Research group We are applying tissue engineering and regenerative medicine principles to understand how we can repair injuries in the nervous system and other types of tissue defects.
Regenerative medicine with adipose tissue-derived stem cells (ASCs) harnesses the body’s own fat tissue to promote healing and tissue repair. These stem cells are easily accessible and can be stimulated to release bioactive molecules and extracellular vesicles (EVs) that support regeneration of various tissues including nerves, muscles, and blood vessels.
We investigate the biology of different sub-populations of ASCs with the aim to uncover differences in their regenerative potential and functional characteristics. For example, we have shown that pericyte-like cells have superior angiogenic and adipogenic properties compared to others. By isolating and characterizing these distinct cell types, we can better tailor stem cell therapies for specific clinical applications. Furthermore, we study the effect of different types of culture conditions on the cells with the view to maximising therapeutic outcomes.
EVs, such as exosomes, are nano-sized particles naturally released by cells that carry bioactive molecules such as proteins, mRNAs, and microRNAs. We are investigating these cargoes in ASC-derived EVs with a view to understanding how these particles can promote nerve axon regeneration and angiogenesis and prevent muscle degeneration. Unlike whole-cell therapies, EVs offer a cell-free approach that reduces risks associated with cell transplantation.
Bioprinting is an advanced technique in regenerative medicine that enables the precise layering of cells and biomaterials to create tissue-like structures. In skin regeneration, bioprinting allows for the fabrication of multi-layered constructs that mimic the architecture of natural skin, including the epidermis, dermis, and vascular networks. We are working with this technology to develop better in vitro models to understand mechanisms in wound healing and cancer.
Collectively, our work aims for the development of safer, more effective advanced therapies for regeneration and tissue reconstruction, with a strong emphasis on clinical feasibility and innovation. Our work is also facilitated by access to modern clean room infrastructure at the University Hospital of Umeå.
