Main Field of Study and progress level:
Chemistry: Second cycle, in-depth level of the course cannot be classified
Grading scale: Pass with distinction, Pass with merit, Pass, Pass with distinction, Pass, Fail
Responsible department: Department of Chemistry
Contents
The course aims to provide an understanding of how the chemical structures and dynamics of organic molecules can be studied by NMR spectroscopy. Fundamental theory of nuclear spin resonance is presented and the concepts of chemical shift, J-coupling, relaxation and the nuclear Overhauser effect (NOE) are discussed. Vector models are used throughout the course as a tool for analysing the different sequencies of pulses employed in common NMR techniques. Emphasis is given to applications and practical exercises, both computer-based and instrumental. In particular, experimental work is directed to the collection and interpretation of data and the analysis of different procedures for determining the structures of organic molecules, and includes one-dimensional 1H- och 13C-methods as well as 2-dimensional experiments such as COSY, TOCSY and heteronuclear measurements. The course concludes with a project in which the student examines the structure of an organic compound using the methods and interpretation procedures covered in the course.
Required Knowledge
Univ.: Bioorganic Chemistry (5KE010 or 5KE011, 15 hp), or the equivalent.
Proficiency in English equivalent to Swedish upper secondary course English A (IELTS (Academic) with a minimum overall score of 5.5 and no individual score below 5.0. TOEFL PBT
(Paper-based Test) with a minimum total score of 530 and a minimum TWE score of 4. TOEFL iBT (Internet-based Test) with a minimum total score of 72 and a minimum score of 17 on the Writing Section).
Where the language of instruction is Swedish, applicants must prove proficiency in Swedish to the level required for basic eligibility for higher studies.
