Time: 1 June 14:15-15:15
Venue: Lilla Hörsalen, KBC
Online option: Yes
To view the webinar on Zoom, registration needed: https://umu.zoom.us/webinar/register/WN_P-W4VAbpRqeobxBZ311mPA
Pseudo Natural Products – Chemical Evolution of Natural Product Structure
Professor Herbert Waldmann, Max-Planck-Institut für Molekulare Physiologie
Abstract
Natural products have provided inspiration for chemical biology and medicinal chemistry research. Their success raises the fundamental question whether the particular structural and biological properties of natural products can be translated to structurally less demanding compounds, readily accessible by chemical synthesis and yet still endowed with pronounced bioactivity.
The lecture will describe a logic for the simplification of natural product structure by means of “Biology Oriented Synthesis” (BIOS) and its evolution into the “Pseudo Natural Product” (PNP) concept. Pseudo-natural products can be regarded as the human-made equivalent of natural product evolution, i.e. the chemical evolution of natural product structure. Application of natural product inspired compound collections designed and synthesized following these principles in cell-based phenotypic assays and subsequent identification of the cellular target proteins demonstrate that the BIOS and PNPs may enable innovation in both chemical biology and medicinal chemistry research.
Host: Christian Hedberg, Department of Chemistry