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Staff photo Mikko Lammi

Mikko Lammi

Investigations on cartilage tissue engineering and endemic osteochondropathy, Kashin-Beck disease

Works at

Affiliation
Professor at Department of Integrative Medical Biology (IMB) Units: Teachers D1-wing, Group Mikko Lammi
Location
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

In this page you will find a short summary of my reseach, but more information is available in my home pages here.

Skeletal diseases, such as osteoarthritis and rheumatoid arthritis, cause extensive health problem among millions of people in the world. The problems include pain, discomfort, and difficulty in having a decent life. Today, there are no good methods for treating the damaged joints. At advanced stage of the disease, the standard treatment is replacement of the joint with a prosthesis. However, during the last 10-15 years, cell-based treatments have been under development as new alternative methods to treat the symptoms of osteoarthritis.

I have investigated how to use tissue engineering technology to produce bone and cartilage in the laboratory. Because the possibilities for isolating cartilage cells for therapy are limited, stem cells have also attracted his interest as alternative cells for cartilage manufacture.

In addition to cartilage tissue technology, I have had a long-term research collaboration with a Chinese group investigating a chronic endemic osteochondropathy, Kashin-Beck disease. This disease affects cartilage and bones already in young age. The cause for it is unknown, however, environment-related factors have been discovered, such as the lack of selenium in soil and contamination of cereals with mycotoxins, to be associated with the disease. Genetic factors are also likely to be involved. My collaborative work in China is aimed at revealing the genetic, proteomic, and metobolomic associations of the disease, and to develop new better research methods to investigate the disease, such patient-specific induced pluripotent stem cell lines.

Cell Death and Disease, Springer Nature 2021, Vol. 12, (6)
Wang, Xi; Ning, Yujie; Zhang, Pan; et al.
Frontiers in Genetics, Frontiers Media S.A. 2021, Vol. 12
Zhang, Yanan; Liu, Huan; Lin, Xialu; et al.
BMC Musculoskeletal Disorders, BioMed Central 2021, Vol. 22, (1)
Zhang, Yanan; Wei, Xiaoli; Cao, Chunxia; et al.
Scientific Reports, Nature Publishing Group 2020, Vol. 10
Lei, Jian; Amhare, Abebe Feyissa; Wang, Liyun; et al.
Histochemistry and Cell Biology, Vol. 153, (3) : 153-164
Lei, Jian; Yan, Siqi; Zhou, Yuan; et al.
Turkish Journal of Medical Sciences, TÜBİTAK (the Scientific and Technological Research Council of Turkey) 2020, Vol. 50, (4) : 1028-1037
Wang, Sen; Gao, Zongqiang; Liu, Huan; et al.
Journal of Cellular Physiology, Wiley-Blackwell 2020, Vol. 235, (5) : 4434-4442
Wang, Xiaoqing; Jin, Zhankui; Chen, Ming; et al.
Clinica Chimica Acta, Elsevier 2020, Vol. 501 : 92-101
Wang, Ying; Wu, Cuiyan; Zhang, Yanan; et al.
Medicine (Baltimore, Md.), Lippincott Williams & Wilkins 2020, Vol. 99, (24)
Zhang, Feng'e; Lammi, Mikko; Tan, Sijia; et al.
International Orthopaedics, Springer 2019, Vol. 43, (2) : 323-331
Jin, Zhan-Kui; Yang, Ying; Xu, Cui-Xiang; et al.
Journal of Applied Toxicology, John Wiley & Sons 2019, Vol. 39, (2) : 343-353
Lin, Xialu; Shao, Wanzhen; Yu, Fangfang; et al.
Experimental Cell Research, Elsevier 2019, Vol. 379, (2) : 140-149
Ning, Yujie; Wang, Xi; Lammi, Mikko; et al.
Cell and Tissue Research, New York: Springer 2019, Vol. 375, (3) : 629-639
Prittinen, Juha; Ylärinne, Janne; Piltti, Juha; et al.
Glycoconjugate Journal, Springer 2019, Vol. 36, (6) : 451-459
Wang, Mengying; Xue, Senhai; Fang, Qian; et al.
Biological Trace Element Research, Springer 2019, Vol. 187, (2) : 367-375
Wang, Sen; Zhao, Guanghui; Shao, Wanzhen; et al.
Genetic Testing and Molecular Biomarkers, Mary Ann Liebert 2019, Vol. 23, (10) : 717-721
Wang, Ying; Wu, Cuiyan; Yang, Yimin; et al.
Genetic Testing and Molecular Biomarkers, Mary Ann Liebert 2019, Vol. 23, (10) : 706-716
Wang, Ying; Wu, Cuiyan; Zhang, Feng; et al.
Toxins, MDPI 2019, Vol. 11, (11) : E667-E667
Zhang, Feng'e; Lammi, Mikko; Shao, Wanzhen; et al.
Clinical Rheumatology, Vol. 38, (9) : 2637-2645
Zhao, Guang-Hui; Yang, Lei; Lammi, Mikko; et al.
Current medical science, Springer 2019, Vol. 39, (2) : 237-242
Zhu, Yan-He; Wang, Xin-Feng; Yang, Guang; et al.
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (9)
Lammi, Mikko; Piltti, Juha; Prittinen, Juha; et al.
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (9)
Lammi, Mikko; Qu, Chengjuan
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Li, Wenrong; Hirvasniemi, Jukka; Guo, Xiong; et al.
Biological Trace Element Research, Springer 2018, Vol. 184, (1) : 16-23
Liu, Huan; Yu, Fangfang; Shao, Wanzhen; et al.
Biological Trace Element Research, Springer 2018, Vol. 183, (2) : 233-244
Ning, Yujie; Wang, Xi; Guo, Xiong; et al.
Journal of Trace Elements in Medicine and Biology, Elsevier 2018, Vol. 50 : 441-460
Ning, Yujie; Wang, Xi; Zhang, Pan; et al.
Journal of Cellular Biochemistry, John Wiley & Sons 2018, Vol. 119, (2) : 2320-2332
Piltti, Juha; Bygdell, Joakim; Qu, Chenjuan; et al.
Biological Trace Element Research, Springer 2018, Vol. 183, (1) : 40-48
Wang, Sen; Lv, Yanyan; Wang, Yingting; et al.
Scientific Reports, London: Nature Publishing Group 2018, Vol. 8
Wang, Sen; Yan, Rui; Wang, Bin; et al.
Matrix Biology, Amsterdam: Elsevier 2017, Vol. 64 : 54-68
Arasu, Uma Thanigai; Kärnä, Riikka; Härkönen, Kai; et al.
Molecular Immunology, Elsevier 2017, Vol. 91 : 195-201
Chang, Yanhai; Wang, Xiao; Sun, Zhengming; et al.
Biomechanics and Modeling in Mechanobiology, Springer Berlin/Heidelberg 2017, Vol. 16, (1) : 297-311
Florea, Cristina; Tanska, Petri; Mononen, Mika; et al.
Endemic disease in China, Beijing: People's Medical Publishing House 2017 : 150-211
Guo, Xiong; Zhang, Feng; Wang, Xi; et al.
Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25, (8) : 1372-1375
Han, Jing; Li, Danyang; Qu, Chengjuan; et al.
PLOS ONE, Vol. 12, (1)
Karhula, Sakari; Finnilä, Mikko; Lammi, Mikko; et al.
Scientific Reports, London: Nature Publishing Group 2017, Vol. 7, (1) : 2231-
Lei, Yang; Guanghui, Zhao; Xi, Wang; et al.
Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25, (5) : 616-624
Liu, Huan; Yang, Lei; Yu, Fang Fang; et al.
Scientific Reports, London: Nature Publishing Group 2017, Vol. 7
Piltti, Juha; Bygdell, Joakim; Fernández-Echevarría, Cecilia; et al.
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Piltti, Juha; Bygdell, Joakim; Fernández-Echevarría, Cecilia; et al.
Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25 : S386-S386
Prittinen, Juha O.; Ylärinne, Janne H.; Piltti, Juha; et al.
Current Regenerative Medicine, Bentham Science 2017, Vol. 7 : 54-63
Qu, Chengjuan; Lammi, Mikko
Journal of Biomedical Optics, SPIE - International Society for Optical Engineering 2017, Vol. 22, (3)
Rieppo, Lassi; Kokkonen, Harri T.; Kulmala, Katariina A. M.; et al.
Molecules, Vol. 22, (5)
Wang, Sen; Fan, Zheng; Zhou, Bing; et al.
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Wu, Cuiyan; Liu, Huan; Zhang, Feng'e; et al.
Toxicon, Amsterdam: Elsevier 2017, Vol. 140 : 38-44
Yang, Lei; Zhang, Jianping; Zhao, Guanghui; et al.
Journal of materials science. Materials in medicine, Springer Publishing Company 2017, Vol. 28, (4)
Ylärinne, Janne; Qu, Chengjuan; Lammi, Mikko
Biomedical and environmental sciences, Vol. 30, (11) : 851-854
Yu, Fang Fang; Lin, Xia Lu; Yang, Lei; et al.
Journal of Trace Elements in Medicine and Biology, Elsevier 2017, Vol. 44 : 218-224
Yu, Fang-Fang; Lin, Xia-Lu; Wang, Xi; et al.

Research groups

Head of research
Mikko Lammi-research group