Image: Jan Johnson
Research group We have cloned the genes for human LRIG1-3, which constitute a gene family and are predicted to encode integral cell membrane proteins with cellular 15 leucine-rich repeats and immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail.
LRIG1 has been detected in mouse glial cells while, in man, we have shown extensive expression of LRIG1/2, mRNA and proteins in normal tissues and some tumour cells.
The study shows that palliative patients neither live longer nor experience improved quality of life.
