Our research group studies LRIG proteins and the regulation of cancer cell growth.
The LRIG (Leucine-rich repeats and immunoglobulin-like domains) gene and protein family was discovered two decades ago by our research group. LRIG1 functions as a tumor suppressor in breast, prostate, brain, intestines, and other tissues. Our research focuses on understanding the molecular mechanisms behind the tumor suppressive functions of LRIG proteins with the view of developing new treatment strategies for common human cancers.
We also apply advanced animal models to investigate the genetic basis behind treatment resistance in gynecological cancers. The overarching goal of our research is to provide means for better treatment of cancer patients.
Molecular regulation of growth factor signaling in cancer cells
The clinical importance of LRIG proteins in human cancer