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Umeå University
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Syllabus:

Bacterial Pathogenesis, 15 Credits

The course is discontinued from 2023-06-06

Swedish name: Bakteriell patogenes

This syllabus is valid: 2008-01-14 valid to 2011-08-28 (newer version of the syllabus exists)

Course code: 5MO027

Credit points: 15

Education level: Second cycle

Main Field of Study and progress level: Molecular Biology: Second cycle, has only first-cycle course/s as entry requirements

Grading scale: Three-grade scale

Responsible department: Department of Molecular Biology

Contents

The course contents include the molecular mechanisms for adaptation of pathogenic microorganisms to changing environmental conditions, especially when they invade and establish themselves in other organisms, particularly man. Different bacterial virulence mechanisms that contribute to pathogenicity are demonstrated. Other features include characterisation of microbe-host interactions, comparisons between pathogenic and non-pathogenic bacterial isolates, and demonstration of virulence properties and physiological processes of importance for a specific infection. Different systems for regulation of bacterial virulence-associated properties will also be studied, such as how microorganisms utilize changes in environmental parameters such as temperature, salinity, oxygen pressure, pH, anaerobiosis, and nutrient levels as a means to alter virulence gene expression during host infections. The course will also cover the different defense mechanisms with which host organisms defend themselves against pathogenic microorganisms. Lastly, the course will highlight mechanisms of action of antibiotics and the molecular basis for the alarming rise in strains of multiple drug-resistant bacteria.

Required Knowledge

Special requirements: For those not being native English speakers, an internationally recognized test of English proficiency is required: an IELTS of at least 6.0, no score below 5.0 or a TOEFL score of 550 PB/213 CB/79 iBT (equivalent to English B in Sweden) is required. Applicants who have at least two years of university studies in Australia, Canada, Great Britain, New Zealand, or the USA fulfil the requirement for English B. Alternatively, if the medium of instruction in the Bachelor education has been English, an attested copy certifying that would be sufficient. Additional requirements are: Thirty ECTS-credits in Chemistry, with a minimum of 7,5 ECTS-credits in Biochemistry; 45 ECTS-credits in Life Sciences, including a minimum of 7.5 ECTS-credits in each of Genetics and Microbiology, and in total a minimum of 15 ECTS-credits in Plant- and Animal Physiology, and Cell- and Molecular Biology; practical experience of laboratory work, corresponding to a minimum of 30 ECTS-credits; and the 15 ECTS-credits course Advanced Microbiology (MOLC11).

Literature

The literature list is not available through the web. Please contact the faculty.