finding that defective Treg development and function, caused by mutations in the Foxp3 gene, lead to devastating autoimmune diseases in both mice and humans. However, the molecular mechanisms that establish the epigenetic, transcriptional, and functional identity of Treg cells remain incompletely understood. Although Foxp3 has long been regarded as the master transcription factor of Treg cells, earlier studies suggested that its role in shaping their heterogeneous epigenetic and transcriptional landscapes might be limited or indirect. Our recent findings challenge this view. Using complementary gain- and loss-of-function approaches, we demonstrate that Foxp3 plays a more fundamental and direct role than previously appreciated, integrating cell-intrinsic states and environmental contexts to drive epigenetic and transcriptional programs that define Treg cell identity and function. Acting as a master yet context-dependent regulator, Foxp3 cooperates with signal-dependent transcription factors, including BATF, to coordinate the epigenetic and transcriptional programs underlying Treg cell identity and function.About IBSSIntegrated Biomedical Science Seminars is a broad, open seminar series within life science.Major grooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-shohei-hori_12180846/2026-09-25T14:00:00+02:002026-09-25T15:00:00+02:00https://www.umu.se/kalender/ibss-seminar-conceicao-bettencour_12180850/SSIBS seminar Conceicao BettencourtInom ramen för Integrated Biomedical Sciences Seminars föreläser Conceicao Bettencourt from the University College London, UK.Fri, 02 Oct 2026 14:00:00 +0200<h2>Could dysregulation of oligodendrocyte and myelin-related genes be an early sign of neurodegenerative diseases?</h2>Föreläsare: Conceicao Bettencourt, University College London, UK    Värd: Vivien Horváth, WCMMFöreläsningen är på engelska<h2>Om föreläsningen:</h2>Much research into the aetiology of neurodegenerative diseases has focused on neuronal dysfunction, while studies on the contribution of glial cells, particularly oligodendrocytes, which produce the myelin sheath insulating neuronal axons, are only starting to emerge. Altered DNA methylation, an epigenetic modification that regulates gene expression, is well documented in Alzheimer’s disease, and other neurodegenerative diseases, as well as in ageing. Yet, investigations on the contributions of DNA methylation to dysregulation of specific brain cell types remain limited. In recent years, the Bettencourt lab has been investigating the role of DNA methylation on the dysregulation of oligodendrocyte and myelin-related genes across neurodegenerative diseases, and how these changes may impact gene expression. Our DNA methylomic studies cover a range of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementias, Parkinson’s disease and multiples system atrophy. Our findings suggest that oligodendrocyte-associated DNA methylation changes occur early across neurodegenerative diseases.Major GrooveSeminariumhttps://www.umu.se/kalender/ibss-seminar-conceicao-bettencour_12180850/2026-10-02T14:00:00+02:002026-10-02T15:00:00+02:00https://www.umu.se/kalender/medkem-seminarserie-soham-gupta_12183210/Medkem seminarserie - Soham GuptaTitel meddelas senareTue, 06 Oct 2026 15:15:00 +0200* Seminarium kommer att vara på engelska.Talare:<h3>Soham Gupta</h3>Institutionen för laboratoriemedicin, KI Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-soham-gupta_12183210/2026-10-06T15:15:00+02:002026-10-06T16:00:00+02:00https://www.umu.se/kalender/ibbs-seminar-hjm-harmsen-_12180854/SSIBS seminar: HJM HarmsenInom ramen för Integrated Biomedical Sciences Seminars föreläser HJM Harmsen (Hermie) from the University of Groningen, Netherlands.Fri, 09 Oct 2026 14:00:00 +0200Title: TBAHost: Chinmay Dwibedi, Department of Clinical Microbiologi, MIMSMajor GrooveSeminariumhttps://www.umu.se/kalender/ibbs-seminar-hjm-harmsen-_12180854/2026-10-09T14:00:00+02:002026-10-09T15:00:00+02:00https://www.umu.se/kalender/medkem-seminarserie-clement-cabanetos_12182714/Medkem seminarserie - Clement CabanetosTitel meddelas senareTue, 20 Oct 2026 15:15:00 +0200* Seminarium kommer att vara på engelska.Talare:<h3>Clement Cabanetos</h3>The MOLTECH-Anjou laboratory, CNRS, University of Angers, France Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-clement-cabanetos_12182714/2026-10-20T15:15:00+02:002026-10-20T16:00:00+02:00https://www.umu.se/kalender/ssibs-seminar-karin-forsberg-_12180856/SSIBS seminar: Karin Forsberg NilssonInom ramen för Integrated Biomedical Sciences Seminars föreläser Karin Forsberg Nilsson från Uppsala universitet.Fri, 23 Oct 2026 14:00:00 +0200<h2>Leveraging non-coding mutations with evolutionary constraint to discover novel driver genes in solid tumors</h2>Föreläsare: Karin Forsberg Nilsson, Uppsala universitetVärd: Silvia Remeseiro, WCMMFöreläsningen är på engelska<h2>Om föreläsningen:</h2>TBAMajor GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-karin-forsberg-_12180856/2026-10-23T14:00:00+02:002026-10-23T15:00:00+02:00https://www.umu.se/kalender/medkem-seminarserie-sara-palma-tortosa_12183211/Medkem seminarserie - Sara Palma TortosaTitel meddelas senareTue, 03 Nov 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Sara Palma Tortosa</h3>Lunds universitet Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-sara-palma-tortosa_12183211/2026-11-03T15:15:00+01:002026-11-03T16:00:00+01:00https://www.umu.se/kalender/kbc-days-2026_12170283/KBC DAYS 2026Årlig tvärvetenskaplig konferens som främjar samarbete mellan institutioner och forskningscentra vid Kemiskt Biologiskt Centrum (KBC).Tue, 10 Nov 2026 09:00:00 +0100Mer information på den engelska sidan.KBC DAYS 2026 med det vetenskapliga huvudtemat "Dynamic Worlds: Responses and Transformations from Molecules to Landscapes" äger rum den 10-11 november 2026 - spara datumet!Carl Kempe salen, KBC HusetKonferenshttps://www.umu.se/kalender/kbc-days-2026_12170283/2026-11-10T09:00:00+01:002026-11-11T17:00:00+01:00https://www.umu.se/kalender/ssibs-seminar-mirjam-munch_12180857/SSIBS seminar: Mirjam MünchInom ramen för Integrated Biomedical Sciences Seminars föreläser Mirjam Münch, Psychiatric Hospital of the University of Basel, Switzerland.Fri, 13 Nov 2026 14:00:00 +0100<h2>What do we know about the effects of light on human health?</h2>Föreläsare: Mirjam Münch, Psychiatric Hospital of the University of Basel, SwitzerlandVärd: Katharina Wulff, Institutionen för molekylärbiologiFöreläsningen är på engelska<h2>Om föreläsningen:</h2>There is growing evidence that light is essential for human health and well-being. Beyond vision, light influences a wide range of physiological and behavioural processes through non-visual pathways via the eye, including sleep–wake regulation, circadian rhythms, cognitive performance, mood, and metabolic function. However, many fundamental questions remain unanswered. We still do not know the optimal dose, timing, duration, or spectral composition of light exposure required to promote different health outcomes, nor do we fully understand the mechanisms linking acute and chronic light exposure to physical and mental health beyond circadian regulation. A major challenge is to account for the substantial inter-individual variability in responses to light. Factors such as age, sex, chronotype, genetics, skin pigmentation, pre-existing health conditions, occupation, and geographical location all influence how individuals respond to light exposure. This presentation will summarize some aspects of the current state of knowledge, highlight key research gaps, and provide examples of how emerging evidence is being translated into practical applications.Major GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-mirjam-munch_12180857/2026-11-13T14:00:00+01:002026-11-13T15:00:00+01:00https://www.umu.se/kalender/medkem-seminarserie-edith-houben_12182719/Medkem seminarserie - Edith HoubenTitel meddelas senareTue, 17 Nov 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Edith Houben</h3>Vrije Universiteit Amsterdam, The Netherlands Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-edith-houben_12182719/2026-11-17T15:15:00+01:002026-11-17T16:00:00+01:00https://www.umu.se/kalender/ssibs-seminar-marco-marcia_12180861/SSIBS seminar: Marco MarciaInom ramen för Integrated Biomedical Sciences Seminars föreläser Marco Marica från Uppsala universitet i Sverige.Fri, 20 Nov 2026 14:00:00 +0100<h2>Dissecting biological mechanisms and folding dynamics of medically-relevant large non-coding RNAs</h2>Värd: Xisca, Institutionen för molekylärbiologiFöredraget är på engelska.<h2>Om föreläsningen:</h2>We are experiencing an “RNA revolution”. Genomes are pervasively transcribed into more non-coding RNAs (ncRNAs) than protein-coding RNAs. Moreover, new pharmacological opportunities are emerging to treat human diseases via modulation of ncRNA functions, either by targeting ncRNAs with small molecules or by using ncRNAs as drug vectors. But while we have a deep knowledge of protein structure, function, and dynamics and can accurately predict protein 3D structures from sequence using artificial intelligence, our mechanistic understanding of ncRNAs is still critically limited. My group contributes to fill this knowledge gap by applying RNA biochemistry, structural, cellular and molecular biology to the characterization of catalytic and regulatory bacterial and eukaryotic ncRNAs. In my talk, I will first show how we have elucidated the molecular mechanism of splicing through enzymatic, crystallographic and computational studies on a bacterial spliceosome ancestor, called the group II intron. I will then explain the implications of our group II intron work on understanding eukaryotic splicing and on developing gene-specific and RNA-directed drugs to treat cancer, congenital syndromes and infections. Finally, I will conclude by describing how our studies of splicing machineries enabled us to develop the experimental toolkit for pioneering the characterization of a newly-discovered class of regulatory ncRNAs, the so-called long non-coding RNAs. These latter molecules are key regulators of eukaryotic gene expression, and we have succeeded in dissecting the structure-functional complexity of prototypical lncRNAs through an interdisciplinary evolutionary, cellular, and structural approach, including by imaging them in 3D for the first time. In summary, our work connects the 3D structure and dynamics of large ncRNAs to their vital biological functions and opens still-unexplored research perspectives to understand ncRNA biology and to exploit the translational potential of ncRNAs in RNA-based therapies. Major GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-marco-marcia_12180861/2026-11-20T14:00:00+01:002026-11-20T15:00:00+01:00https://www.umu.se/kalender/medkem-seminarserie-silja-wessler_12182734/Medkem seminarserie - Silja WesslerTitel meddelas senareTue, 24 Nov 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Silja Wessler</h3>Department Biosciences and Medical Biology, Microbial Infection and Cancer, Paris-Lodron University Salzburg, Austria Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-silja-wessler_12182734/2026-11-24T15:15:00+01:002026-11-24T16:00:00+01:00https://www.umu.se/kalender/atomic-force-microscopy-course-2026_12183788/Atomic Force Microscopy Course 2026The course on the graduate level offered by NanoLab.Wed, 25 Nov 2026 09:00:00 +0100Hitta mer information (på engelska) och anmäla dig (senast den 19 november 2026) på <a href="/link/de53a5b11e084ae98bc78e15220bc1df.aspx?epslanguage=en" target="_blank" rel="noopener">kursens hemsida</a>.NanoLab, Institutionen för FysikKurs/Utbildninghttps://www.umu.se/kalender/atomic-force-microscopy-course-2026_12183788/2026-11-25T09:00:00+01:002026-11-27T16:00:00+01:00https://www.umu.se/kalender/ssibs-seminar-shahriar-mobashery_12180862/SSIBS seminar: Shahriar MobasheryInom ramen för Integrated Biomedical Sciences Seminars föreläser Shahriar Mobashery, Notre Damme University, USFri, 27 Nov 2026 14:00:00 +0100<h2>Repair Mechanism of Damaged Cell Wall as Target in Antibacterial Strategies</h2>Talare: Shahriar Mobashery, Notre Damme University, USA Värd: Felipe Cava, Institutionen för molekylärbiologi, MIMSFöreläsningen är på engelska<h2>Om föreläsningen:</h2>TBAMajor GrooveSeminariumhttps://www.umu.se/kalender/ssibs-seminar-shahriar-mobashery_12180862/2026-11-27T14:00:00+01:002026-11-27T15:00:00+01:00https://www.umu.se/kalender/medkem-seminarserie-mikhail-kudryashev_12182744/Medkem seminarserie - Mikhail KudryashevTitel meddelas senareTue, 01 Dec 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Mikhail Kudryashev</h3>Max Delbrück Center, Berlin, Germany Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-mikhail-kudryashev_12182744/2026-12-01T15:15:00+01:002026-12-01T16:00:00+01:00https://www.umu.se/kalender/medkem-seminarserie-martin-cohn_12182754/Medkem seminarserie - Martin CohnTitel meddelas senareTue, 08 Dec 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Martin Cohn</h3>Institutionen för molekylärbiologi, UMU Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-martin-cohn_12182754/2026-12-08T15:15:00+01:002026-12-08T16:00:00+01:00https://www.umu.se/kalender/medkem-seminarserie-yolanda-camara_12182762/Medkem seminarserie - Yolanda CámaraTitel meddelas senareTue, 15 Dec 2026 15:15:00 +0100* Seminarium kommer att vara på engelska.Talare:<h3>Yolanda Cámara</h3>Vall d’Hebron Research Institute, Barcelona, Spain Titel meddelas senare Mer information om MedKem-seminarserien och schemat finns <a href="/link/8a7f664146514a36a73f92cd1e776f8b.aspx?epslanguage=sv">här</a>.KB.E3.01 (Lilla hörsalen), KBC-husetSeminariumhttps://www.umu.se/kalender/medkem-seminarserie-yolanda-camara_12182762/2026-12-15T15:15:00+01:002026-12-15T16:00:00+01:00