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Andreas Kohler

Assistant Professor of Medical Biochemistry

Equal Opportunities Representative of the Department of Medical Biochemistry and Biophysics

Mitochondria are vital parts of our cells that play a major role in energy conversion. Thereby, they apply oxygen from the air we breathe and metabolites derived from our food to produce ATP, the main form of energy used in our cells. This makes mitochondria the foundation of all oxygen-dependent life on Earth. Interestingly, mitochondria originated as separate organisms and were incorporated into our cells during evolution. Thus, they contain their own DNA, which codes for proteins that are essential for the energy conversion process.

To ensure that proteins function properly, they are monitored by complex systems in a process known as protein quality control (PQC). PQC ensures accurate protein production, proper transport and placement within the cell, correct folding into functional proteins, and, if necessary, breakdown of damaged or surplus proteins. This is particularly important for mitochondria, as their oxidative environment can damage proteins and disrupt cellular functions. Indeed, the accumulation of such damage is associated with ageing and can result in age-related diseases, including cancer and neurodegenerative disorders like Parkinson’s disease. However, many aspects of mitochondrial PQC are still unknown, especially PQC of proteins encoded by mitochondrial DNA remains enigmatic.

Our research aims to uncover the principles of PQC in mitochondria. We focus on proteins encoded by mitochondrial DNA and use cutting-edge biochemical methods for spatiotemporal analysis of the underlying mechanisms. Using the yeast Saccharomyces cerevisiae and human cells, we study these processes in young vs. aged cells to understand how mitochondrial PQC works in healthy cells, how these processes change with age, and identify points of onset for age-related diseases. Our goal is to expand the knowledge on mitochondrial PQC and pave the way for potential future treatments against human diseases.

For more information about the lab and our research visit:


Nature Communications, Springer Nature 2024, Vol. 15, (1)
Kohler, Verena; Kohler, Andreas; Berglund, Lisa Larsson; et al.
The Mitoribosome: Methods and Protocols, Humana Press 2023 : 119-132
Aufschnaiter, Andreas; Carlström, Andreas; Ott, Martin
EMBO Reports
Kohler, Andreas; Barrientos, Antoni; Fontanesi, Flavia; et al.
Molecular Cell, Cell Press 2023, Vol. 83, (19) : 3470-3484
Kohler, Andreas; Carlström, Andreas; Nolte, Hendrik; et al.
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2023, Vol. 16
Kohler, Verena; Braun, Ralf J.; Kohler, Andreas
BIOspektrum, Springer Nature 2022, Vol. 28, (4) : 366-369
Aufschnaiter, Andreas; Ott, Martin
Bioinformatics, Oxford University Press 2022, Vol. 38, (21) : 4908-4918
Dickinson, Quinn; Kohler, Andreas; Ott, Martin; et al.
Molecular Biology of the Cell, American Society for Cell Biology (ASCB) 2022, Vol. 33, (14)
Saini, Pawan Kumar; Dawitz, Hannah; Kohler, Andreas; et al.
Cells, MDPI 2021, Vol. 10, (11)
Ebrahimi, Mahsa; Habernig, Lukas; Broeskamp, Filomena; et al.
PLOS Genetics, Public Library of Science (PLoS) 2021, Vol. 17, (11)
Habernig, Lukas; Broeskamp, Filomena; Aufschnaiter, Andreas; et al.
EMBO Reports, John Wiley & Sons 2020, Vol. 21, (12)
Berndtsson, Jens; Kohler, Andreas; Rathore, Sorbhi; et al.
Genetics, neurology, behavior, and diet in parkinson's disease: The neuroscience of parkinson's, volume 2, Academic Press 2020 : 123-138
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Toxins, MDPI 2020, Vol. 12, (2)
Kohler, Andreas; Kohler, Verena; Khalifa, Shaden; et al.
Cells, MDPI 2020, Vol. 9, (5) : 1184-1184
Kohler, Verena; Kohler, Andreas; Büttner, Sabrina
Molecular Cell, Elsevier 2020, Vol. 79, (6) : 1051-1065.e10
Singh, Abeer Prakash; Salvatori, Roger; Aftab, Wasim; et al.
Cell Death and Disease, Springer Nature 2020, Vol. 11, (9)
Toth, Alexandra; Aufschnaiter, Andreas; Fedotovskaya, Olga; et al.
Journal of Biological Chemistry, Elsevier 2019, Vol. 294, (32) : 12020-12039
Gross, Angelina S.; Zimmermann, Andreas; Pendl, Tobias; et al.
Biochimica et Biophysica Acta. Molecular Cell Research, Elsevier 2019, Vol. 1866, (5) : 957-970
Kohler, Andreas; Büttner, Sabrina
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2018, Vol. 11
Kohler, Andreas; Kohler, Verena; Walter, Corvin; et al.
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (17) : 9201-9219
Kohler, Verena; Goessweiner-Mohr, Nikolaus; Kohler, Andreas; et al.
Microbial Cell, Shared Science Publishers OG 2018, Vol. 5, (4) : 212-214
Leibiger, Christine; Deisel, Jana; Aufschnaiter, Andreas; et al.
Human Molecular Genetics, Oxford University Press 2018, Vol. 27, (9) : 1593-1607
Leibiger, Christine; Deisel, Jana; Aufschnaiter, Andreas; et al.
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2017, Vol. 10
Kohler, Andreas; Habernig, Lukas; Kohler, Verena; et al.
Neural Regeneration Research, Wolters Kluwer 2017, Vol. 12, (11) : 1776-1776
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Cell and Tissue Research, Springer 2016, Vol. 367, (1) : 125-140
Kohler, Andreas; Kohler, Verena; Diessl, Jutta; et al.
Cell Cycle, Taylor & Francis 2015, Vol. 14, (15) : 2389-2390
Aufschnaiter, Andreas; Büttner, Sabrina

Research groups

Head of research
Andreas Kohler Lab