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Staff photo Lars Thelander

Lars Thelander

Making the building blocks to the genome

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Affiliation
Affiliated as professor emeritus at Department of Medical Biochemistry and Biophysics
Location
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

The enzyme ribonucleotide reductase synthesize the building blocks to DNA. We want to understand how this synthesis is regulated in various organisms. We also study the nucleotide metabolism in Trypanosoms, a parasite that causes African sleeping sickness, with the goal to find new drug-targets.

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
Journal of Biological Chemistry, Vol. 287, (21) : 17628-17636
Ranjbarian, Farahnaz; Vodnala, Munender; Vodnala, Sharvani Munender; et al.
Biochemistry, Vol. 48, (27) : 6532-6539
Popović-Bijelić, Ana; Voevodskaya, Nina; Domkin, Vladimir; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2008, Vol. 105, (46) : 17801-17806
Pontarin, Giovanna; Fijolek, Artur; Pizzo, Paola; et al.
Journal of biological chemistry, Vol. 282, (16) : 11858-11865
Fijolek, Artur; Hofer, Anders; Thelander, Lars
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2007, Vol. 282, (23) : 16820-16828
Pontarin, Giovanna; Ferraro, Paola; Håkansson, Pelle; et al.
Nature. Genetics, Vol. 39, (6) : 703-4
Thelander, Lars
Journal of Biological Chemistry, Vol. 281, (3) : 1778-1783
Håkansson, Pelle; Dahl, Lina; Chilkova, Olga; et al.
Journal of Biological Chemistry, Vol. 281, (12) : 7834-7841
Håkansson, Pelle; Hofer, Anders; Thelander, Lars
Journal of biological chemistry, Vol. 281, (36) : 26022-8
Narváez, Ana J; Voevodskaya, Nina; Thelander, Lars; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, (26) : 9850-4
Voevodskaya, N; Narvaez, A-J; Domkin, Vladimir; et al.
Journal of biological chemistry, Vol. 279, (11) : 10796-807
Chabes, Anna Lena; Björklund, Stefan; Thelander, Lars
Journal of virology, Vol. 78, (8) : 4278-88
Lembo, David; Donalisio, Manuela; Hofer, Anders; et al.
Cell, Vol. 112, (3) : 391-401
Chabes, Andrei; Georgieva, Bilyana; Domkin, Vladimir; et al.
Cell Cycle, Vol. 2, (3) : 171-3
Chabes, Andrei; Thelander, Lars
Proc. Natl. Acad. Sci. U S A., Vol. 100, (7) : 3925-3929
Chabes, Anna Lena; Pfleger, C.M.; Kirschner, M.W.; et al.
European Journal of Biochemistry, Blackwell Publishing 2003, Vol. 270, (8) : 1791-1801
Kotova, Irina; Chabes, Anna Lena; Lobov, Sergei; et al.
Journal of Biological Chemistry, Vol. 277, (21) : 18574-8
Domkin, Vladimir; Thelander, Lars; Chabes, Andrei
Cell, Vol. 109, (5) : 563-73
Saitoh, Shigeaki; Chabes, Andrei; McDonald, W Hayes; et al.
Journal of Biological Chemistry, Vol. 276, (44) : 40647-40651
Guittet, Olivier; Håkansson, Pelle; Voevodskaya, Nina; et al.
Proceedings of the National Academy of Sciences of the U S A, Vol. 98, (11) : 6412-6
Hofer, Anders; Steverding, D; Chabes, Andrei; et al.
European Journal of Biochemistry, Vol. 268, (16) : 4527-4536
Kotova, Irina; Chabes, Anna Lena; Segerman, Bo; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, (6) : 2474-2479
Chabes, Andrei; Domkin, Vladimir; Larsson, Göran; et al.
Journal of Virology, Vol. 74, (24) : 11557-65
Lembo, D; Gribaudo, G; Hofer, Anders; et al.
Biochemistry, Vol. 38, (12) : 3610-4
Hayakawa, H; Hofer, Anders; Thelander, Lars; et al.
Journal of Biological Chemistry, Vol. 273, (51) : 34098-104
Hofer, Anders; Ekanem, J T; Thelander, Lars
Journal of Biological Chemistry, Vol. 273, (45) : 29816-21
Johansson, Erik; Hjortsberg, K; Thelander, Lars
Proceedings of the National Academy of Sciences of the U S A, Vol. 94, (13) : 6959-64
Hofer, Anders; Schmidt, P P; Gräslund, Astrid; et al.
Journal of Biological Chemistry, Vol. 271, (39) : 23698-704
Filatov, D; Björklund, Stefan; Johansson, Erik; et al.
Journal of Biological Chemistry, Vol. 270, (50) : 30162-7
Johansson, Erik; Skogman, E; Thelander, Lars
Advances in Experimental Medicine and Biology, Vol. 370 : 721-4
Johansson, Erik; Björklund, Stefan; Thelander, Lars
Proceedings of the National Academy of Science U S A, Vol. 90, (23) : 11322-6
Björklund, Stefan; Hjortsberg, K; Johansson, Erik; et al.
EMBO Journal, Vol. 11, (13) : 4953-4959
Björklund, Stefan; Skogman, E; Thelander, Lars
Biochemistry, Vol. 29, (23) : 5452-5458
Björklund, Stefan; Skog, Sven; Tribukait, Bernard; et al.

Research groups

Head of research
Lars Thelander