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Staff photo Ulrika Westerlind

Ulrika Westerlind

Our group is interested in chemical glycobiology.

The projects include 1) synthesis of carbohydrates, glycopeptides, semi-synthetic glycoproteins and glycomimetics; 2) studies of disease relevant protein-carbohydrate interactions; 3) development of glycoproteomic tools and methodology.

Works at

Affiliation
Associate professor at Department of Chemistry
Location
KB.A4, Linnaeus väg 10, (rum: A4.09.01) Umeå universitet, 901 87 Umeå

Our group is interested in chemical glycobiology.

Total synthesis is combined with an enzymatic approach to prepare complex carbohydrates, glycopeptides and semi-synthetic glycoproteins. By using synthetic molecules structural details in protein-carbohydrate interactions are explored, which are relevant in infections, inflammation, cancer and aging. In addition to understand disease mechanisms, an ultimate aim in our projects is to develop glycomimetic inhibitors to block specific protein-carbohydrate interactions for instance to address the current problems with antimicrobial resistance in airway disease infections. 

We further apply synthetic glycopeptides and semi-synthetic glycoproteins to develop glycoproteomic tools for improved enrichment and characterization of glycan structural isomers of glycoproteins and for studies of new PTMs. Small differences in carbohydrate structure has an enormous impact on biological function, for instance in turning on or off an inflammatory pathway and makes the difference beetween being healthy or diseased. More efficient and specific glycoprotein characterization are of enormous importance for new biomarker discovery and for production of safe protein therapeutics (monoclonal antibodies or coagulation factors).  

Glycobiology, Oxford University Press 2021, Vol. 31, (8) : 931-946
Li, Chunxia; Palma, Angelina S.; Zhang, Pengtao; et al.
Organic and biomolecular chemistry, Royal Society of Chemistry 2021, Vol. 19, (11) : 2448-2455
Wu, Xuanjun; McFall-Boegeman, Hunter; Rashidijahanabad, Zahra; et al.
7:e Utvecklingskonferensen för Sveriges ingenjörsutbildningar
Broman, Karolina; Mårell-Olsson, Eva; Johnels, Dan; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2019, Vol. 116, ((15)) : 7278-7287
Malaker, Stacy A.; Pedram, Kayvon; Ferracane, Michael J.; et al.
ACS Chemical Biology, American Chemical Society (ACS) 2019, Vol. 14, (10) : 2176-2184
Wu, Xuanjun; McKay, Craig; Pett, Christian; et al.
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2018, Vol. 57, (30) : 9320-9324
Pett, Christian; Nasir, Waqas; Sihlbom, Carina; et al.
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2018, Vol. 57, (30) : 9268-9273
Shuaishuai, Wang; Qing, Zhang; CongCong, Chen; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2018, Vol. 140, (48) : 16596-16609
Wu, Xuanjun; Yin, Zhaojun; McKay, Craig; et al.
ACS Chemical Biology, American Chemical Society 2018, Vol. 13, (6) : 1668-1676
Yin, Zhaojun; Wu, Xuanjun; Kaczanowska, Katarzyna; et al.
Behren, Sandra; Delgado, Sandra; Arda, Ana; et al.

Research groups

Head of research
Ulrika Westerlind Lab