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Syllabus:

Bacterial Pathogenesis, 15 Credits

The course is discontinued from 2023-06-06

Swedish name: Bakteriell patogenes

This syllabus is valid: 2011-09-12 and until further notice

Course code: 5MO027

Credit points: 15

Education level: Second cycle

Main Field of Study and progress level: Molecular Biology: Second cycle, has only first-cycle course/s as entry requirements

Grading scale: Three-grade scale

Responsible department: Department of Molecular Biology

Revised by: Faculty Board of Science and Technology, 2023-06-06

Contents

The course contents include the molecular mechanisms for adaptation of pathogenic microorganisms to changing environmental conditions, especially when they invade and establish themselves in other organisms, particularly man. Different bacterial virulence mechanisms that contribute to pathogenicity are demonstrated. Other features include characterisation of microbe-host interactions, comparisons between pathogenic and non-pathogenic bacterial isolates, and demonstration of virulence properties and physiological processes of importance for a specific infection. Different systems for regulation of bacterial virulence-associated properties will also be studied, such as how microorganisms utilize changes in environmental parameters such as temperature, salinity, oxygen pressure, pH, anaerobiosis, and nutrient levels as a means to alter virulence gene expression during host infections. The course will also cover the different defense mechanisms with which host organisms defend themselves against pathogenic microorganisms. Lastly, the course will highlight mechanisms of action of antibiotics and the molecular basis for the alarming rise in strains of multiple drug-resistant bacteria.

Required Knowledge

Proficiency in English equivalent to Swedish upper secondary course English B (IELTS (Academic) with a minimum overall score of 6.5 and no individual score below 5.5. TOEFL PBT (Paper-based Test) with a minimum score of 575 and a minimum TWE score of 4.5). TOEFL iBT (Internet-based Test) with a minimum score of 90 and a minimum score of 20 on the Writing Section).Additional requirements are: Thirty ECTS-credits in Chemistry, with a minimum of 7,5 ECTS-credits in Biochemistry; 45 ECTS-credits in Life Sciences, including a minimum of 7.5 ECTS-credits in each of Genetics and Microbiology, and in total a minimum of 15 ECTS-credits in Plant- and Animal Physiology, and Cell- and Molecular Biology; practical experience of laboratory work, corresponding to a minimum of 30 ECTS-credits; and the 15 ECTS-credits course Advanced Microbiology (MOLC11).

Literature

The literature list is not available through the web. Please contact the faculty.