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Staff photo Andrei Chabes

Andrei Chabes

dNTPs and maintenance of genome stability

Contact

Works at

Affiliation
Professor at Department of Medical Biochemistry and Biophysics Role: Directory Co-ordinator, Head of department
Location
KBC building, H6, Campus, Umeå, A6-42-21 Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as professor at Molecular Infection Medicine Sweden (MIMS)
Location
Medicinsk kemi och biofysik, 90187 Umeå

dNTPs and maintenance of genome stability

The four dNTPs (dATP, dTTP, dCTP, and dGTP) are the building blocks of DNA. A balanced supply and a correct overall concentration of dNTPs are key prerequisites for faithful genome replication. These requirements, along with the fact that the concentrations of dNTPs fluctuate during the cell cycle, mean that the production of dNTPs must be tightly regulated through multiple mechanisms.

We are investigating (i) how the genome integrity checkpoint regulates the concentration of dNTPs and how dNTPs regulate the activation of the genome integrity checkpoint, and (ii) how imbalanced dNTP pools affect the fidelity of replication and genome stability and how different replication errors are recognized and repaired. We hope to understand how metabolic changes in the dNTP pool balance affect aging, the development of cancer, and other genetic disorders.

Our latest publications:

Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR and Chabes A (2020) Elimination of rNMPs from mitochondrial DNA has no effect on its stability. PNAS 117:14306-14313  

Sushma S, Koolmeister C, Tran P, Nilsson AK, Larsson NG and Chabes A (2020) Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos. Nature Metabolism  doi.org/10.1038/s42255-020-0264-z

All publications in PubMed (by date) and in Google Scholar (by citations).

2020
Nucleic Acids Research, Oxford Academic 2020, Vol. 48, (8) : 4274-4297
Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; et al.
2020
Cell reports, Elsevier 2020, Vol. 31, (6)
Davenne, Tamara; Klintman, Jenny; Sharma, Sushma; et al.
2020
Molecular Cell, Elsevier 2020, Vol. 78, (3) : 496-410.e4
Forey, Romain; Poveda, Ana; Sharma, Sushma; et al.
2020
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
2020
Nature metabolism, Nature Publishing Group 2020, Vol. 2, (8) : 673-675
Sharma, Sushma; Koolmeister, Camilla; Tran, Phong; et al.
2020
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313
Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.
2019
FEBS Open Bio, WILEY 2019, Vol. 9 : 21-21
Chabes, Andrei
2019
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (8) : 3986-3995
Garbacz, Marta A.; Cox, Phillip B.; Sharma, Sushma; et al.
2019
Molecular Cell, Elsevier 2019, Vol. 76, (5) : 784-+
Nicholls, Thomas J.; Spåhr, Henrik; Jiang, Shan; et al.
2019
PLoS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
2019
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (1) : 237-252
Schmidt, Tobias T.; Sharma, Sushma; Reyes, Gloria X.; et al.
2019
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
2019
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
2019
Nature Communications, Nature Publishing Group 2019, Vol. 10
Xing, Xuanxuan; Kane, Daniel P.; Bulock, Chelsea R.; et al.
2018
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (21)
Bacal, Julien; Moriel-Carretero, María; Pardo, Benjamin; et al.
2018
Nature, Vol. 557, (7703) : 57-61
Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; et al.
2018
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (11)
Kong, Ziqing; Jia, Shaodong; Chabes, Anna Lena; et al.
2018
Genes & Development, Vol. 32, (11-12) : 822-835
Lanz, Michael Charles; Oberly, Susannah; Sanford, Ethan James; et al.
2018
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (17)
Li, Shuqi; Xu, Zhiyun; Xu, Jiawei; et al.
2018
PLoS Genetics, PUBLIC LIBRARY SCIENCE 2018, Vol. 14, (1)
Peng, Xiao P.; Lim, Shelly; Li, Shibai; et al.
2018
G3: Genes, Genomes, Genetics, Vol. 8, (8) : 2551-2558
van Mourik, Paula M; de Jong, Jannie; Sharma, Sushma; et al.
2018
Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
2017
Molecular Cell, Elsevier 2017, Vol. 68, (2) : 446-455
Gan, Haiyun; Yu, Chuanhe; Devbhandari, Sujan; et al.
2017
Oncogene, Macmillan Publishers Ltd. 2017, Vol. 36, (42) : 5808-5818
Garzón, J.; Rodríguez, R.; Kong, Ziqing; et al.
2017
Nucleic Acids Research, Vol. 45, (3) : 1200-1218
Kochenova, Olga V; Bezalel-Buch, Rachel; Tran, Phong; et al.
2017
PLoS Genetics, Vol. 13, (10)
Maicher, André; Gazy, Inbal; Sharma, Sushma; et al.
2017
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
2017
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : E4442-E4451
Schmidt, Tobias T; Reyes, Gloria; Gries, Kerstin; et al.
2017
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
2016
Nucleic Acids Research, Vol. 44, (9) : 4222-4232
Kenigsberg, Ephraim; Yehuda, Yishai; Marjavaara, Lisette; et al.
2016
Cell reports, Vol. 17, (6) : 1657-1670
Liew, Li Phing; Lim, Zun Yi; Cohen, Matan; et al.
2016
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (17) : 4723-4728
Rentoft, Matilda; Lindell, Kristoffer; Tran, Phong; et al.
2016
Nucleic Acids Research, Vol. 44, (4) : 1669-1680
Watt, Danielle L.; Buckland, Robert J.; Lujan, Scott A.; et al.
2015
OncoTarget, Vol. 6, (14) : 12587-12602
Barfeld, Stefan J; Fazli, Ladan; Persson, Margareta; et al.
2015
Yeast, Wiley-Blackwell 2015, Vol. 32, (Suppl. 1) : S56-S56
Earp, Caroline; Rowbotham, Samuel; Marjavaara, Lisette; et al.
2015
Biology open, Vol. 4, (12) : 1739-1743
Earp, Caroline; Rowbotham, Samuel; Merényi, Gábor; et al.
2015
DNA Replikation: Methods and Protocols, New York: Springer-Verlag New York 2015 : 113-121
Jia, Shaodong; Marjavaara, Lisette; Buckland, Robert; et al.
2015
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2467-E2476
Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; et al.
2015
Nature Structural & Molecular Biology, Vol. 22, (4) : 291-U35
Williams, Jessica S; Clausen, Anders R; Lujan, Scott A; et al.
2015
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2457-E2466
Williams, Lindsey N; Marjavaara, Lisette; Knowels, Gary M; et al.
2014
PLOS Genetics, Vol. 10, (12)
Buckland, Robert J; Watt, Danielle L; Chittoor, Balasubramanyam; et al.
2014
Scientific Reports, Macmillan Publishers Ltd. 2014, Vol. 4 : 5539-
Domkin, Vladimir; Chabes, Andrei
2014
PLOS Genetics, Public library science 2014, Vol. 10, (10) : e1004667-
Lin, Chia-Yeh; Wu, Meng-Ying; Gay, Sophie; et al.
2014
Nucleic Acids Research, Oxford University Press 2014, Vol. 42, (10) : 6314-6325
Rubinstein, Linda; Ungar, Lior; Harari, Yaniv; et al.
2014
Molecular Cell, Vol. 54, (4) : 691-697
Yoshida, Kazumasa; Bacal, Julien; Desmarais, Damien; et al.
2014
Molecular Cell, Vol. 56, (4) : 551-563
Yu, Chuanhe; Gan, Haiyun; Han, Junhong; et al.
2013
Genetics, The Genetics Society 2013, Vol. 193, (4) : 1095-1105
Gupta, Amitabha; Sharma, Sushma; Reichenbach, Patrick; et al.
2013
Molecular and Cellular Biology, Vol. 33, (16) : 3202-3213
Hoch, Nicolas C; Chen, Eric S-W; Buckland, Robert; et al.
2013
Nucleic Acids Research, Oxford University Press 2013, Vol. 41, (22) : 10371-10378
Tsaponina, Olga; Chabes, Andrei
2013
Molecular Cell, Cell Press 2013, Vol. 49, (5) : 1010-1015
Williams, Jessica S.; Smith, Dana J.; Marjavaara, Lisette; et al.

Research groups

Head of research
Andrei Chabes