Research project Why do we have several different pathways to metabolize anandamide and 2-arachidonoylglycerol? My research group is investigating this question at the level of basic science.
Anandamide and 2-arachidonoylglycerol are two endogenous lipid signalling molecules responsible for effects as diverse as control of appetite, pain and cancer. As with all signalling molecules, the body has effective metabolic pathways for their synthesis and removal. With respect to the latter, they are metabolised primarily by hydrolysis to their corresponding long-chain fatty acids. However, they are also substrates for cyclooxygenase-2 to produce compounds that themselves are biologically active. The research project investigates the importance of these pathways, and how they can selectively be targeted.
The Swedish Research Council, 2003-2018: SEK 12,648,000
The Swedish Cancer Society, 2011-2013: SEK 1,500,000