Dragomira Majhen, Ruđer Bošković Institute, Zagreb, Croatia
Host: Niklas Arnberg, Department of Clinical Microbiology
The seminar is open to all interested.
Find the lecture room: Mazemap
Abstract:
The field of adenovirus biology is rapidly advancing due to the increasing use of adenoviruses in vaccine development, as well as in gene and cancer therapy. Recombinant adenoviral vectors are efficient carriers of transgenes because they mimic natural infection and induce strong humoral and cellular immune responses, along with a pronounced adjuvant effect. The recent approval of several adenovirus-based vaccines by the European Medicines Agency has further highlighted the importance of human adenovirus type 26 (HAdV-D26), whose basic biology remains incompletely understood.
In her lecture, Dragomira Majhen will present our results demonstrating that HAdV-D26 uses integrin αvβ3 as a receptor for entry into epithelial cells, can employ multiple mechanisms of cellular entry, and induces a proinflammatory response dependent on integrin αvβ3 and the NF-κB signaling pathway. I will also address the role of Rab9 in HAdV-D26 transduction efficiency, as well as the role of TLR3 in the induction of the innate immune response by HAdV-D26.