Umeå universitet
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Personalbild Clas Ahlm

Clas Ahlm

Vi studerar sjukdomsmekanismer vid virusinfektionerna sorkfeber och Covid-19, för att förstå sjukdomsmekanismer och kunna utveckla framtida behandling.

Kontakt

E-post
clas.ahlm@umu.se
Telefon
090-785 23 09

Verksam vid

Anknytning
Professor, överläkare vid Institutionen för klinisk mikrobiologi Enhet: Infektionssjukdomar, Avdelningen för infektion och immunologi
Plats
Infektion by 24 (K) Köksvägen, Universitetssjukhuset, 3173 Umeå universitet, 901 85 Umeå

Clas Ahlm studerar två viktiga virusinfektioner, COVID-19 och hantavirus infektion. Båda virusinfektionerna smittar via lungorna och kan orsaka svår sjukdom och till och med död framför allt hos äldre och personer med annan samtidig kronisk sjukdom. Ytterligare kunskap behövs om både sjukdomsmekanismer och skyddande immunitet, effektiv behandling och vaccineffekt för Covid-19, och det saknas ännu behandling och vaccin mot sorkfeber och andra allvarligare virus inom gruppen hantavirus.

Structural Modifications and Biological Evaluations of Rift Valley Fever Virus Inhibitors Identified from Chemical Library Screening
ACS Omega, American Chemical Society (ACS) 2022, Vol. 7, (8) : 6854-6868
Islam, Koushikul; Carlsson, Marcus; Enquist, Per-Anders; et al.
Broad anti–SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination
Science, American Association for the Advancement of Science 2022, Vol. 375, (6584) : 1041-1047
Kaku, Chengzi I.; Champney, Elizabeth R.; Normark, Johan; et al.
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
Science Translational Medicine, American Association for the Advancement of Science 2022, Vol. 14, (636)
Mittler, Eva; Wec, Anna Z.; Tynell, Janne; et al.
Reply to Carlos G. Wambier and Gerard J. Nau's Letter to the Editor re: Karin Welén, Ebba Rosendal, Magnus Gisslén, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. 2022;81:285–93. Positive Effects of Enzalutamide for Hospitalized COVID-19 Patients: Still No Positive Effect of Enzalutamide for Hospitalized COVID-19 Patients
European Urology, Elsevier 2022, Vol. 81, (6) : e143-e144
Welén, Karin; Rosendal, Ebba; Freyhult, Eva; et al.
A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data
European Urology, Elsevier 2022, Vol. 81, (3) : 285-293
Welén, Karin; Rosendal, Ebba; Gisslén, Magnus; et al.
Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts
mSphere, American Society for Microbiology 2021, Vol. 6, (2)
Bortz, Robert H.; Florez, Catalina; Laudermilch, Ethan; et al.
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination
JCI Insight, American Society for Clinical Investigation 2021, Vol. 6, (22)
Cagigi, Alberto; Yu, Meng; Österberg, Björn; et al.
Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis
Frontiers in Immunology, Frontiers Media S.A. 2021, Vol. 11
Dernstedt, Andy; Leidig, Jana; Holm, Anna; et al.
Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings
Clinical & Translational Immunology, John Wiley & Sons 2021, Vol. 10
Kerkman, Priscilla; Dernstedt, Andy; Tadala, Lalitha; et al.
MAIT cell activation is associated with disease severity markers in acute hantavirus infection
Cell Reports Medicine, Saunders Elsevier 2021, Vol. 2, (3)
Maleki, Kimia T.; Tauriainen, Johanna; García, Marina; et al.
Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination
New England Journal of Medicine, Massachusetts Medical Society 2021, Vol. 385, (11) : 1049-1051
Normark, Johan; Vikström, Linnea; Yong-Dae, Gwon; et al.
Emerging Mosquito-Borne Viruses Linked to Aedes aegypti and Aedes albopictus: Global Status and Preventive Strategies
Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2021, Vol. 21, (10) : 731-746
Näslund, Jonas; Ahlm, Clas; Islam, Md. Koushikul; et al.
Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya
Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2021, Vol. 21, (10) : 809-816
Obanda, Vincent; Agwanda, Bernard; Blanco-Penedo, Isabel; et al.
COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial
Trials, BioMed Central 2021, Vol. 22, (1)
Welén, Karin; Överby, Anna K.; Ahlm, Clas; et al.
Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex encephalitis
Clinical Microbiology and Infection, Elsevier 2021, Vol. 27, (8) : 1131-1136
Westman, Gabriel; Aurelius, Elisabeth; Ahlm, Clas; et al.
Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome
Pathogens, MDPI 2020, Vol. 9, (8)
Hansson, Magnus; Gustafsson, Rasmus; Jacquet, Chloé; et al.
Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?
Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology (ASBMB) 2020, Vol. 295, (45) : 15418-15422
Hellman, Urban; Karlsson, Mats G.; Engström-Laurent, Anna; et al.
Seewis hantavirus in common shrew (Sorex araneus) in Sweden
Virology Journal, BioMed Central 2020, Vol. 17, (1)
Lwande, Olivia Wesula; Mohamed, Nahla; Bucht, Göran; et al.
Globe-Trotting Aedes aegypti and Aedes albopictus: Risk Factors for Arbovirus Pandemics
Vector Borne and Zoonotic Diseases, Vol. 20, (2) : 71-81
Lwande, Olivia Wesula; Obanda, Vincent; Lindstrom, Anders; et al.
Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells
Journal of Virology, American Society for Microbiology 2020, Vol. 94, (14)
Persson, David; Lenman, Annasara; Frängsmyr, Lars; et al.
Circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation
Journal of Infectious Diseases, Oxford University Press 2020, Vol. 222, (8) : 1392-1399
Schmedes, Clare M.; Grover, Steven P.; Hisada, Yohei M.; et al.
High risk for human exposure to Rift Valley fever virus in communities living along livestock movement routes: A cross-sectional survey in Kenya
PLoS Neglected Tropical Diseases, San Francisco: Public Library of Science 2020, Vol. 14, (2)
Tigoi, Caroline; Sang, Rosemary; Chepkorir, Edith; et al.
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine
Proceedings of the National Academy of Sciences of the United States of America, Washington: National Academy of Science 2020, Vol. 117, (12) : 6675-6685
Wec, Anna Z.; Haslwanter, Denise; Abdiche, Yasmina N.; et al.
Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes
Journal of Internal Medicine, John Wiley & Sons 2019, Vol. 285, (5) : 510-523
Klingstrom, J.; Smed-Sörensen, A.; Maleki, K. T.; et al.
Experimental Infection and Transmission Competence of Sindbis Virus in Culex torrentium and Culex pipiens Mosquitoes from Northern Sweden
Vector Borne and Zoonotic Diseases, Mary Ann Liebert 2019, Vol. 19, (2) : 128-133
Lwande, Olivia Wesula; Näslund, Jonas; Lundmark, Eva; et al.
Haploinsufficiency of UNC13D increases the risk of lymphoma
Cancer, John Wiley & Sons 2019, Vol. 125, (11) : 1848-1854
Löfstedt, Alexandra; Ahlm, Clas; Tesi, Bianca; et al.
MMP9 Associates with Endothelial Glycocalyx Degradation During Haemorrhagic Fever with Renal Syndrome
Journal of Vascular Research, S. Karger 2019, Vol. 56 : 35-35
Rankin, Gregory; Byström, Julia Wigren; Gustafsson, Rasmus; et al.
Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
Cell reports, Cell Press 2019, Vol. 28, (8) : 2124-2139
Sola-Riera, Caries; Gupta, Shawon; Maleki, Kimia T.; et al.
Quantification and kinetics of viral RNA transcripts produced in Orthohantavirus infected cells
Virology Journal, BIOMED CENTRAL LTD 2018, Vol. 15 : 1-7
Bystrom, Julia Wigren; Näslund, Jonas; Trulsson, Fredrik; et al.
Mesenteric Vein Thrombosis Following Platelet Transfusion in a Patient with Hemorrhagic Fever with Renal Syndrome: A Case Report
TH open : companion journal to thrombosis and haemostasis, Georg Thieme Verlag KG 2018, Vol. 2, (3) : e261-e264
Connolly-Andersen, Anne-Marie; Rasmuson, Johan; Öman, Mikael; et al.
Risk of venous thromboembolism following hemorrhagic fever with renal syndrome: a self-controlled case series study
Clinical Infectious Diseases, Oxford University Press 2018, Vol. 66, (2) : 268-273
Connolly-Andersen, Anne-Marie; Whitaker, Heather; Klingstrom, Jonas; et al.
Mosquitoborne Sindbis Virus Infection and Long-Term Illness
Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC) 2018, Vol. 24, (6) : 1141-1142
Gylfe, Åsa; Ribers, Åsa; Forsman, Oscar; et al.
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
Scientific Reports, NATURE PUBLISHING GROUP 2018, Vol. 8
Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; et al.
Datasets for mapping pastoralist movement patterns and risk zones of Rift Valley fever occurrence
Data in Brief, Elsevier 2018, Vol. 16 : 762-770
Mosomtai, Gladys; Evander, Magnus; Mundia, Charles; et al.
Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients
Frontiers in Immunology, Frontiers Media S.A. 2018, Vol. 9
Thunström Salzer, Anna; Niemiec, Maria Joanna; Hosseinzadeh, Ava; et al.
Clinical significance of IgM and IgA class anti-NMDAR antibodies in herpes simplex encephalitis
Journal of Clinical Virology, Elsevier 2018, Vol. 103 : 75-80
Westman, Gabriel; Sohrabian, Azita; Aurelius, Elisabeth; et al.
Ethnic groups' knowledge, attitude and practices and Rift Valley fever exposure in Isiolo County of Kenya
PLoS Neglected Tropical Diseases, Vol. 11, (3)
Affognon, Hippolyte; Mburu, Peter; Hassan, Osama Ahmed; et al.
Human lung dendritic cells: spatial distribution and phenotypic identification in endobronchial biopsies using immunohistochemistry and flow cytometry
Jove-journal pf visualized experiments, Cambridge: MyJoVE Corp. 2017, (119)
Baharom, Faezzah; Rankin, Gregory; Scholz, Saskia; et al.
The One Health approach to identify knowledge, attitudes and practices that affect community involvement in the control of Rift Valley fever outbreaks
PLoS Neglected Tropical Diseases, Vol. 11, (2)
Hassan, Osama Ahmed; Affognon, Hippolyte; Rocklöv, Joacim; et al.
The B cell response towards Puumala virus infection: can B cells be infected?
Scandinavian Journal of Immunology, John Wiley & Sons 2017, Vol. 86, (4) : 260-260
Kerkman, Priscilla; Tuiskunen-Bäck, Anne; Dernstedt, Andy; et al.
Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing
Virology Journal, Vol. 14
Lwande, Olivia Wesula; Bucht, Goran; Ahlm, Clas; et al.
Circulation and diagnostics of Puumala virus in Norway: nephropatia epidemica incidence and rodent population dynamics
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), Vol. 125, (8) : 732-742
Milhano, Natacha; Korslund, Lars; Evander, Magnus; et al.
Distribution and abundance of key vectors of Rift Valley fever and other arboviruses in two ecologically distinct counties in Kenya
PLoS Neglected Tropical Diseases, PUBLIC LIBRARY SCIENCE 2017, Vol. 11, (2)
Sang, Rosemary; Arum, Samwel; Chepkorir, Edith; et al.
Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
PLoS Pathogens, Public library science 2017, Vol. 13, (6)
Scholz, Saskia; Baharom, Faezzah; Rankin, Gregory; et al.
Remotely sensed environmental conditions and malaria mortality in three malaria endemic regions in western Kenya
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene 2017, Vol. 95, (5) : 119-119
Sewe, Maquins O.; Ahlm, Clas; Rocklöv, Joacim
Forecasting malaria admissions at a rural district hospital in Western Kenya using remote sensing data
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene 2017, Vol. 95, (5) : 304-304
Sewe, Maquins O.; Tozan, Yesim; Rocklöv, Joacim; et al.
A methodological framework for economic evaluation of operational response to vector-borne disease forecasts
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene 2017, Vol. 97, (5) : 436-437
Sewe, Maquins Odhiambo; Tozan, Yesim; Ahlm, Clas; et al.
Using remote sensing environmental data to forecast malaria incidence at a rural district hospital in Western Kenya
Scientific Reports, NATURE PUBLISHING GROUP 2017, Vol. 7
Sewe, Maquins Odhiambo; Tozan, Yesim; Ahlm, Clas; et al.
Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology
Open Forum Infectious Diseases, Oxford University Press 2017, Vol. 4, (4)
Sironen, Tarja; Sane, Jussi; Lokki, Marja-Liisa; et al.
Inverse expression of the inhibitory/activating receptors TIGIT/CD226 on CD8 T cells in acute HFRS
Scandinavian Journal of Immunology, John Wiley & Sons 2017, Vol. 86, (4) : 291-291
Tauriainen, Johanna; Maleki, Kimia; Blom, Kim; et al.
Visa publikationer i DiVA
Forskning på ett ögonblick med Clas Ahlm

Clas Ahlm forskar på sorkfeber, en sjukdom han kallar för "Norrlands svar på Ebola". (Video, 1:02 min, 2016)