Speaker: Mary Anne O'Connell, Central European Institute of Technology (CEITEC), Masaryk University, Czechia
Mary Anne O'Connell lab website
Host: Francesca Aguilo, Department of Molecular Biology
About the lecture: The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) modifies double-stranded (ds) RNA by deaminating adenosine to inosine (A-to-I). Inosine in dsRNA helps the cell to distinguish self from non-self RNA thus preventing aberrant activation of the dsRNA antiviral immune sensors. ADAR1 also can have protein-protein interactions with Protein Kinase R (PKR) another dsRNA sensor to prevent its activation. We have expanded our study of ADAR1 and now observe that it also plays an important role in adaptive immunity.
Find your way: Regarding the lecture hall 5B P6 Stora hörsalen, it is located in the hospital premises. Mazemap link for hörsalen is https://link.mazemap.com/rGiySLeg
Integrated Biomedical Science Seminars is a broad, open seminar series within life science.