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Clas Ahlm

We study disease mechanisms in the Puumala virus infection and COVID-19, in order to understand disease mechanisms and be able to develop future treatment.

Contact

clas.ahlm@umu.se

+46 90 785 23 09

Works at

Professor, senior consultant (attending) physician at Department of Clinical Microbiology Units: Infectious Diseases, Section of Infection and Immunology

Infektion by 24 (K) Köksvägen, Universitetssjukhuset, 3173 Umeå universitet, 901 85 Umeå

Clas Ahlm studies two important viral infections, COVID-19 and hantavirus infection. Both viral infections are transmitted via the lungs and can cause severe illness and even death, especially in the elderly and people with other concomitant chronic diseases.

Further knowledge is needed about both disease mechanisms and protective immunity, effective treatment and vaccine efficacy for COVID-19, and there is still a lack of treatment and vaccine against Puumala virus infection and other more serious viruses within the hantavirus group.

High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19

Frontiers In Public Health, Frontiers Media S.A. 2023, Vol. 11

Ahmad, Irma; Edin, Alicia; Granvik, Christoffer; et al.

Risk factors for impaired respiratory function post COVID-19: a prospective cohort study of nonhospitalized and hospitalized patients

Journal of Internal Medicine

Björsell, Tove; Sundh, Josefin; Lange, Anna; et al.

Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya

Malaria Journal, BioMed Central (BMC) 2023, Vol. 22, (1)

Hollowell, Thomas; Sewe, Maquins Odhiambo; Rocklöv, Joacim; et al.

WCN23-0624 acute kidney injury and covid-19

Kidney International Reports, Supplements, Elsevier 2023, Vol. 8, (3) : S438-S438

Jerndal, Hanna; Stegmayr, Bernd; Normark, J.; et al.

Characterizing movement patterns of nomadic pastoralists and their exposure to rift valley fever in Kenya

The international archives of the photogrammetry, remote sensing and spatial information sciences, Copernicus GmbH 2023 : 211-216

Mosomtai, G.; Kasiiti, J.L.; Murithi, R.M.; et al.

Vector competence of Anopheles stephensi for O'nyong-nyong virus: a risk for global virus spread

Parasites & Vectors, BioMed Central (BMC) 2023, Vol. 16, (1)

Mutsaers, Maud; Engdahl, Cecilia; Wilkman, Lukas; et al.

Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study

The Lancet Regional Health: Europe

Vikström, Linnea; Fjällström, Peter; Gwon, Yong-Dae; et al.

At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study

Eurosurveillance, European Centre for Disease Control and Prevention (ECDC) 2023, Vol. 28, (13)

Wigren, Julia; Vikström, Linnea; Rosendal, Ebba; et al.

Mosquito-borne viruses causing human disease in Fennoscandia - Past, current, and future perspectives

Frontiers in Medicine, Frontiers Media S.A. 2023, Vol. 10

Wilkman, Lukas; Ahlm, Clas; Evander, Magnus; et al.

Human herpes virus type-6 is associated with central nervous system infections in children in Sudan

African Journal of Laboratory Medicine, AOSIS 2022, Vol. 11, (1)

Abdelrahim, Nada A.; Mohamed, Nahla; Evander, Magnus; et al.

Viral meningitis in Sudanese children: differentiation, etiology and review of literature

Medicine, Lippincott Williams & Wilkins 2022, Vol. 101, (46)

Abdelrahim, Nada Abdelghani; Mohamed, Nahla; Evander, Magnus; et al.

Structural Modifications and Biological Evaluations of Rift Valley Fever Virus Inhibitors Identified from Chemical Library Screening

ACS Omega, American Chemical Society (ACS) 2022, Vol. 7, (8) : 6854-6868

Islam, Koushikul; Carlsson, Marcus; Enquist, Per-Anders; et al.

Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection

Science immunology, American Association for the Advancement of Science 2022, Vol. 7, (73)

Kaku, Chengzi I.; Bergeron, Alan J.; Ahlm, Clas; et al.

Broad anti–SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination

Science, American Association for the Advancement of Science 2022, Vol. 375, (6584) : 1041-1047

Kaku, Chengzi I.; Champney, Elizabeth R.; Normark, Johan; et al.

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Science Translational Medicine, American Association for the Advancement of Science 2022, Vol. 14, (636)

Mittler, Eva; Wec, Anna Z.; Tynell, Janne; et al.

Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

Frontiers in Immunology, Frontiers Media S.A. 2022, Vol. 13

Schagatay, Felix; Diamant, Klara; Lidén, Mats; et al.

Inkoo and Sindbis viruses in blood sucking insects, and a serological study for Inkoo virus in semi-domesticated Eurasian tundra reindeer in Norway

Virology Journal, Springer Nature 2022, Vol. 19, (1)

Shakya, Ruchika; Tryland, Morten; Vikse, Rose; et al.

Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies

Infectious Diseases, Vol. 54, (10) : 766-772

Tuiskunen-Bäck, Anne; Rasmuson, Johan; Thunberg, Therese; et al.

Reply to Carlos G. Wambier and Gerard J. Nau's Letter to the Editor re: Karin Welén, Ebba Rosendal, Magnus Gisslén, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. 2022;81:285–93. Positive Effects of Enzalutamide for Hospitalized COVID-19 Patients: Still No Positive Effect of Enzalutamide for Hospitalized COVID-19 Patients

European Urology, Elsevier 2022, Vol. 81, (6) : e143-e144

Welén, Karin; Rosendal, Ebba; Freyhult, Eva; et al.

A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data

European Urology, Elsevier 2022, Vol. 81, (3) : 285-293

Welén, Karin; Rosendal, Ebba; Gisslén, Magnus; et al.

Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts

mSphere, American Society for Microbiology 2021, Vol. 6, (2)

Bortz, Robert H.; Florez, Catalina; Laudermilch, Ethan; et al.

Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

JCI Insight, American Society for Clinical Investigation 2021, Vol. 6, (22)

Cagigi, Alberto; Yu, Meng; Österberg, Björn; et al.

Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis

Frontiers in Immunology, Frontiers Media S.A. 2021, Vol. 11

Dernstedt, Andy; Leidig, Jana; Holm, Anna; et al.

Generation of plasma cells and CD27^-IgD^- B cells during hantavirus infection is associated with distinct pathological findings

Clinical & Translational Immunology (CTI), John Wiley & Sons 2021, Vol. 10

Kerkman, Priscilla; Dernstedt, Andy; Tadala, Lalitha; et al.

MAIT cell activation is associated with disease severity markers in acute hantavirus infection

Cell Reports Medicine, Saunders Elsevier 2021, Vol. 2, (3)

Maleki, Kimia T.; Tauriainen, Johanna; García, Marina; et al.

Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination

New England Journal of Medicine, Massachusetts Medical Society 2021, Vol. 385, (11) : 1049-1051

Normark, Johan; Vikström, Linnea; Yong-Dae, Gwon; et al.

Emerging Mosquito-Borne Viruses Linked to Aedes aegypti and Aedes albopictus: Global Status and Preventive Strategies

Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2021, Vol. 21, (10) : 731-746

Näslund, Jonas; Ahlm, Clas; Islam, Md. Koushikul; et al.

Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya

Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2021, Vol. 21, (10) : 809-816

Obanda, Vincent; Agwanda, Bernard; Blanco-Penedo, Isabel; et al.

COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial

Trials, BioMed Central 2021, Vol. 22, (1)

Welén, Karin; Överby, Anna K.; Ahlm, Clas; et al.

Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex encephalitis

Clinical Microbiology and Infection, Elsevier 2021, Vol. 27, (8) : 1131-1136

Westman, Gabriel; Aurelius, Elisabeth; Ahlm, Clas; et al.

Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome

Pathogens, MDPI 2020, Vol. 9, (8)

Hansson, Magnus; Gustafsson, Rasmus; Jacquet, Chloé; et al.

Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?

Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology (ASBMB) 2020, Vol. 295, (45) : 15418-15422

Hellman, Urban; Karlsson, Mats G.; Engström-Laurent, Anna; et al.

Seewis hantavirus in common shrew (Sorex araneus) in Sweden

Virology Journal, BioMed Central 2020, Vol. 17, (1)

Lwande, Olivia Wesula; Mohamed, Nahla; Bucht, Göran; et al.

Globe-Trotting Aedes aegypti and Aedes albopictus: Risk Factors for Arbovirus Pandemics

Vector Borne and Zoonotic Diseases, Vol. 20, (2) : 71-81

Lwande, Olivia Wesula; Obanda, Vincent; Lindstrom, Anders; et al.

Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells

Journal of Virology, American Society for Microbiology 2020, Vol. 94, (14)

Persson, David; Lenman, Annasara; Frängsmyr, Lars; et al.

Circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation

Journal of Infectious Diseases, Oxford University Press 2020, Vol. 222, (8) : 1392-1399

Schmedes, Clare M.; Grover, Steven P.; Hisada, Yohei M.; et al.

High risk for human exposure to Rift Valley fever virus in communities living along livestock movement routes: A cross-sectional survey in Kenya

PLoS Neglected Tropical Diseases, San Francisco: Public Library of Science 2020, Vol. 14, (2)

Tigoi, Caroline; Sang, Rosemary; Chepkorir, Edith; et al.

Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine

Proceedings of the National Academy of Sciences of the United States of America, Washington: National Academy of Science 2020, Vol. 117, (12) : 6675-6685

Wec, Anna Z.; Haslwanter, Denise; Abdiche, Yasmina N.; et al.

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes

Journal of Internal Medicine, John Wiley & Sons 2019, Vol. 285, (5) : 510-523

Klingstrom, J.; Smed-Sörensen, A.; Maleki, K. T.; et al.

Experimental Infection and Transmission Competence of Sindbis Virus in Culex torrentium and Culex pipiens Mosquitoes from Northern Sweden

Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2019, Vol. 19, (2) : 128-133

Lwande, Olivia Wesula; Näslund, Jonas; Lundmark, Eva; et al.

Haploinsufficiency of UNC13D increases the risk of lymphoma

Cancer, John Wiley & Sons 2019, Vol. 125, (11) : 1848-1854

Löfstedt, Alexandra; Ahlm, Clas; Tesi, Bianca; et al.

MMP9 Associates with Endothelial Glycocalyx Degradation During Haemorrhagic Fever with Renal Syndrome

Journal of Vascular Research, S. Karger 2019, Vol. 56 : 35-35