NEWS Research at Umeå University shows that in the utricle – which is one of the internal ear’s balance organs in mammals – epithelial cells can be regenerated, resulting in healthy sensory hair cells and surrounding supporting cells.
A recent doctoral dissertation presents research showing that, in the balance organ, sensory receptor cells that had died after being subjected to an antibiotic could be replaced after some time post-trauma. According to the results, the supporting cells undergo a gradual change and develop into new sensory receptor cells without undergoing any additional cell division.
“Balance issues are common, in particular among the older population, and may in many cases be due to damage to the sensory cells within the utricle or other parts of the balance organs,” says Mimmi Werner, doctoral student at the Department of Clinical Sciences and author of the dissertation.
“The supporting cells are to a certain extent able to transform into sensory receptor cells and if this ability could be stimulated, many people would get help in regaining their balance.”
In her research, Mimmi Werner has grown entire utricles in four weeks’ time. By adding an antibiotic poisonous to sensory receptors, the researcher has been able to study the process of cell regeneration and its effect on sensory hair cells and supporting cells.
In conclusion, the result shows that both sensory hair cells and supporting cells survive well during long-term cultivation. When adding a poisonous antibiotic, the majority of sensory cells die. Subsequently, supporting cells very rapidly fill in the space of the dead sensory hair cells. After about two weeks, some of the supporting cells start transforming to new sensory receptor cells (pictured).
On Friday 9 September, Mimmi Werner, Department of Clinical Sciences, Unit for Otorhinolaryngology, defends her dissertation entitled: Hair cell regeneration in vestibular epithelia – a study in an in vitro model. Faculty opponent is Professor Andrew Forge, Centre for Auditory Research, UCL Ear Institute, London, England. Main supervisor is Professor Diana Berggren.
The public defence of the dissertation takes place at 09:00 in Hall D, Node T9, Building 1D, floor 9 at the University Hospital of Umeå (NUS).
Mimmi Werner, Department of Clinical Sciences, Unit for Otorhinolaryngology at Umeå University
Email: mive01@yahoo.se; mimmi.werner@umu.se
Editor: Anna Lawrence