The project focuses on determining the role of inclusions in counteracting host cellular defense response and in regulating Chlamydia development. So in general, studying the role of Chlamydia inclusion in evasion of cell-autonomous immunity by using different molecular biologic and microscopic techniques, and thereby also expanding the experimental toolkit for Chlamydia.
Paulikat, Antje & Tölken, Lea & Jachmann, Lana & Burchhardt, Gerhard & Hammerschmidt, Sven & Siemens, Nikolai. (2022): Streptococcus pneumoniae Impairs Maturation of Human Dendritic Cells and Consequent Activation of CD4+ T Cells via Pneumolysin. Journal of Innate Immunity. 1-12. 10.1159/000522339.
Surabhi, Surabhi & Jachmann, Lana & Lalk, Michael & Hammerschmidt, Sven & Methling, Karen & Siemens, Nikolai. (2021): Bronchial Epithelial Cells Accumulate Citrate Intracellularly in Response to Pneumococcal Hydrogen Peroxide. ACS infectious diseases. 7. 10.1021/acsinfecdis.1c00372.
Surabhi, Surabhi & Jachmann, Lana & Shumba, Patience & Burchhardt, Gerhard & Hammerschmidt, Sven & Siemens, Nikolai. (2021): Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells. Journal of innate immunity. 1-15. 10.1159/000517855.