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Regenerative Endodontics and Oral Infection Biology

Research group Our research focuses on developing biologically based therapies to preserve natural teeth and understanding how key pathogens and microbial communities influence health and disease. We investigate regenerative endodontics, host–microbe interactions, and the role of the oral and root canal microbiomes in oral infections and their potential impact on systemic health.

Regenerative endodontics – new approaches to tooth preservation

We develop and evaluate biologically based therapies for teeth with damaged or infected dental pulp. A particular focus is regenerative endodontics, which aims to stimulate the body's natural healing mechanisms and promote further root development in young patients. Through clinical studies, we investigate long-term treatment outcomes and explore new strategies, including probiotics, to improve treatment success.

Oral microbiome and host–microbe interactions

We investigate the root canal and oral microbiomes to understand how microorganisms contribute to infection, inflammation, and healing. Using microbiological and molecular approaches, we study microbial communities, their biological properties, and interactions with host tissues. Our goal is to identify factors associated with disease progression and treatment outcomes, providing a foundation for more targeted therapies.

Oral infections and systemic health

Another important area of our research explores the potential links between oral infections and systemic diseases, particularly cardiovascular diseases and infective endocarditis. We investigate how oral microorganisms may contribute to infections beyond the oral cavity and the potential role of endodontic infections. Through clinical and microbiological studies, we aim to improve our understanding of these associations and support better preventive strategies.

Head of research

Nelly Romani Vestman
Associate professor, senior consultant dentist
E-mail
Email

Overview

Participating departments and units at Umeå University

Department of Odontology

Research area

Odontology
Latest update: 2026-10-15