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Staff photo Åsa Gylfe

Åsa Gylfe

I am researching to find small molecules that can be developed into new drugs against infections. Specifically, I focus on molecules that have an effect on chlamydia bacteria.

Contact

Works at

Affiliation
Assistant professor, consultant (attending) physician at Department of Clinical Microbiology Units: Clinical Bacteriology, Section of Infection and Immunology
Location
By 6 B, Klin bakteriologi, Universitetssjukhuset Umeå universitet, 901 85 Umeå
Affiliation
Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS)
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

Chlamydia are significant human pathogens, causing infertility and blindness globally. There are more than 100 million annual cases of sexually transmitted C. trachomatis worldwide and almost as many people receive treatment for trachoma, a blinding eye infection. Treatment options are limited to broad-spectrum antibiotics that select for antibiotic resistance in other human pathogenic bacteria. Chlamydia readily develop resistance to antibiotics in vitro and it may become a clinical problem.

The goal of my research is to identify small molecules that can be further developed into new drugs against infections. The project can ultimately lead to new treatment options for Chlamydia and for other infections. At the same time, it can reduce the development of resistance and prevent globally occurring disabling diseases.

Journal of the National Cancer Institute
Lu, Sai San Moon; Mohammed, Zahraa; Häggström, Christel; et al.
Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2021, Vol. 65, (5)
Núñez-Otero, Carlos; Bahnan, Wael; Vielfort, Katarina; et al.
JOURNAL OF FUNGI, MDPI 2020, Vol. 6, (4)
Risum, Malene; Helweg-Larsen, Jannik; Petersen, Soren Lykke; et al.
MedChemComm, Royal Society of Chemistry 2019, Vol. 10, (11) : 1966-1987
Kulén, Martina; Núñez-Otero, Carlos; Cairns, Andrew G.; et al.
PLOS ONE, Public Library of Science 2019, Vol. 14, (5)
Müller, Daniel C.; Kauppi, Anna; Edin, Alicia; et al.
Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC) 2018, Vol. 24, (6) : 1141-1142
Gylfe, Åsa; Ribers, Åsa; Forsman, Oscar; et al.
Frontiers in Microbiology, Frontiers Media S.A. 2018, Vol. 9
Mojica, Sergio; Eriksson, Anna U.; Davis, Rohan A.; et al.
European Journal of Medicinal Chemistry, Elsevier 2018, Vol. 143 : 1077-1089
Saleeb, Michael; Mojica, Sergio; Eriksson, Anna U.; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2017, Vol. 60, (22) : 9393-9399
Good, James A. D.; Kulén, Martina; Silver, Jim; et al.
Läkartidningen, Stockholm: 2017, Vol. 114
Gylfe, Åsa; Cajander, Sara; Wahab, Tara; et al.
Antimicrobial Agents and Chemotherapy, American society for microbiology 2017, Vol. 61, (10)
Mojica, Sergio A.; Salin, Olli; Bastidas, Robert J.; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2016, Vol. 59, (5) : 2094-2108
Good, James A. D.; Silver, Jim; Núñez-Otero, Carlos; et al.
PLOS ONE, Vol. 11, (1)
Kauppi, Anna M.; Edin, Alicia; Ziegler, Ingrid; et al.
Vector Borne and Zoonotic Diseases, Vol. 15, (2) : 133-140
Bergqvist, Joakim; Forsman, Oscar; Larsson, Pär; et al.
European Journal of Medicinal Chemistry, Vol. 101 : 595-603
Sunduru, Naresh; Salin, Olli; Gylfe, Åsa; et al.
Journal of Bacteriology, American Society for Microbiology 2014, Vol. 196, (16) : 2989-3001
Bao, Xiaofeng; Gylfe, Åsa; Sturdevant, Gail L.; et al.
Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2014, Vol. 58, (5) : 2968-2971
Marwaha, Sania; Uvell, Hanna; Salin, Olli; et al.
Journal of Bacteriology, Washington DC, USA: American Society for Microbiology 2013, Vol. 195, (18) : 4221-4230
Engström, Patrik; Nguyen, Bidong D.; Normark, Johan; et al.
Bioorganic & Medicinal Chemistry Letters, Elsevier 2012, Vol. 22, (10) : 3550-3553
Enquist, Per-Anders; Gylfe, Åsa; Hägglund, Ulrik; et al.
Planta Medica, Georg Thieme Verlag KG 2012, Vol. 78, (11) : 1102-1102
Pohjala, L.; Uvell, Hanna; Hakala, E.; et al.
Advances in Yersinia Research, Springer 2012 : 349-356
Ur-Rehman, Tofeeq; Nordfelth, Roland; Blomgren, Anders; et al.
The Journal of antibiotics, Vol. 65 : 397-404
Ur-Rehman, Tofeeq; Slepenkin, Anatoly; Chu, Hencelyn; et al.
Bioorganic & Medicinal Chemistry, Vol. 18, (7) : 2686-2703
Dahlgren, Markus K; Zetterström, Caroline E; Gylfe, Åsa; et al.
Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 29, (10) : 1478-1480
Ovchinnikova, Olga; Gylfe, Åsa; Bailey, Leslie; et al.
Epidemiology and Infection, New York: Cambridge University Press 2009, Vol. 137, (12) : 1816-1824
Steptoe, A; Gylfe, Åsa; Shamaei-Tousi, A; et al.
Umeå University medical dissertations, N.S., 740
Gylfe, Åsa
Journal of Clinical Microbiology, Vol. 37, (4) : 890-896
Gylfe, Åsa; Olsen, Björn; Strasevicius, Darius; et al.

Research groups

Head of research
Åsa Gylfe Lab