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Selected publications

  1. Sean M Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono (2020). MALT-1 Mediates IL-17 Neural Signaling to Regulate C. Elegans Behavior, Immunity and Longevity. Nat Commun. DOI: 10.1038/s41467-020-15872-y. PMID: 32350248.

  2. Isabel Beets, Gaotian Zhang, Lorenz Fenk, Changchun Chen, Geoffrey M. Nelson, Marie-Anne Félex, Mario de Bono (2020). Natural variation in a dendritic scaffold protein modifies experience-dependent plasticity by altering neuropeptide expression. Neuron. doi: 10.1016/j.neuron.2019.10.001. PMID: 31757604.

  3. Laurent P, Ch'ng Q, Jospin M, Chen C, Lorenzo R, de Bono M (2018). Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1714610115. PMID: 29959203.

  4. Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. 2017. doi: 10.1038/nature20818. PubMed PMID: 28099418.

  5. Laurent P, Soltesz Z, Nelson G, Chen C, Arellano-Carbajal F, Levy E, de Bono M (2015) Decoding a neural circuit controlling global animal state in C. elegans. eLife 4, 04241. PMID: 25760081.

  6. Karlsborn T, Tukenmez H, Chen C, Byström AS (2014). Familial dysautonomia (FD) patients have reduced levels of the modified wobble nucleoside mcm5s2U in tRNA. Biochem Biophys Res Commun 454:441–445. PMID: 25450681.

  7. Chen C, Itakura E, Weber KP, Hegde RS, de Bono M (2014) An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism. PLoS Genet 10(3): e1004082. PMID: 24603482.

  8. Chen C, Fenk LA, de Bono M (2013) Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination. Nucleic Acids Res. 41: e193. PMID: 24013562.

  9. Zhou Y*, Chen C*, Johansson MJ (2013) The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression. Nucleic Acids Res 41: 5669–5678. PMID: 23605039.

  10. Chen C, Huang B, Eliasson M, Rydén P, Byström AS (2011) Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification. PLoS Genet 7(9): e1002258. PMID: 21912530.

  11. Chen C, Huang B, Anderson JT, Byström AS (2011) Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U. PLoS ONE 6(6): e20783. PMID: 21687733.

  12. Kim S, Johnson W, Chen C, Sewell AK, Bystrom AS, Han M (2010) Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Genetics 185, 1235–1247. PMID: 20479142.

  13. Chen C, Tuck S, Byström AS (2009) Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants. PLoS Genet 5(7): e1000561. PMID: 19593383.