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Staff photo Michael Druzin

Michael Druzin

Research qualifications: Docent
Educational qualifications: Recognised university teacher

Contact

E-mail
michael.druzin@umu.se
Phone
+46 90 786 54 96

Works as

Affiliation
Associate professor at Department of Medical and Translational Biology Section: Group Michael Druzin
Location
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

We investigate synaptic signaling in hypothalamic circuits using patch-clamp electrophysiology, imaging, and molecular biology to understand brain function in health and disease.

O-GlcNAc transferase couples nutrient availability to synaptic plasticity in paraventricular neurons to regulate satiety
Journal of Biological Chemistry, Elsevier 2026, Vol. 302, (2)
Pérez-del-Pozo, Mario; Bhattacharjee, Manish; Tripathi, Anushree; et al.
Presynaptic chloride-dependent regulation of spontaneous glutamate release in the rat medial preoptic nucleus
Frontiers in Cellular Neuroscience, Frontiers Media S.A. 2026, Vol. 20
Pérez-del-Pozo, Mario; Kuznetsova, Tatiana; Johansson, Staffan; et al.
Shunting effect of synaptic channels located on presynaptic terminal
Advances in neural computation, machine learning, and cognitive research VI: Selected papers from the XXIV International Conference on Neuroinformatics, October 17-21, 2022, Moscow, Russia, Springer Science and Business Media Deutschland GmbH 2023 : 223-230
Kotikova, Marie R.; Druzin, Michael; Chizhov, Anton V.
Heparan sulfates regulate axonal excitability and context generalization through CA2+/Calmodulin-dependent protein kinase II
Cells, MDPI 2023, Vol. 12, (5)
Song, Inseon; Kuznetsova, Tatiana; Baidoe-Ansah, David; et al.
Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes - affecting memory and cognition
Psychoneuroendocrinology, Elsevier 2022, Vol. 141
Das, Roshni; Ragagnin, Gianna; Sjöstedt, Jessica; et al.
Choosing the optimal rat stock as a model for research into pharmacological correction of male sexual dysfunction
Sovremennye Tehnologii v Medicine, Privolzhsky Research Medical University 2021, Vol. 13, (6) : 36-41
Zhuravleva, Z.D.; Titova, N.A.; Mukhina, I.V.; et al.
Effects of Glycine Receptors of the Medial Preoptic Nucleus on Sexual Behavior of Male Wistar Rats
Bulletin of experimental biology and medicine, Springer 2020, Vol. 169, (3) : 299-301
Zhuravleva, Z. D.; Mogutina, M. A.; Mukhina, I. V.; et al.
Contribution of Resting Conductance, GABA(A)-Receptor Mediated Miniature Synaptic Currents and Neurosteroid to Chloride Homeostasis in Central Neurons
eNeuro, Vol. 4, (2)
Yelhekar, Tushar D.; Druzin, Michael; Johansson, Staffan
Preoptic glycine receptors: possible mediators of neuron-glial interaction affecting social behavior in male rats
Glia, John Wiley & Sons 2017, Vol. 65 : E298-E299
Zhuravleva, Z.; Titova, N.; Mukhina, I.; et al.
2-aminoethyl diphenylborinate blocks GABAA-receptor-mediated currents in rat medial preoptic neurons
Opera Medica Et Physiologica, Nizhni Novgorod: Lobachevsky State University of Nizhny Novgorod 2016, Vol. 2, (1) : 63-68
Druzin, Michael; Johansson, Staffan
Commentary: Chloride Regulation: a Dynamic Equilibrium Crucial for Synaptic Inhibition
Frontiers in Cellular Neuroscience, Vol. 10
Johansson, Staffan; Yelhekar, Tushar D.; Druzin, Michael
Mechanism of hypothalamus glycine receptor involvement in regulation of sexual behavior
Acta Physiologica, Vol. 217 : 95-95
Lebedeva, Albina; Zhuravleva, Zoya; Denisov, Pavel; et al.
How to Properly Measure a Current-Voltage Relation? -Interpolation vs. Ramp Methods Applied to Studies of GABA(A) Receptors
Frontiers in Cellular Neuroscience, Vol. 10
Yelhekar, Tushar D.; Druzin, Michael; Karlsson, Urban; et al.
Setting neuronal chloride gradient: a new role for extracellular matrix
Acta Physiologica, Vol. 215 : 45-45
Druzin, Michael
Regulation of neuronal chloride homeostasis: a new role for extracellular matrix
Opera Medica et Physiologica, Lobachevsky State University of Nizhny Novgorod 2015, Vol. 1, (S 1) : 10-10
Druzin, Michael
The effect of glycine microinjections in the medial preoptic area of the hypothalamus on the sexual behavior of male rats
Neurochemical Journal, Vol. 9, (2) : 141-145
Zhuravleva, Z. D.; Lebedeva, A. V.; Volnova, A. B.; et al.
The role of the medial preoptic area glycinergic system in the social types of behavior regulation
Opera Medica et Physiologica, Vol. 1 : 21-22
Zhuravleva, Z.D.; Denisov, P.A.; Urazov, M.D.; et al.
Firing clamp: a novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances.
Frontiers in Cellular Neuroscience, Vol. 8, (86) : 86-
Chizhov, Anton V; Malinina, Evgenia; Druzin, Michael; et al.
Hypoxia on a chip: a novel approach for patch-clamp studies in a microfluidic system with full oxygen control
World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China, Springer Berlin/Heidelberg 2013 : 313-316
Alrifaiy, Ahmed; Bitaraf, Nazanin; Druzin, Michael; et al.
Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons.
PLOS ONE, San Francisco: Public Library of Science 2011, Vol. 6, (5) : e20213-
Druzin, Michael; Malinina, Evgenya; Grimsholm, Ola; et al.
Cl− concentration changes and desensitization of GABAA and glycine receptors
The Journal of General Physiology, Vol. 138, (6) : 609-626
Karlsson, Urban; Druzin, Michael; Johansson, Staffan
Spontaneous ryanodine-receptor-dependent Ca2+-activated K+ currents and hyperpolarizations in rat medial preoptic neurons
Journal of Neurophysiology, Vol. 103, (5) : 2900-2911
Klement, Göran; Druzin, Michael; Haage, David; et al.
Differential control of spontaneous and evoked GABA release by presynaptic L-type Ca(2+) channels in the rat medial preoptic nucleus
Journal of Neurophysiology, Vol. 104, (1) : 200-209
Malinina, Evgenya; Druzin, Michael; Johansson, Staffan
Development of a multifunctional microfluidic system for studies of nerve cell activity during hypoxic and anoxic conditions
International Federation for Medical and Biological Engineering Proceedings; 25 : 176-179
Bitaraf, Nazanin; Ahmed, Ahmed; Druzin, Michael; et al.
Short-term plasticity in excitatory synapses of the rat medial preoptic nucleus.
Brain Research, Vol. 1110, (1) : 128-35
Malinina, Evgenya; Druzin, Michael; Johansson, Staffan
Fast neurotransmission in the rat medial preoptic nucleus.
Brain Research, Vol. 1040, (1-2) : 157-68
Malinina, Evgenya; Druzin, Michael; Johansson, Staffan
Bicuculline free base blocks voltage-activated K+ currents in rat medial preoptic neurons.
Neuropharmacology, Vol. 46, (2) : 285-95
Druzin, Michael; Haage, David; Johansson, Staffan
Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.
Journal of Physiology, Vol. 542, (Pt 1) : 131-46
Druzin, Michael; Haage, David; Malinina, Evgenya; et al.
Allopregnanolone modulates spontaneous GABA release via presynaptic Cl- permeability in rat preoptic nerve terminals
Brain Research, Elsevier 2002, Vol. 958, (2) : 405-413
Haage, David; Druzin, Michael; Johansson, Staffan
O-GlcNAc transferase regulates GABAergic synapse organization and receptor composition
Bhattacharjee, Manish; Han, Linkun; Elenska, Petya; et al.
Differential control of spontaneous and evoked GABA release by presynaptic L-type Ca2+ channels in the rat medial preoptic nucleus
Malinina, Evgenya; Druzin, Michael; Johansson, Staffan
Extracellular Matrix Regulates Neuronal Chloride Concentration via K+-Cl--cotransporter 2
Yelhekar, Tushar; Kuznetsova, Tatiana; Malinina, Evgenya; et al.
View publications in DiVA

Research groups

Head of research
Michael Druzin
Group member
Staffan Johansson

I teach neuroscience and physiology to students in the Medicine, Dentistry, and Cognitive Science programs.

I also serve as course coordinator for four courses at Umeå University.

Medicine Program:

  • Organ Structure and Function (OSoF, 46.5 ECTS)

Bachelor's Program in Cognitive Science:

  • Handling (9 ECTS)
  • NeuroKogVet I (9 ECTS)
  • NeuroKogVet II (9 ECTS)