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Staff photo Maria Brattsand

Maria Brattsand

Works at

Affiliation
Senior research engineer at Department of Medical Biosciences Units: Pathology
Location
By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå

KLK4 and prostate cancer

For more than 15 years I have been doing research about Kallikrein-related peptidases (KLK) within the field of dermatology. In 2012, I was recruited by Pernilla Wikström, Department of Medical Biosciences, UmU, to be responsible for cell culture, functional studies and protein characterization in her research group. Thanks to this, I have now had the opportunity to broaden my research area regarding KLK to include cancer.

 

Prostate cancer (PC) is a multifaceted disease with almost 11 000 new cases each year in Sweden.  A big problem is to predict if a tumor will develop into an aggressive form or not, as the treatments available today often result in problems with erection and urine leakage which have impact on the daily life of the patient. The mechanisms behind PC metastasis and castration resistant tumor growth are largely unknown and identification of molecular pathways involved has the potential to improve PC prognosis.

 

Kallikrein related peptidases (KLKs) are a family consisting of 15 different serine proteases where KLK3 is also named PSA and well established as a biomarker for PC. KLK4 has previously been shown to be important for tooth enamel formation. PSA/KLK3 is expressed at very high levels in the prostate, but we have shown that KLK4 is equally highly expressed. In my project, I try to understand the function of KLK4 and to show if it is involved in the development and/or progression of prostate cancer with the ultimate goal to improve diagnostics and treatment of prostate cancer.

Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
The Prostate, John Wiley & Sons 2020, Vol. 80, (2) : 214-224
Bovinder Ylitalo, Erik; Thysell, Elin; Thellenberg-Karlsson, Camilla; et al.
Biomedical Journal of Scientific & Technical Research, Biomedical Research Network 2020, Vol. 28, (2) : 21515-21519
Brattsand, Maria
Marine Drugs, MDPI 2019, Vol. 17, (12)
Chen, Xingchen; Leahy, Darren; Van Haeften, Jessica; et al.
PLOS ONE, Public Library Science 2019, Vol. 14, (1)
Chen, Xingchen; Riley, Blake T.; de Veer, Simon J.; et al.
BestPractice Dermatologi, Ballerup, Danmark: BestPractice ApS 2018, Vol. 9, (25)
Brattsand, Maria
Biological chemistry (Print), Walter de Gruyter 2018, Vol. 399, (9) : 1099-1105
Haddada, Meriem; Draoui, Hend; Deschamps, Lydia; et al.
British Journal of Dermatology, Vol. 176, (1) : 11-12
Brattsand, Maria
Journal of Investigative Dermatology, Vol. 137, (2) : 430-439
de Veer, Simon J.; Furio, Laetitia; Swedberg, Joakim E.; et al.
Molecular Oncology, Vol. 11, (10) : 1330-1347
Delaunay, Tiphaine; Deschamps, Lydia; Haddada, Meriem; et al.
The Prostate, Wiley-Blackwell Publishing Inc. 2017, Vol. 77, (6) : 625-638
Djusberg, Erik; Jernberg, Emma; Thysell, Elin; et al.
PLoS Genetics, PUBLIC LIBRARY SCIENCE 2017, Vol. 13, (1)
Kasparek, Petr; Ileninova, Zuzana; Zbodakova, Olga; et al.
Biological chemistry (Print), Vol. 397, (12) : 1237-1249
de Veer, Simon J.; Swedberg, Joakim E.; Brattsand, Maria; et al.
Biochemical Journal, Vol. 469, (2) : 243-253
de Veer, Simon J.; Swedberg, Joakim E.; Akcan, Muharrem; et al.
Kallikrein-related peptidases: characterization, regulation, and interactions within the protease web, Berlin: Walter de Gruyter 2012 : 329-347
Brattsand, Maria
Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377
Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.
Journal of dermatological science (Amsterdam), Vol. 67, (1) : 73-76
Kaneko, Takanori; Murakami, Masamoto; Kishibe, Mari; et al.
Journal of Investigative Dermatology, Nature Publishing Group 2009, Vol. 129, (7) : 1656-1665
Brattsand, Maria; Stefansson, Kristina; Hubiche, Thomas; et al.
Infection and Immunity, Vol. 77, (3) : 1144-1154
Brännström, Kristoffer; Sellin, Mikael E; Holmfeldt, Per; et al.
Cellular and Molecular Life Sciences (CMLS), Vol. 65, (13) : 2019-2038
Lundwall, Åke; Brattsand, Maria
Journal of Investigative Dermatology, Elsevier 2008, Vol. 128, (1) : 18-25
Stefansson, Kristina; Brattsand, Maria; Roosterman, Dirk; et al.
Molecular biology of the cell, Vol. 18, (9) : 3607-3619
Deraison, Celine; Bonnart, Chrystelle; Lopez, Frederic; et al.
Journal of Investigative Dermatology, Vol. 126, (7) : 1609-21
Hachem, Jean-Pierre; Wagberg, Fredrik; Schmuth, Matthias; et al.
Biological chemistry (Print), Vol. 387, (6) : 761-768
Stefansson, Kristina; Brattsand, Maria; Ny, Annelii; et al.
Journal of Investigative Dermatology, Vol. 124, (1) : 198-203
Brattsand, Maria; Stefansson, Kristina; Lundh, Christine; et al.
British Journal of Dermatology, Vol. 153, (6) : 1200-1203
Egelrud, Torbjörn; Brattsand, Maria; Kreutzmann, P; et al.
Journal of Investigative Dermatology, Vol. 122, (5) : 1235-1244
Caubet, Cécile; Jonca, Nathalie; Brattsand, Maria; et al.
Clinical Cancer Research, American Association for Cancer Research 2003, Vol. 9, (5) : 1710-20
Dong, Ying; Kaushal, Aneel; Brattsand, Maria; et al.
Journal of Investigative Dermatology, Nature Publishing Group 2000, Vol. 114, (1) : 56-63
Ekholm, I Elisabeth; Brattsand, Maria; Egelrud, Torbjörn
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 1999, Vol. 274, (42) : 30033-40
Brattsand, Maria; Egelrud, Torbjörn
Journal of Investigative Dermatology, Nature Publishing Group 1999, Vol. 113, (2) : 152-5
Bäckman, Assar; Strandén, Per; Brattsand, Maria; et al.
Acta Dermato-Venereologica, Society for the Publication of Acta Dermato - Venereologica 1998, Vol. 78, (5) : 343-347
Ekholm, Elisabeth; Sondell, Björn; Strandén, Per; et al.
Microbiology, Society for General Microbiology 1995, Vol. 141, (6) : 1321-1329
Jonsson, Maria; Bergström, Sven
Microbial Pathogenesis, Academic Press 1995, Vol. 18, (2) : 109-14
Jonsson, Maria; Elmros, Teodor; Bergström, Sven
Scandinavian Journal of Infectious Diseases, Informa Healthcare 1992, Vol. 24, (2) : 181-188
Bergström, Sven; Olsén, Björn; Burman, Nils; et al.
Infection and Immunity, American Society for Microbiology 1992, Vol. 60, (5) : 1845-53
Jonsson, Maria; Noppa, L; Barbour, A G; et al.