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Selected publications

Norlin, S., Parekh, V.S., Naredi, P., Edlund, H. Asna1/TRC40 controls beta cell function and ER homeostasis by ensuring retrograde transport. Diabetes. 2015 Oct 5. [Epub ahead of print]

Sharma, S.K., Chorell, E., Steneberg, P., Vernersson-Lindahl, E., Edlund, H., Wittung-Stafshede, P. Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner. Scientific Rep. 5:12531, 2015

Steneberg, P., Sykaras, A.G., Backlund, F., Straseviciene, J., Söderström, I., Edlund H. Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance. J Biol Chem. 290:19034-19043, 2015

Gao, T., McKenna, B., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N., Edlund, H., Matschinsky, F., Stein, R., and Stanger, B.Z. Pdx1 maintains β-cell identity and function by repressing an α-cell program. Cell Metabolism 19:259–271, 2014

Steneberg, P., Bernardo, L., Edfalk, S., Backlund, F., Lundberg, L., Östenson, C.G., and Edlund, H. The type 2 diabetes associated gene Ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes 62: 2004-2014 2013

Medina, M.C., Molina, J., Gadea, Y., Fachado, A., Murillo, M., Simovic, G., Pileggi, A., Hernández, A., Edlund, H., and Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology 152:3717-3727. 2011

Svensson P, Bergqvist I, Norlin S, and Edlund H. MFng is dispensable for mouse pancreas development and function. Mol Cell Biol. 8:2129-2138, 2009. (Epub 2009 Feb 17.)

Correa-Medina, M., Bravo-Egana, V., Rosero, S., Ricordi, C., Edlund, H., Diez, J., and Pastori, R.L. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expression Patterns 4,193-199 2009 (Epub ahead of print 2008 Dec 24)

Boucher, M-J., Simoneau, M., and Edlund, H. The homeodomain-interacting protein kinase 2 (HIPK2) regulates IPF1/PDX1 transcriptional activity. Endocrinology, 150:87-97, 2009 (Epub 2008 Sep 4)

Öström, M., Loffler, K. A., Edfalk, S, Selander, L, Dahl, U., Ricordi, C., Jeon. J., Correa-Medina, M., Diez, J., and Edlund, H. Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and their Further Differentiation into -cells. PLoSONE 3:e2841, 2008.

Edfalk, S., Steneberg, P., and Edlund, H. Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion. Diabetes 57:2280-2287, 2008.

Svensson, P., Williams, C., Lundeberg, J., Ryden, P., Bergqvist, I., and Edlund, H. Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC developmental biology 7: 129, 2007.

Goulley, J., Dahl.U., Beaza, N., Mishina, Y., and Edlund H. BMP4-BMPRIA signalling in cells is required for and augments glucose stimulated insulin secretion. Cell Metabolism , 5, 207-219, 2007.

Boucher, M-J., Selander, L, Carlsson, L, and Edlund, H. Phosphorylation marks IPF1/PDX1 protein for degradation by GSK3-dependent mechanisms. JBC 281, 6395-6403, 2006.

Papadopoulou, S., and Edlund, H. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatc function. Diabetes, 54:2844-2851, 2005.

Steneberg, P., Rubins, N., Bartoov-Shifman, R., Walker, M.D. Edlund, H. The FFA-receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metabolism, 1, 245-258, 2005.

Norlin, S., Ahlgren, U., Edlund, H. NF B activity in ?-cells is required for glucose stimulated insulin secretion. Diabetes 54:125-132, 2005.

Edlund H. Islet Differentiation and Development - A Background for Stem Cell Therapy. International Diabetes Monitor, 16:10-17, 2004.

Hart, A.W., Papadopoulou, S., and Edlund, H. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev. Dyn. 228:185-193 2003.

Edlund H. Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532, 2002.

Selander, L., and Edlund, H. Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas. Mech. of Dev., 113:189-192, 2002.

Hart, A.W., Baeza, N., Apelqvist, Å., Edlund, H.: Attenuation of FGF-signaling in Mouse -cells Leads to Diabetes. Nature 408:864-868, 2000.

Li H, Arber S, Jessell TM and Edlund H. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hb9. Nat Genet 23:67-70, 1999.

Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U and Edlund H. Notch-signalling controls pancreatic cell fate differentiation. Nature 400:877-881, 1999.

Ahlgren U, Johnsson J, Johnsson L, Simu K and Edlund H. Beta-cell-specific inativation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes & Dev 12:1763-1768, 1998.

Ahlgren U, Pfaff SL, Jessells TM, Edlund T and Edlund H. Independent requirement for ISL1 in the formation of pancreatic mesenchyme and islet cells. Nature 385:257-260, 1997.

Apelqvist A, Ahlgren, U and Edlund H. Sonic hedgehog directs specialized mesoderm differentiation in the intestine and pancreas. Curr Biol 7:801-804, 1997.

Ahlgren U, Jonsson J, and Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409-1416, 1996.

Jonsson J, Carlsson L, Edlund T, and Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609, 1994.