Main Field of Study and progress level:
Chemistry: Second cycle, in-depth level of the course cannot be classified
Grading scale: Pass with distinction, Pass with merit, Pass, Pass with distinction, Pass, Fail
Responsible department: Department of Chemistry
Contents
The course aims to provide an understanding of how the chemical structures and dynamics of organic molecules can be studied by NMR spectroscopy. Fundamental theory of nuclear spin resonance is presented and the concepts of chemical shift, J-coupling, relaxation and the nuclear Overhauser effect (NOE) are discussed. Vector models are used throughout the course as a tool for analysing the different sequencies of pulses employed in common NMR techniques. Emphasis is given to applications and practical exercises, both computer-based and instrumental. In particular, experimental work is directed to the collection and interpretation of data and the analysis of different procedures for determining the structures of organic molecules, and includes one-dimensional 1H- och 13C-methods as well as 2-dimensional experiments such as COSY, TOCSY and heteronuclear measurements. The course concludes with a project in which the student examines the structure of an organic compound using the methods and interpretation procedures covered in the course.
Required Knowledge
Univ.: Bioorganic Chemistry (5KE010 or 5KE011, 15 hp), or the equivalent. English proficiency equivalent to IELTS Academic Training minimum score 5.0 with no individual score below 4.5 (tests taken before January 2005 not admissible) or TOEFL minimum score 500 on paper based test and not below 4.0 on the TWE, Alternatively 173 on computer based test with iBT61 is also required as well as basic entrance requirements for higher studies in Swedish language proficiency if the course is taught in Swedish.
