Medicinal Chemistry: Design and Combinatorial Chemistry, 15 credits
The course is discontinued from 2021-08-10
Contents
The aim with the course is to give in-depth knowledge within the field of medicinal chemistry. The course focuses in particular on computational methods for design of compounds and parallel synthesis of compound libraries. The course cover the following topics; basic computational chemistry (quantum and molecular mechanics), molecular modelling, docking, QSAR, pharmacophore modelling, library design, parallel synthesis strategies, heterocycle chemistry, scavanger techniques. The course includes a mixture of theory and practice, where the theory is applied through hands-on exercises both in the computational and synthetic parts.
Required Knowledge
Chemometrics (5KE053, 7.5 ECTS), Medicinal Chemistry (5KE059/60, 15 ECTS) and Organic Chemistry (5KE067/5KE068/113, 15 ECTS), or the equivalent. English proficiency equivalent to IELTS Academic Training -minimum score 5.0 with no individual score below 4.5 (tests taken before January 2005 not admissible) or TOEFL - minimum score 500 on paper based test and not below 4.0 on the TWE, Alternatively 173 on computer based test with iBT61 is also required as well as basic entrance requirements for higher studies in Swedish language proficiency if the course is taught in Swedish.
Literature
Valid from: 2009 week 4
Leach Andrew R.
Molecular modelling
: principles and applications
2. ed. :
Harlow :
Prentice Hall :
2001 :
744 s., [8] pl.-bl. (i färg) :
ISBN: 0-582-38210-6 (pbk)
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