Stress Response Modeling at IceLab guest researcher Karl Kochanowski will give a talk in IceLab titled 'Predicting in vivo metabolic vulnerabilities in Streptococcus suis using metabolic models' on April 25th at 13.30, in IceLab and in Zoom.
Streptococcus suis is an important zoonotic pathogen causing severe systemic infections in pigs as well as humans. Recent genomic evidence from large clinical isolate collections suggests that metabolism plays a key role in S. suis pathogenicity. To explore the relationship between genomic variability, metabolism, and pathogenicity in S. suis in more detail, we developed the first large-scale ensemble of strain-specific S. suis genome-scale metabolic models. In my talk, I will discuss how these models can be used to identify new metabolic vulnerabilities that are conserved across clinical isolates and relevant in vivo, thus paving the way for new treatment strategies which directly target S. suis metabolism.
Drop in to IceLab (find using mazemap) or join via Zoom: IceLab Living Room Zoom 612 568 7586
Dr. Karl Kochanowski is a Ramón y Cajal researcher at IRTA-CReSA in Barcelona (Spain). His research aims to elucidate the principles of cellular metabolic regulation and understand their impact on disease outcomes. During his PhD research at ETH Zurich (Switzerland), he explored the role of protein-metabolite interactions in coordinating metabolic pathway activity in Escherichia coli. During his postdoctoral research at the University of California, San Francisco (USA), he investigated how changes in nutrient availability affect cancer cell behavior.
At IRTA-CReSA, he and his team use a variety of experimental and computational systems biology approaches (e.g. high-throughput cultivation, metabolomics, and genome-scale metabolic models) to tackle three research lines, namely 1) the systematic mapping of metabolic interactions within the nasal microbiota, 2) the identification of new metabolic targets against respiratory bacterial pathogens, and 3) the development of an animal organoid biobank tailored towards infection biology studies.
IRTA-CReSA Animal Health Research Center, Barcelona, Spain
Stress Response Modeling at IceLab Guest Researcher