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Umeå University
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Tor Ny

I do reserach on extracellular matrix degrading proteases and their inhibitors.

Research qualifications: Docent

Contact

E-mail
tor.ny@umu.se
Phone
+46 90 786 65 65, +46 73 620 50 65

Works at

Affiliation
Professor at Department of Medical Biochemistry and Biophysics
Location
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Matrix degrading proteases are involved in a large range of physiological and pathological tissue-remodeling processes, such as wound healing, ovulation and rheumatoid arthritis. We study the functional role of proteases in such processes. We also study the structure and function of serine protease inhibitors (serpins).

Plasminogen receptors and fibrinolysis
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (4) : 1-12
Miles, Lindsey A.; Ny, Lina; Pietrzykowska, Malgorzata; et al.
Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds
Cell Death and Disease, Nature Publishing Group 2020, Vol. 11, (3)
Fallah, Mahsa; Viklund, Emil; Bäckman, Assar; et al.
The Plasminogen Receptor, Plg-R-KT, Regulates Inflammation and Fibrinolysis During Wound Healing
The FASEB Journal, John Wiley & Sons 2020, Vol. 34
Miles, Lindsey; Ny, Lina; Holmberg, Sandra; et al.
The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice
Cell Death and Disease, Springer Nature 2020, Vol. 11, (12)
Ny, Lina; Parmer, Robert J.; Shen, Yue; et al.
Illustrated State-of-the-Art Capsules of the ISTH 2019 Congress in Melbourne, Australia: Plasminogen in wound healing
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, Wiley-Blackwell 2019, Vol. 3, (3) : 431-497
Andrews, Robert K.; Wolberg, Alisa; Lip, Gregory Y. H.; et al.
Disturbed Laminar Blood Flow Causes Impaired Fibrinolysis and Endothelial Fibrin Deposition In Vivo
Thrombosis and Haemostasis, Georg Thieme Verlag KG 2019, Vol. 119, (2) : 223-233
Glise, Lars; Larsson, Pia; Jern, Sverker; et al.
Plasminogen activation is required for the development of radiation-induced dermatitis
Cell Death and Disease, Springer 2018, Vol. 9, (11)
Fallah, Mahsa; Shen, Yue; Brodén, Jessica; et al.
Novel diagnostic ELISA test for discrimination between infections with Yersinia enterocolitica and Yersinia pseudotuberculosis
European Journal of Clinical Microbiology and Infectious Diseases, Springer 2018, Vol. 37, (12) : 2301-2306
Wielkoszynski, Tomasz; Moghaddam, Aliyeh; Backman, Assar; et al.
Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-beta-Slug signaling
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (30) : E4320-E4327
Cheng, Fang; Shen, Yue; Mohanasundaram, Ponnuswamy; et al.
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Cell Host and Microbe, Vol. 19, (1) : 55-66
Moonens, Kristof; Gideonsson, Pär; Subedi, Suresh; et al.
Plasminogen is a critical regulator of cutaneous wound healing
Thrombosis and Haemostasis, Vol. 115, (5) : 1001-1009
Sulniute, Rima; Shen, Yue; Guo, Yong-Zhi; et al.
A reply to the commentary on "Animal models of chronic tympanic membrane perforation: in response to plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice" by Wang AY, Shen Y, Wang JT, Eikelboom RH and Dilley RJ; Clin Translat Med, 2014; 3
Clinical and translational medicine, Springer 2015, Vol. 4, (8)
Hellström, Sten; Shen, Yue; Ny, Tor
A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus
Science, Vol. 346, (6209) : 641-646
Hepburn, Lucy; Prajsnar, Tomasz K; Klapholz, Catherine; et al.
Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice
Journal of Translational Medicine, BioMed Central 2014, Vol. 12
Shen, Yue; Guo, Yongzhi; Wilczynska, Malgorzata; et al.
Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations
PLOS ONE, Public library of science 2012, Vol. 7, (12) : e51303-
Shen, Yue; Guo, Yongzhi; Du, Chun; et al.
Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds
Blood, Washington, USA: American society of hematology 2012, Vol. 119, (24) : 5879-5887
Shen, Yue; Guo, Yongzhi; Mikus, Peter; et al.
Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice
PLOS ONE, Public Library of Science 2011, Vol. 6, (9)
Guo, Yongzhi; Li, Jinan; Hagström, Elin; et al.
Plasmin is essential in preventing periodontitis in mice
American Journal of Pathology, Vol. 179, (2) : 819-828
Sulniute, Rima; Lindh, Tomas; Wilczynska, Malgorzata; et al.
Conformational rearrangements of plasminogen activator inhibitor type 2
Cellular and Molecular Life Sciences (CMLS), Springer 2009, Vol. 66, (10) : 1782-3; author reply 1784
Lobov, S; Wilczynska, Malgorzata; Ranson, M; et al.
Expression patterns of neurotrophins and neurotrophin receptors in articular chondrocytes and inflammatory infiltrates in knee joint arthritis.
Cells, tissues, organs, Vol. 188, (3) : 299-309
Grimsholm, Ola; Guo, Yongzhi; Ny, Tor; et al.
Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis
Arthritis and rheumatism, Vol. 58, (3) : 764-772
Guo, Yongzhi; Li, Jinan; Hagström, Elin; et al.
Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice.
Acta Oto-Laryngologica, Vol. 128, (12) : 1294-1302
Prestwich, Annika Hansson; Li, Jinan; Eriksson, P O; et al.
Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary.
Endocrinology, Vol. 149, (10) : 5070-7
Wahlberg, Patrik; Nylander, Asa; Ahlskog, Nina; et al.
Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and substance P in a murine arthritis model.
Annals of the New York Academy of Sciences, Vol. 1110 : 525-538
Grimsholm, Ola; Guo, Yongzhi; Ny, Tor; et al.
Extentded Förster theory for determining intraprotein distances: 2. An accurate analysis of fluorescence depolarisation experiments
Physical Chemistry, Chemical Physics - PCCP, Royal Society of Chemistry 2007, Vol. 9, (29) : 3914-3922
Isaksson, Mikael; Hägglöf, Peter; Håkansson, Pär; et al.
Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.
Endocrinology, Vol. 148, (3) : 1226-34
Wahlberg, Patrik; Bodén, Ida; Paulsson, Josefin; et al.
Spontaneous development of otitis media in plasminogen-deficient mice
International Journal of Medical Microbiology, Vol. 296, (7) : 501-509
Eriksson, Per-Olof; Li, Jinan; Ny, Tor; et al.
Plasmin/plasminogen is essential for the healing of tympanic membrane perforations.
Thrombosis and Haemostasis, Vol. 96, (4) : 512-519
Li, Jinan; Eriksson, Per-Olof; Hansson, Annika; et al.
Successful ovulation in plasminogen-deficient mice treated with the broad-spectrum matrix metalloproteinase inhibitor galardin.
Developmental Biology, New York: Academic P. 2006, Vol. 295, (2) : 615-622
Liu, Kui; Wahlberg, Patrik; Leonardsson, Göran; et al.
Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.
Arthritis and Rheumatism, Vol. 52, (8) : 2541-2548
Li, Jinan; Guo, Yongzhi; Holmdahl, Rikard; et al.
The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.
American Journal of Pathology, Vol. 166, (3) : 783-792
Li, Jinan; Ny, Annelii; Leonardsson, Göran; et al.
The reactive-center loop of active PAI-1 is folded close to the protein core and can be partially inserted
Journal of Molecular Biology, London: Academic Press 2004, Vol. 335, (3) : 823-832
Hägglöf, Peter; Bergström, Fredrik; Wilczynska, Malgorzata; et al.
Partial donor-donor energy migration (PDDEM): a novel fluorescence method for internal protein distance measurements
Physical Chemistry, Chemical Physics - PCCP, Vol. 6, (11) : 3001-3008
Isaksson, Mikael; Kalinin, Stanislav; Lobov, Sergei; et al.
Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.
Journal of bone and mineral research, Vol. 19, (11) : 1862-72
Kozlenkov, Alexey; Le Du, Marie Helene; Cuniasse, Philippe; et al.
Tissue-type plasminogen activator and its inhibitor plasminogen activator inhibitor type 1 are coordinately expressed during ovulation in the rhesus monkey.
Endocrinology, Vol. 145, (4) : 1767-75
Liu, Yi-Xun; Liu, Kui; Feng, Qiang; et al.
Structural Bases of the Redox-dependent Conformational Switch in the Serpin PAI-2
Journal of Molecular Biology, Vol. 344, (5) : 1359-68
Lobov, Sergei; Wilczynska, Malgorzata; Bergström, Fredrik; et al.
An environmental-sensitive BODIPY®-derivative with bioapplication: spectral and photophysical properties
Journal of Fluorescence, Vol. 13, (5) : 379-84
Isaksson, Mikael; Kalinin, Stanislav; Lobov, Sergei; et al.
Expression pattern and functional studies of matrix degrading proteases and their inhibitors in the mouse corpus luteum
Molecular and Cellular Endocrinology, Vol. 205, (1-2) : 131-140
Liu, Kui; Wahlberg, Patrik; Hägglund, Anna-Carin; et al.
The spontaneous polymerization of plasminogen activator inhibitor type-2 and Z-antitrypsin are due to different molecular aberrations
FEBS Letters, Vol. 537, (1-3) : 11-16
Wilczynska, Malgorzata; Lobov, Sergei; Ny, Tor
A redox-sensitive loop regulates plasminogen activator inhibitor type 2 (PAI-2) polymerization.
EMBO Journal, Vol. 22, (8) : 1753-1761
Wilczynska, Malgorzata; Lobov, Sergei; Ohlsson, Per-Ingvar; et al.
Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biology.
Journal of the American Chemical Society, Vol. 124, (2) : 196-204
Bergström, Fredrik; Mikhalyov, Ilya; Hägglöf, Peter; et al.
Dimers of Dipyrrometheneboron Difluoride (BODIPY) with Light Spectroscopic Applications in Chemistry and Biology
Journal of the American Chemical Society, Vol. 124, (2) : 196-204
Bergström, Fredrik; Mikhalyov, Ilya; Hägglöf, Peter; et al.
Matrix remodeling in the ovary: regulation and functional role of the plasminogen activator and matrix metalloproteinase systems.
Molecular and Cellular Endocrinology, Vol. 187, (1-2) : 29-38
Ny, Tor; Wahlberg, Patrik; Brändström, Ida J M
Dominant expression and distribution of oestrogen receptor beta over oestrogen receptor alpha in the human corpus luteum
Molecular human reproduction, Vol. 7, (2) : 137-145
Hosokawa, K; Ottander, Ulrika; Wahlberg, P; et al.
Stromelysin-3 is induced in mouse ovarian follicles undergoing hormonally controlled apoptosis, but this metalloproteinase is not required for follicular atresia.
Biology of Reproduction, Vol. 64, (2) : 457-63
Hägglund, A C; Basset, P; Ny, Tor
The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites
Structure, with Folding & Design, Vol. 8, (4) : 397-405
Fa, M.; Bergström, F.; Hägglöf, P.; et al.
Conformational studies of plasminogen activator inhibitor type 1 by fluorescence spectroscopy. Analysis of the reactive centre of inhibitory and substrate forms, and of their respective reactive-centre cleaved forms.
European Journal of Biochemistry, Vol. 267, (12) : 3729-34
Fa, M; Bergström, F; Karolin, J; et al.
The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites
Structure, Vol. 8, (4) : 397-405
Fa, Ming; Bergström, Fredrik; Hägglöf, Peter; et al.
Conformational studies of plasminogen activator inhibitor type 1 by fluorescence spectroscopy: Analysis of the reactive centre of inhibitory and substrate forms, and of their respective reactive-centre cleaved forms
European Journal of Biochemistry, Vol. 267, (12) : 3729-34
Fa, Ming; Bergström, Fredrik; Johansson, Lennart B-Å; et al.
A putative stimulatory role of progesterone acting via progesterone receptors in the steroidogenic cells of the human corpus luteum
Biology of Reproduction, Oxford University Press 2000, Vol. 62, (3) : 655-663
Ottander, Ulrika; Hosokawa, Kenichi; Liu, Kui; et al.
View publications in DiVA

Research groups

Head of research
Tor Ny Lab