Leszek Kleczkowski

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Affiliated as professor emeritus at Department of Plant Physiology Section: Umeå Plant Science Centre - UmU

KB. K4 (UPSC), Artedigränd 7, Fysiologisk botanik, UPSC, KB. F4 (B4.54.41) Umeå universitet, 901 87 Umeå

Research: Research in my group is focused on regulation of the formation of nucleotide-sugar precursors to polysaccharides (e.g. sucrose, cellulose) in plants. Particular emphasis is placed on elucidation of mechanisms of regulation of the proteins involved and those governing the operation of sugar-dependent signal transduction pathways.

for more detailed information, Leszek Kleczkowski@UPSC

Multiple roles of glycerate kinase—from photorespiration to gluconeogenesis, C4 metabolism, and plant immunity

International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (6)

Kleczkowski, Leszek A.; Igamberdiev, Abir U.

Exploring redox modulation of plant UDP-glucose pyrophosphorylase

International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (10)

Decker, Daniel; Aubert, Juliette; Wilczynska, Malgorzata; et al.

Toward understanding the emergence of life: a dual function of the system of nucleotides in the metabolically closed autopoietic organization

Biosystems (Amsterdam. Print), Elsevier 2023, Vol. 224

Igamberdiev, Abir U.; Kleczkowski, Leszek A.

Magnesium and cell energetics: at the junction of metabolism of adenylate and non-adenylate nucleotides

Journal of plant physiology (Print), Elsevier 2023, Vol. 280

Kleczkowski, Leszek A.; Igamberdiev, Abir U.

Effects of Magnesium, Pyrophosphate and Phosphonates on Pyrophosphorolytic Reaction of UDP-Glucose Pyrophosphorylase

PLANTS, MDPI 2022, Vol. 11, (12)

Kleczkowski, Leszek A.; Decker, Daniel

Pyrophosphate as an alternative energy currency in plants

Biochemical Journal, Portland Press 2021, Vol. 478, (8) : 1515-1524

Igamberdiev, Abir U.; Kleczkowski, Leszek A.

Magnesium signaling in plants

International Journal of Molecular Sciences, MPDI 2021, Vol. 22, (3)

Kleczkowski, Leszek A.; Igamberdiev, Abir U.

Optimization of nucleotide sugar supply for polysaccharide formation via thermodynamic buffering

Biochemical Journal, Portland Press 2020, Vol. 477, (2) : 341-356

Kleczkowski, Leszek A.; Igamberdiev, Abir U.

UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, Providing de novo Precursors for Glycosylation Reactions

Frontiers in Plant Science, Frontiers Media S.A. 2019, Vol. 9

Decker, Daniel; Kleczkowski, Leszek A.

Thermodynamic buffering, stable non-equilibrium and establishment of the computable structure of plant metabolism

Progress in Biophysics and Molecular Biology, PERGAMON-ELSEVIER SCIENCE LTD 2019, Vol. 146 : 23-36

Igamberdiev, Abir U.; Kleczkowski, Leszek A.

The structure-activity relationship of the salicylimide derived inhibitors of UDP-sugar producing pyrophosphorylases

Plant Signalling & Behavior, Taylor & Francis 2018, Vol. 13, (8)

Decker, Daniel; Öberg, Christopher; Kleczkowski, Leszek A.

The Glycerate and Phosphorylated Pathways of Serine Synthesis in Plants: The Branches of Plant Glycolysis Linking Carbon and Nitrogen Metabolism

Frontiers in Plant Science, Frontiers Media S.A. 2018, Vol. 9

Igamberdiev, Abir U.; Kleczkowski, Leszek A.

Substrate Specificity and Inhibitor Sensitivity of Plant UDP-Sugar Producing Pyrophosphorylases

Frontiers in Plant Science, FRONTIERS MEDIA SA 2017, Vol. 8

Decker, Daniel; Kleczkowski, Leszek

Identification and characterization of inhibitors of UDP-glucose and UDP-sugar pyrophosphorylases for in vivo studies

The Plant Journal, John Wiley & Sons 2017, Vol. 90, (6) : 1093-1107

Decker, Daniel; Öberg, Christopher; Kleczkowski, Leszek A.

The redox control of photorespiration: from biochemical and physiological aspects to biotechnological considerations

Plant, Cell and Environment, Vol. 40, (4) : 553-569

Keech, Olivier; Gardeström, Per; Kleczkowski, Leszek A.; et al.

Defense Responses in Aspen with Altered Pectin Methylesterase Activity Reveal the Hormonal Inducers of Tyloses

Plant Physiology, AMER SOC PLANT BIOLOGISTS 2017, Vol. 173, (2) : 1409-1419

Lesniewska, Joanna; Ohman, David; Krzeslowska, Magdalena; et al.

Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium

Frontiers in Plant Science, Vol. 6 : 10-

Igamberdiev, Abir U.; Kleczkowski, Leszek A.

Sugar activation for production of nucleotide sugars as aubstrates for glycosyltransferases in plants

Journal of Applied Glycoscience, Tokyo: The Japanese Society of Applied Glycoscience 2015, Vol. 62, (2) : 25-36

Kleczkowski, Leszek A.; Decker, Daniel

Hexokinase 1 is required for glucose-induced repression of bZIP63, At5g22920, and BT2 in Arabidopsis

Frontiers in Plant Science, Vol. 6

Kunz, Sabine; Gardeström, Per; Pesquet, Edouard; et al.

A luminescence-based assay of UDP-sugar producing pyrophosphorylases

Analytical Methods, Vol. 6, (1) : 57-61

Decker, Daniel; Lindberg, Stina; Eriksson, Jonas; et al.

Functional Dissection of Sugar Signals Affecting Gene Expression in Arabidopsis thaliana

PLOS ONE, Vol. 9, (6) : e100312-

Kunz, Sabine; Pesquet, Edouard; Kleczkowski, Leszek A.

Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase

Phytochemistry, Vol. 79 : 39-45

Decker, Daniel; Meng, Meng; Gornicka, Agnieszka; et al.

Temporal matching among diurnal photosynthetic patterns within the crown of the evergreen sclerophyll Olea europaea L

Plant, Cell and Environment, Vol. 34, (5) : 800-810

Granado-Yela, C; García-Verdugo, C; Carrillo, K; et al.

Optimization of CO₂ fixation in photosynthetic cells via thermodynamic buffering.

Biosystems (Amsterdam. Print), Elsevier 2011, Vol. 103, (2) : 224-229

Igamberdiev, Abir U; Kleczkowski, Leszek A

Magnesium and cell energetics in plants under anoxia

Biochemical Journal, Vol. 437, (3) : 373-9

Igamberdiev, Abir U; Kleczkowski, Leszek A

UDP-sugar pyrophosphorylase: a new old mechanism for sugar activation

Plant Physiology, Vol. 156, (1) : 3-10

Kleczkowski, Leszek A; Decker, Daniel; Wilczynska, Malgorzata

A common structural blueprint for plant UDP-sugar-producing pyrophosphorylases.

Biochemical Journal, Colchester: Portland Press 2011, Vol. 439, (3) : 375-379

Kleczkowski, Leszek A; Geisler, Matt; Fitzek, Elisabeth; et al.

A common structural blueprint for plant UDP-sugar-producing pyrophosphorylases

Biochemical Journal, Vol. 439 : 375-379

Kleczkowski, Leszek A.; Geisler, Matt; Fitzek, Elisabeth; et al.

Mechanisms of UDP-glucose synthesis in plants

Critical reviews in plant sciences, Vol. 29, (4) : 191-203

Kleczkowski, Leszek A; Kunz, Sabine; Wilczynska, Malgorzata

Metabolic systems maintain stable non-equilibrium via thermodynamic buffering

Bioessays, Vol. 31, (10) : 1091-1099

Igamberdiev, Abir U; Kleczkowski, Leszek A

Deep shade alters the acclimation response to moderate water streee in Quercus suber L.

Forestry (London), Vol. 82, (3) : 285-298

Jiménez, Maria Dolores; Pardos, Marta; Puértolas, Jaime; et al.

Domain-specific determinants of catalysis/ substrate binding and the oligomerization status of barley UDP-glucose pyrophosphorylase

Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1794 : 1734-1742

Meng, Meng; Fitzek, Elisabeth; Gajowniczek, Agnieszka; et al.

UDP-glucose pyrophosphorylase is not rate limiting, but is essential in arabidopsis

Plant and Cell Physiology, Kyoto: Japanese society of plant physiologists 2009, Vol. 50, (5) : 998-1011

Meng, Meng; Geisler, Matt; Johansson, Henrik; et al.

Molecular and kinetic characterization of two UDP-glucose pyrophosphorylases, products of distinct genes, from Arabidopsis

Biochimica et Biophysica Acta - Proteins and Proteomics, Elsevier 2008, Vol. 1784, (6) : 967-972

Meng, Meng; Wilczynska, Malgorzata; Kleczkowski, Leszek A

A Cytosolic Pathway for the Conversion of Hydroxypyruvate to Glycerate during Photorespiration in Arabidopsis.

The Plant Cell, Vol. 20 : 2848-2859

Timm, Stefan; Nunes-Nesi, Adriano; Pärnik, Tiit; et al.

Differential tissue/organ-dependent expression of two sucrose- and cold-responsive genes for UDP-glucose pyrophosphorylase in Populus.

Gene, Vol. 389, (2) : 186-95

Meng, Meng; Geisler, Matt; Johansson, Henrik; et al.

Phosphate deficiency dependent upregulation of UDP-glucose pyrophosphorylase genes is insensitive to ABA and ethylene status in Arabidopsis leaves

Acta Physiologiae Plantarum, Vol. 28 : 387-393

Ciereszko, Iwona; Kleczkowski, Leszek

A universal algorithm for genome-wide in silicio identification of biologically significant gene promoter putative cis-regulatory-elements; identification of new elements for reactive oxygen species and sucrose signaling in Arabidopsis.

Plant Journal, Vol. 45, (3) : 384-98

Geisler, Matt; Kleczkowski, Leszek; Karpinski, Stanislaw

Poplar carbohydrate-active enzymes. Gene identification and expression analyses.

Plant Physiology, Vol. 140, (3) : 946-62

Geisler-Lee, Jane; Geisler, Matt; Coutinho, Pedro M; et al.

The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show differential sensitivity to short- and long-term exposure to low temperature.

Plant Journal, Vol. 47, (5) : 720-34

Goulas, Estelle; Schubert, Maria; Kieselbach, Thomas; et al.

Equilibration of adenylates in the mitochondrial intermembrane space maintains respiration and regulates cytosolic metabolism.

Journal of Experimental Botany, Vol. 57, (10) : 2133-41

Igamberdiev, Abir U; Kleczkowski, Leszek

Interactive effects of phosphate deficiency, sucrose and light/dark conditions on gene expression of UDP-glucose pyrophosphorylase in Arabidopsis.

Journal of Plant Physiology, Vol. 162, (3) : 343-53

Ciereszko, Iwona; Johansson, Henrik; Kleczkowski, Leszek

Expression of several genes involved in sucrose/starch metabolism as affected by different strategies to induce phosphate deficiency in Arabidopsis

Acta Physiologiae Plantarum, Vol. 27 : 147-155

Ciereszko, Iwona; Kleczkowski, Leszek

Factors affecting oligomerization status of UDP-glucose pyrophosphorylase.

Phytochemistry, Vol. 66, (24) : 2815-21

Kleczkowski, Leszek; Martz, Francoise; Wilczynska, Malgorzata

Toward a blueprint for UDP-glucose pyrophosphorylase structure/function properties: homology-modeling analyses.

Plant Molecular Biology, Vol. 56, (5) : 783-94

Geisler, Matt; Wilczynska, Malgorzata; Karpinski, Stanislaw; et al.

UDP-glucose pyrophosphorylase. An old protein with new tricks.

Plant Physiology, Vol. 134, (3) : 912-8

Kleczkowski, Leszek; Geisler, Matt; Ciereszko, Iwona; et al.

Membrane potential, adenylate levels and Mg2+ are interconnected via adenylate kinase equilibrium in plant cells

Biochimica et Biophysica Acta - Bioenergetics, Vol. 1607, (2-3) : 111-119

Igamberdiev, A U; Kleczkowski, Leszek A

The small subunit ADP-glucose pyrophosphorylase (ApS) promoter mediates okadaic acid-sensitive uidA expression in starch-synthesizing tissues and cells in Arabidopsis

Planta, Vol. 217, (2) : 184-192

Siedlecka, A; Ciereszko, I; Mellerowicz, E; et al.

Effects of phosphate deficiency and sugars on expression of rab18 in Arabidopsis: hexokinase-dependent and okadaic acid-sensitive transduction of the sugar signal

Biochimica et Biophysica Acta, Gene Structure and Expression, Vol. 1579, (1) : 43-49

Ciereszko, I; Kleczkowski, Leszek A

Glucose and mannose regulate the expression of a major sucrose synthase gene in Arabidopsis via hexokinase-dependent mechanisms

Plant physiology and biochemistry (Paris), Vol. 40, (11) : 907-911

Ciereszko, I; Kleczkowski, Leszek A

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