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Staff photo Francesca Aguilo

Francesca Aguilo

My research is about RNA-based gene regulation of cell fate and breast cancer.

Research qualifications: Docent

Contact

E-mail
francesca.aguilo@umu.se
Phone

Works as

Affiliation
Associate professor at Department of Molecular Biology Section: Group Francesca Aguilo
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

The goal of our current research is to decipher novel epigenetic and RNA-based  mechanisms affecting global gene expression i.e., the process by which the information from a gene is used in the synthesis of a functional gene product, and their implication in cell fate and cancer initiation and progression.

News SciLifeLab
New zinc finger-containing proteins vital for embryonic stem cell maintenance

More about the research
New finding on pluripotency for embryonic stem cell

International staff interview
International Story by Francesca Aguilo

Editorial: translational control in cancer
NAR Cancer, Oxford University Press 2024, Vol. 6, (3)
Aguilo, Francesca; Dassi, Erik
METTL3 as a master regulator of translation in cancer: mechanisms and implications
NAR Cancer, Oxford University Press 2024, Vol. 6, (1)
Esteva-Socias, Margalida; Aguilo, Francesca
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Malla, Sandhya; Kumari, Kanchan; García-Prieto, Carlos A.; et al.
Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells
Scientific Reports, Nature Publishing Group 2024, Vol. 14, (1)
Malla, Sandhya; Martinez Gamero, Carlos; Kumari, Kanchan; et al.
METTL3 regulates breast cancer-associated alternative splicing switches
Oncogene, Nature Publishing Group 2023, Vol. 42 : 911-925
Achour, Cyrinne; Bhattarai, Devi Prasad; Groza, Paula; et al.
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Xu, An; Liu, Mo; Huang, Mo-Fan; et al.
m6A RNA immunoprecipitation followed by high-throughput sequencing to map N6-Methyladenosine
Post-transcriptional gene regulation, Humana Press 2022 : 355-362
Bhattarai, Devi Prasad; Aguilo, Francesca
MODOMICS: a database of RNA modification pathways. 2021 update
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (D1) : D231-D235
Boccaletto, Pietro; Stefaniak, Filip; Ray, Angana; et al.
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
EMBO Reports, John Wiley & Sons 2022, Vol. 23, (3)
Malla, Sandhya; Bhattarai, Devi Prasad; Groza, Paula; et al.
A mark of disease: How mRNA modifications shape genetic and acquired pathologies
RNA: A publication of the RNA Society, Cold Spring Harbor Laboratory Press (CSHL) 2021, Vol. 27, (4) : 367-389
Destefanis, Eliana; Avşar, Gülben; Groza, Paula; et al.
Regulatory roles of RNA modifications in breast cancer
NAR Cancer, Oxford University Press 2021, Vol. 3, (3)
Kumari, Kanchan; Groza, Paula; Aguilo, Francesca
LSD1: Expanding functions in stem cells and differentiation
Cells, MDPI 2021, Vol. 10, (11)
Martinez-Gamero, Carlos; Malla, Sandhya; Aguilo, Francesca
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Nature Communications, Nature Publishing Group 2021, Vol. 12, (1)
Relier, Sébastien; Ripoll, Julie; Guillorit, Hélène; et al.
Long Noncoding RNAs as Players in Breast Tumorigenesis
The chemical biology of long noncoding RNAs, Springer 2020 : 385-403
Achour, Cyrinne; Aguilo, Francesca
Steering pluripotency and differentiation with N6-methyladenosine RNA modification
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, Elsevier 2019, Vol. 1862, (3) : 394-402
Malla, Sandhya; Melguizo-Sanchis, Dario; Aguilo, Francesca
Long non-coding RNA and Polycomb: an intricate partnership in cancer biology
Frontiers in Bioscience, Vol. 23 : 2106-2132
Achour, Cyrinne; Aguilo, Francesca
The N6-Methyladenosine RNA modification in pluripotency and reprogramming
Current Opinion in Genetics and Development, Elsevier 2017, Vol. 46 : 77-82
Aguilo, Francesca; Walsh, Martin J.
THAP1: role in mouse embryonic stem cell survival and differentiation
Stem Cell Reports, Cell Press 2017, Vol. 9, (1) : 92-107
Aguilo, Francesca; Zakirova, Zuchra; Nolan, Katie; et al.
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
Nucleic Acids Research, Oxford University Press 2017, Vol. 45, (19) : 11106-11120
Rengasamy, Madhumitha; Zhang, Fan; Vashisht, Ajay; et al.
Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease
Long non-coding RNAs in human disease, Springer 2016 : 29-39
Aguilo, Francesca; Di Cecilia, Serena; Walsh, Martin J
Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α
Cell Reports, Vol. 14, (3) : 479-492
Aguilo, Francesca; Li, SiDe; Balasubramaniyan, Natarajan; et al.
RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells
Cancer Research, Vol. 76, (19) : 5615-5627
Di Cecilia, Serena; Zhang, Fan; Sancho, Ana; et al.
ZNF217/ZFP217 Meets Chromatin and RNA
Trends in Biochemical Sciences (TIBS), Elsevier 2016, Vol. 41, (12) : 986-988
Lee, Dung-Fang; Walsh, Martin J.; Aguiló, Francesca
Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7
ACS Medicinal Chemistry Letters, Vol. 7, (6) : 601-605
Ren, Chunyan; Smith, Steven G.; Yap, Kyoko; et al.
Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.
Cell Stem Cell, Vol. 17, (6) : 689-704
Aguilo, Francesca; Zhang, Fan; Sancho, Ana; et al.
CHD6 regulates the topological arrangement of the CFTR locus
Human Molecular Genetics, Vol. 24, (10) : 2724-2732
Sancho, Ana; Li, SiDe; Paul, Thankam; et al.
Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.
EMBO Journal, Vol. 32, (7)
Martin, Nadine; Popov, Nikolay; Aguilo, Francesca; et al.
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Cell Stem Cell, Vol. 11, (2)
Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; et al.
Prdm16 is a physiologic regulator of hematopoietic stem cells.
Blood, Vol. 117, (19)
Aguilo, Francesca; Avagyan, Serine; Labar, Amy; et al.
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.
Cancer Research, Vol. 71, (16)
Aguilo, Francesca; Zhou, Ming-Ming; Walsh, Martin J
Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis.
Blood, Vol. 118, (23)
Avagyan, Serine; Aguilo, Francesca; Kamezaki, Kenjiro; et al.
Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma.
Biochemical Journal, Vol. 427, (2)
Aguiló, Francesca; Camarero, Nuria; Relat, Joana; et al.
Fibrillarin regulates oncogenic protein pools and ribosome protein composition in triple-negative breast cancer
Groza, Paula; Kumari, Kanchan; Destefanis, Eliana; et al.
LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells
Malla, Sandhya; Kumari, Kanchan; Martinez Gamero, Carlos; et al.
The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells
Malla, Sandhya; Kumari, Kanchan; Martinez Gamero, Carlos; et al.
View publications in DiVA

Research groups

Head of research
Francesca Aguilo
Targeting cancer cells without affecting healthy cells

Francesca Aguilos work lies at the cutting edge of biomedical research and cancer.