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Structural Biology

  • Number of credits 7.5 Credits
  • Level Bachelor's level
  • Starting Spring Term 2018

Admitted to the course

Here you will find everything you need to know before the course starts.

About the course

The course comprises two modules:
1. Theory, 5,5 credits. The theoretical part has three sections: A) 3-dimensional structure and function of proteins and nucleic acids at a basic level. B) Structure determination by X-ray crystallography and Nuclear Magnetic Resonance (NMR) spectroscopy, providing both theoretical and practical insights. X-ray crystallography is the most powerful technique currently available for obtaining detailed atomic resolution information of macromolecules. NMRis used for the structural determination of smaller proteins, but the method is also very potent in studies of macromolecules dynamic properties. C) Studies of scientific articles with focus on structural biology. A grant application will be written and orally presented in English.
The theoretical parts of the course address the relationship between protein structure and function. The classification system used for proteins and nucleic acids three-dimensional structures will be studied with the aim to give students a good knowledge of various structural motifs in proteins for example alpha helical domain structures, alpha / beta structures, beta sheet structures. The students will also study the structural background of the behavior of multifunctional enzymes, nucleotide-binding enzymes, DNA-recognizing proteins, receptor-proteins, membrane proteins and 2- and 3 dimensional structures of DNA and RNA. The basic mechanisms behind protein folding, factors that determine protein stability and the structural background of macromolecules dynamics are covered. In the context of protein folding, the concept of misfolded proteins and how these can cause disease will be discussed. The course covers basic principles of macromolecular structure determination by X-ray crystallography and NMR. The goal is that the students can read and understand the technical terms in an article describing a crystal or NMR structure.
2. Laboratory work, 2 credits. In the practical part, computer graphics will be used to visualize and study structural topologies of protein and nucleotide structures obtained from public databases. Structural motifs will be identified and conclusions will be drawn about the protein structure and function. The laboratory experiments include crystallization, analysis of protein crystals, and modeling of protein structures into electron density maps at different resolution cut-offs, in addition to exercises to interpret and arrange NMR spectra.

Application and eligibility

Structural Biology, 7.5 hp

Det finns inga tidigare terminer för kursen Spring Term 2018 Visa tillfällen för efterkommande termin

Starts

Lectures begin on week starting 19 March 2018

Ends

Lectures end during the week of 23 April 2018

Study location

Umeå

Language

English

Type of studies

Daytime, 100%

Required Knowledge

20 ECTS from completed courses in Chemistry, with a minimum of 5 ECTS in Biochemistry, or alternatively, 20 ECTS from a combination of completed courses in Chemistry and Physics and/or Mathematics, with a minimum of 5 ECTS in Biochemistry; 30 ECTS from completed courses in Biology, containing at least 15 ECTS in Cell and Molecular Biology, and at least 5 ECTS in Molecular Genetics.
 

Selection

Academic credits Applicants in some programs at Umeå University have guaranteed admission to this course. The number of places for a single course may therefore be limited.

Application code

UMU-51542

Application

Application deadline was 16 October 2017. Please note: This second application round is intended only for EU/EEA/Swiss citizens. Submit a late application at Universityadmissions.se.

Application and Tuition fees

As a citizen of a country outside the European Union (EU), the European Economic Area (EEA) or Switzerland, you are required to pay application and tuition fees for studies at Umeå University.

Application fee

SEK900

Tuition fee, first instalment

SEK16,875

Total fee

SEK16,875

Contact us

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