Image: Mattias Pettersson
Image: Mattias Pettersson
Research project financed by the by the Knut and Alice Wallenberg Foundation.
This project aims at mapping and modulating the function of the proteome of the largely uncharacterized archaeal species of the human microbiome.
Our human gut microbiome plays an important role for human health. Most gut microbiome research focuses on bacterial species, but some archaeal species are also quite prevalent. The impact of these species on health and disease remains unclear, even though certain archaeal species trigger host immune responses and play significant metabolic roles, such as degrading toxic bacterial metabolites.
In this project, we want to use a systems biology approach based on proteomics to determine protein function at scale. This will be achieved by measuring phenotypical responses to drug-like compounds, and then using a subset of these compounds as tools to modulate protein function. Ultimately, the results of this project will enable us to develop strategies to manipulate microbiome species composition to uncover the role of archaeal species in the gut microbiome.
