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Image: Mattias Pettersson

Håkan Hedman Lab

Research group Our research group studies LRIG proteins and the regulation of cancer cell growth.

The LRIG (Leucine-rich repeats and immunoglobulin-like domains) gene and protein family was discovered two decades ago by our research group. LRIG1 functions as a tumor suppressor in breast, prostate, brain, intestines, and other tissues. Our research focuses on understanding the molecular mechanisms behind the tumor suppressive functions of LRIG proteins with the view of developing new treatment strategies for common human cancers.

We also apply advanced animal models to investigate the genetic basis behind treatment resistance in gynecological cancers. The overarching goal of our research is to provide means for better treatment of cancer patients.


Molecular regulation of growth factor signaling in cancer cells


The clinical importance of LRIG proteins in human cancer


Novel treatment strategies in ovarian carcinoma

Head of research

Håkan Hedman
Adjunct professor


Participating departments and units at Umeå University

Department of Radiation Sciences

Research area


External funding

Swedish Cancer Society, Cancerforskningsfonden Norrland, The Kempe Foundation, Region Västerbotten

External funding

Latest update: 2023-03-03