Main Field of Study and progress level:
Chemistry: Second cycle, in-depth level of the course cannot be classified
Grading scale: Pass with distinction, Pass, Fail
Responsible department: Department of Chemistry
Contents
The objectives of this course are to provide a comprehensive teaching of modern NMR spectroscopy concepts in structural biology related to medically and biologically relevant questions. Main focus will be on a broad understanding of the basics of NMR strategies and their application on the determination of three-dimensional structures of soluble proteins, DNA and RNA molecules, and also insoluble biopolymers such as fibrillar proteins, cartilage, membrane proteins and cell membranes. Students will learn solution and solid state techniques in various laboratory moments using state at of the art equipment with the goal to obtain structural information of important biomolecules. The practical moments will be include the characterization of structural changes couples with biological activities, and modifications induced by drugs and other small molecules which can interact with biological target molecules.
The course contains two major modules containing a thorough theoretical and practical understanding of NMR spectroscopy in biological structure determination. Therefore the course aims to train each student in a way to enable him to work in an individual and independent way to solve NMR based problems in structural biology.
Required Knowledge
Bachelors degree in Chemistry/Biology or Physics/Biophysics, or Medicine/Biomedicine, or the equivalent.
Literature
The literature list is not available through the web.
Please contact the faculty.
